Topical honey application vs. acyclovir for the treatment of recurrent herpes simplex lesions

Medical Science Monitor

Volumn 10, Issue 8, 2004, Pages

  Al Waili, Noori S ^a,b  

^a Medical Research Laboratories   (United Arab Emirates)

^b Dubai Specialized Medical Center   (United Arab Emirates)

Author keywords

Crusting; Genital herpes; HSV; Labial herpes

Indexed keywords

ACICLOVIR;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CREAM; DRUG EFFICACY; DRUG SAFETY; FEMALE; GENITAL HERPES; HEALING; HERPES LABIALIS; HERPES SIMPLEX; HONEY; HUMAN; MALE; PAIN; PRURITUS; RECURRENT DISEASE; REMISSION; SIDE EFFECT;

ACYCLOVIR; ADULT; ANTIVIRAL AGENTS; HERPES GENITALIS; HERPES LABIALIS; HONEY; HUMANS; MIDDLE AGED; SKIN DISEASES, VIRAL;

EID: 4444327372     PISSN: 12341010     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Holy Quran, Surat Al-Nahl, The Bees, Aya 69
2. Oryan A, Zaker R: Effects of topical application of honey on cutaneous wound healing in rabbits. Zentralb Veterinarmed A, 1998; 45: 181-88
3. Al-Waili N, Saloom K: Effects of topical honey on post-operative wound infections due to gram-positive and gram-negative bacteria following cesarean section and hysterectomies. Eur J Med Res, 1999; 4; 126-30
4. Al-Waili N: Therapeutic and prophylactic effects of crude honey on chronic seborrheic dermatitis and dandruff. Eur J Med Res, 2001; 6: 306-8
5. Al-Waili N: Topical application of natural honey, beeswax and olive oil mixture to treat patients with atopic dermatitis or psoriasis: Partially controlled single-blinded study. Complement Ther Med, 2003; 11: 226-34
6. Al-Waili N: An alternative treatment for pityriasis versicolor, tinea crusis, tinea corporis and tinea facici topical application of honey, olive oil and beeswex mixture: an open pilot study. Complement Ther Med, 2004; 12: 45-47
7. Al-Waili N, Jafari S, Ali A: Effects of natural honey on acute bacterial conjunctivitis due to Staphylococcus aureus. FASEB J, 2001; 15: A561
8. Al-Waili N, Jafari S: Effects of honey and cloves extract on bacterial conjunctivitis due to Pseudomonas aeroginosa: compared with antibiotics. FASEB J, 2001; 15: A586
9. Al-Waili N, Al-Alak J, Haq A et al: Effects of honey on gram positive and gram negative bacterial growth in vitro. FASE J, 2001; 15: A586
10. Wahdan A: Causes of antimicrobial activity of honey. Infection, 1998; 26: 26-31
11. Zeina B, Othman O, Al-Assad S: Effect of honey versus thyme on rubella virus survival in vitro. J Altern Complement Med, 1996; 2: 345-48
12. Zeina B, Zohra I, Al-Saasd S: The effects of honey on leishmania parasites: an in vitro study. Trop Doct, 1997; 27: 36-38
13. Whitley J, Kimberlin W, Roizman B: Herpes simplex virus. Clin Infect Dis, 1998; 26: 541-55
14. Annunziato W, Gershon A: Herpes simplex virus infections. Pediatr Rev, 1996; 17: 415-24
15. Clark L, Tatum O, Nober L: Management of genital herpes. Am Fam Physician, 1995; 51: 175-82
16. Goldberg H, Kaufman R, Kurtz O: Long term suppression of recurrent genital herpes with acyclovir: a 5-year benchmark acyclovir study group. Arch Dermatol, 1993; 129: 582-87
17. Whitley J, Gnann W: Acyclovir: a decade later. N Engl J Med, 1992; 327: 782-89
18. Scieux C, Bianchi A: Resistance of herpes simplex viruses to antiviral drugs. Pathol Biol, 1993; 41: 172-77
19. Ernst E, Franey J: Acyclovir- and ganciclovir-induced neurotoxicity. Ann Pharmacother, 1998; 32: 11-113
20. Bourezane Y, Girardin P, Aubin F: Allergic contact dermatitis to Zovirax cream. Allergy, 1996; 51: 755-56
21. Moore O, Smith L, Campbell F, Seers K: Systemic review of the use of honey as a wound dressing. BMC Complementary and Alternative Medicine, 2001; 1: 2-10
