Mechanism of copper-mediated inactivation of herpes simplex virus

Antimicrobial Agents and Chemotherapy

Volumn 41, Issue 4, 1997, Pages 812-817

  Sagripanti, Jose Luis ^a   Routson, Licia B ^a   Bonifacino, Aylin C ^a   Lytle, C David ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; CUPRIC CHLORIDE; CYSTEINE; HYDROGEN PEROXIDE;

ANTIVIRAL ACTIVITY; ARTICLE; DNA DAMAGE; DRUG EFFECT; DRUG POTENTIATION; HERPES SIMPLEX VIRUS; NONHUMAN; PRIORITY JOURNAL; VIRUS INHIBITION;

EID: 0030933562     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.41.4.812     Document Type: Article

References (37)

1. Aaseth, J., and T. Norseth. 1986. Copper, p. 233-254. In L. Friberg, G. Nordberg, and V. B. Voulk (ed.), Handbood on the toxicology of metals, 2nd ed. Elsevier, New York, N.Y.
2. Arky, R. (ed.). 1995. Physicians' desk reference, 49th ed., p. 827. Medical Economics Data Production Co., Montvale, N.J.
3. Aruoma, O. I., B. Halliwell, E. Gajewski, and M. Dizdaroglu. 1991. Copper- ion-dependent damage to the bases in DNA in the presence of hydrogen peroxide. Biochem. J. 273:601-604.
4. Barry, D. W., and B. Nusinoff. 1985. Viral resistance in clinical practice: summary of five years experience with acyclovir, p. 269-270. In R. Kono and A. Nakajima (ed.), Herpes virus and virus chemotherapy. Exerpta Medica, New York, N.Y.
5. Berglin, E. H., M. B. K. Edlund, G. K. Nyberg, and J. Carlsson. 1982. Potentiation by L-cysteine of the bactericidal effect of hydrogen peroxide in Escherichia coli. J. Bacteriol. 152:81-88.
6. Collins, P., B. A. Larder, N. M. Oliver, et al. 1989. Characterization of a DNA polymerase mutant of herpes simplex virus from a severely immunocompromised patient receiving acyclovir. J. Gen. Virol. 70:375-382.
7. Darby, G. 1994. Acyclovir and beyond. J. Int. Med. Res. 22:33A-42A.
8. Darby, G. 1993. The acyclovir legacy: its contribution to antiviral drug discovery. J. Med. Virol. Suppl. 1:134-138.
9. De Clercq, E. 1993. Antivirals for the treatment of herpesvirus infections. J. Antimicrob. Chemother. 32(Suppl. A):121-132.
10. DeRuiter, A., and R. N. Thin. 1994. Genital herpes. A guide to pharmacological therapy. Drugs 47:297-304.
11. Diem, K. 1965. Documenta Geigy. Scientific tables, 6th Spanish ed. J. R. Geigy, Inc., Basel, Switzerland.
12. Dizdaroglu, M., G. Rao, B. Halliwel, and E. Gajewski. 1991. Damage to the DNA bases in mammalian chromatin by hydrogen peroxide in the presence of ferric and cupric ions. Arch. Biochem. Biophys. 285:317-324.
13. Douglas, G. R., Jr. 1990. Antimicrobal agents, p. 1182-1201. In A. Goodman-Gilman, T. W. Rall, A. S. Nies, and P. Taylor (ed.), The pharmacological basis of therapeutics. Pergamon Press, Elmsford, N.Y.
14. Ellis, M. N., P. M. Keller, J. A. Fyfe, J. L. Martin, J. F. Rooney, S. E. Strauss, S. Nusinoff Lehrman, and D. W. Barry, et al. 1987. Clinical isolates of herpes simplex virus type 2 that induce thymidine kinase with altered substrate specificity. Antimicrob. Agents Chemother. 31:1117-1125.
15. Field, A. K., and K. K. Biron. 1994. "The end of innocence revisited: resistance of herpes viruses to antimicrobial drugs. Clin. Microbiol. Rev. 7:1-13.
16. Field, H. J., G. Darby, and P. Wildy. 1980. Isolation and characterization of acyclovir-resistant mutants of herpes simplex virus. J. Gen. Virol. 49:115-124.