22. Dubeski L: Effects of B vitamins injection on bovine herpes virus-1 infections and immunity. J Animal Sci, 1996; 74: 1367-74
23. Hovi T: Topical treatment of recurrent mucocutaneous herpes with ascorbic acid-containing solution. Antiviral Res, 1995; 27: 263-70
24. Fink M: Treatment of herpes simplex by alpha-tocopherol (vitamin-E). Br Dent J, 1980; 148: 246
25. Apsiariyakulm A: Zinc monoglycerolate is effective against oral herpetic sore. Med J Aust, 1990; 152: 54
26. Godfrey H, Godfrey J, Riley D: A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine. Altern Ther Health Med, 2001; 7: 49-56
27. Sagripanti L, Routson B, Bonifacion C: Mechanism of copper-mediated inactivation of herpes simplex virus. Antimicrob Agents Chemother, 1997; 41: 812-17
28. Molan P: The role of honey in the management of wounds. J Wound Care, 1999; 8: 415-18
29. Amoros M, Simsoes M, Girre L, Sauvager F: Synergistic effect of flavones and flavonols against herpes simplex virus type 1 in cell culture. J Nat Prod, 1992; 55: 1732-40
30. Amoros M, Luton E, Boutic J: Comparative of the anti-herpes simplex virus activities of propolis and 3-methyl-but-2-eny caffeate. J Nat Prod, 1994; 57: 644-47
31. Vynograd N, Vynograd I, Sosnowski Z: A comparative multi-center study of the efficacy of propolis, acyclovir and placebo in the treatment of genital herpes. Phytomedicine. 2000; 7: 1-6
32. Al-Waili N: Identification of nitric oxide metabolites in various honeys: Effects of intravenous honey on plasma and urinary nitric oxide metabolites concentrations. J Med Food, 2003; 6: 359-64
33. Al-Waili N: Effects of honey ingestion on nitric oxide in saliva. FASEB J, 2003; 17: A767
34. Pansosian A, Oganessian A, Ambartsumian M: Effects of heavy physical exercise and adaptogens on nitric oxide content in human saliva. Phytomedicine, 1999; 6: 17-26
35. Torre D, Pugliese A, Speranza F: Role of nitric oxide in HIV-1 infection: friend or foe? Lancet Infect Dis, 2002; 2: 273-80
36. Benencia F, Courreges C, Gamba G: Effect of aminoguandine, a nitric oxide synthase inhibitor, on ocular infection with herpes simplex virus in Balb/c mice. Invest Ophthalmol Vis Sci, 2001; 42: 1277-84
37. Al-Waili N, Boni N: Effect of honey on blood and urinary nitric oxide in normal individuals. FASEB J, 2003; 17: A660
38. Wand M, Gilbert C, Lieseganage T: Latanaprost and herpes simplex keratitis. Am J Ophthalmol, 1999; 127: 602-4
39. Baker D, Thomas J: The effect of prostaglandin E2 on the initial immune response to herpes simplex virus infections. Am J Obstet Gynecol, 1985; 151: 586-90
40. Harbour D, Hill T, Blyth W: Prostaglandin enhances intracellular adhesion of vero cell infected with herpes simplex virus. J Gen Virol, 1983; 64: 507-12
41. Bratcher D, Harrison C, Bourne N: Effect of indomethacin on ultraviolet radiation-induced recurrent herpes simplex virus diseases in guinea pigs. J Gen Virol, 1993; 74: 1951-54
42. Santos C, Briones O, Dawson C: Peripheral adrenergic stimulation and indomethacin in experimental ocular shedding of herpes simplex virus. Curr Eye Res, 1987; 6: 111-18
43. Al-Waili N, Thewani A, Al-Azzawi H: The effects of PGA1 on antibody production. The World Conference on Clinical Pharmacology and Therapeutics. 1980, London, 0246
44. Al-Waili N, Boni N: Natural honey lowers plasma prostaglandins concentration in normal individuals. J Med Food, 2003; 6: 129-35
45. Al-Waili N: Effects of honey on the primary and secondary immune responses due to thymus dependent and thymus independent antigens. The Hematol J, 2001; 1(Suppl.1): 161