17. Lewis, R. J., and D. V. Sweet. 1983. Registry of toxic effects of chemical substances, 1983 supplement. National Institute for Occupational Safety and Health, Cincinnati, Ohio.
18. Lytle, C. D. 1971. Host-cell reactivation in mammalian cells. I. Survival of ultraviolet-irradiated herpes virus in different cell-lines. Int. J. Radiat. Biol. 19:329-337.
19. McGrath, B. J., and C. L. Newman. 1994. Genital simplex infections in patients with the acquired immunodeficiency syndrome. Pharmacotherapy 14:529-542.
20. Miller, B. M., D. H. M. Groschel, J. H. Richardson, D. Vesley, J. R. Songer, R. D. Housewright, and E. E. Barkley (ed.). 1986. Laboratory safety: principles and practices, p. 56. American Society for Microbiology, Washington, D.C.
21. Nathan, C. F., and R. K. Root. 1977. Hydrogen peroxide release from mouse peritoneal macrophages. J. Exp. Med. 146:1648-1662.
22. O'Brien, J. J., and D. M. Campoli-Richards. 1989. Acyclovir - an updated review of its antiviral activity, pharmacokinetic properties, and therapeutic efficacy. Drugs 37:233-309.
23. Safrin, S. 1992. Treatment of acyclovir-resistant herpes simplex virus in patients with AIDS. J. Acquired Immune Defic. Syndr. 5(Suppl. 1):S29-S32.
24. Sagripanti, J.-L., and L. Cress. Unpublished data.
25. Sagripanti, J.-L., and K. H. Kraemer. 1989. Site-specific oxidative DNA damage at polyguanosine produced by copper plus hydrogen peroxide. J. Biol. Chem. 264:1729-1734.
26. Sagripanti, J.-L., P. L. Goering, and A. Lamanna. 1991. Interaction of copper with DNA and antagonism by other metals. Toxicol. Appl. Pharmacol. 110:477-485.
27. Sagripanti, J.-L. 1992. Metal based formulations with high microbicidal activity. Appl. Environ. Microbiol. 58:3157-3162.
28. Sagripanti, J.-L., L. B. Routson, and C. D. Lytle. 1993. Virus inactivation by copper or iron ions alone and in the presence of peroxide. Appl. Environ. Microbiol. 59:4374-4376.
29. Sagripanti, J.-L., and M. M. Lightfoote. 1996. Cupric and ferric ions inactivate HIV. AIDS Res. Hum. Retroviruses 12:333-336.
30. Samuni, A., J. Aronovitch, D. Godinger, M. Chevion, and G. Czapski. 1983. On the cytotoxicity of vitamin C and metal ions. A specific Fenton mechanism. Eur. J. Biochem. 137:119-124.
31. Sasadeusz, J. J., and S. L. Sacks. 1993. Systemic antivirals in herpesvirus infections. Dermatol. Ther. 11:171-185.
32. Schubert, J., and J. W. Wilmer. 1991. Does hydrogen peroxide exist "free" in biological systems? Free Radical Biol. Med. 11:545-555.
33. Toyokuni, S., and J.-L. Sagripanti. 1992. Iron-mediated DNA damage: sensitive detection of DNA strand breakage catalyzed by iron. J. Inorg. Biochem. 47:241-248.
34. Toyokuni, S., and J.-L. Sagripanti. 1993. DNA single and double strand breaks produced by ferric NTA in relationship to renal tubular carcinogenesis. Carcinogenesis 14:223-227.
35. Toyokuni, S., and J.-L. Sagripanti. 1994. Increased 8-hydroxyguanosine in kidney and liver of rats continuously exposed to copper. Toxicol. Appl. Pharmacol. 126:91-97.
36. Toyokuni, S., and J.-L. Sagripanti. 1996. Association between 8-hydroxy-2′- deoxyguanosine formation and DNA strand breaks mediated by copper and iron. Free Radical Biol. Med. 20:859-864.
37. World Health Organization. 1989. Guidelines on sterilization and disinfection methods against HIV. WHO AIDS Series 2, 2nd ed. World Health Organization, Geneva, Switzerland.