Cationic anti-microbial peptides: From innate immunity study to drug development;Peptides antimicrobiens cationiques: De l'étude de l'immunité innée à la production de médicaments

Revue de Medecine Interne

Volumn 25, Issue 9, 2004, Pages 629-635

  Andres E ^a,c   Dimarcq, J L ^a,b  

^a INSTITUT DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b EntoMed SA   (France)

^c UNIVERSITY HOSPITAL OF STRASBOURG   (France)

Author keywords

Anti microbial peptides; Drugs; Immunit inn e; Infections; Innate immunity; M dicaments; Peptides antimicrobiens

Indexed keywords

ANTIMICROBIAL CATIONIC PEPTIDE; HELIOMYCIN; HISTATIN; INDOLICIDIN; MAGAININ 1; PROTEGRIN; THANATINE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; BACTERIUM; FUNGUS; HOST RESISTANCE; IMMUNE RESPONSE; PATHOGENESIS; REVIEW; VIRUS;

EID: 4444310884     PISSN: 02488663     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.revmed.2004.02.025     Document Type: Short Survey

References (44)

1. Breithaupt H. The new antibiotics. Nature. 17:1999;1165-1169
2. Gura T. Innate immunity: ancient system gets new respect. Science. 291:2001;2068-2071
3. Hancock R.E., Patrzykat A. Clinical development of cationic antimicrobial peptides: from natural to novel antibiotics. Curr Drug Targets Infect Disord. 2:2002;79-83
4. Hoffmann J.A., Kafatos F.C., Janeway C.A., Ezekowitz R.A. Phylogenetic perspectives in innate immunity. Science. 284:1999;1313-1318
5. Lehrer R.I., Ganz T. Anti-microbial peptides in mammalian and insect host defence. Curr Opin Immunol. 11:1999;23-27
6. Ganz T., Lehrer R.I. Anti-microbial peptides of vertebrates. Curr Opin Immunol. 10:1998;41-44
7. Hancock R.E.W. Host defense peptides. Drugs. 57:1999;469-473
8. Hancock R.E. Cationic peptides: effectors in innate immunity and novel antimicrobials. Lancet Infect Dis. 1:2001;156-164
9. Hiemstra P.S. Epithelial antimicrobial peptides and proteins: their role in host defence and inflammation. Paediatr Respir Rev. 2:2001;306-310
10. Giacometti A., Cirioni O., Ghiselli R., Mocchegiani F., D'Amato G., Circo R., et al. Cathelicidin peptide sheep myeloid antimicrobial peptide-29 prevents endotoxin-induced mortality in rat models of septic shock. Am J Respir Crit Care Med. 169:2004;187-194
11. Ong P.Y., Ohtake T., Brandt C., Strickland I., Boguniewicz M., Ganz T., et al. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med. 347:2002;1151-1160
12. Putsep K., Carlsson G., Boman H.G., Andersson M. Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study. Lancet. 360:2002;1144-1149
13. Hoffmann J.A. The immune response of Drosophila. Nature. 426:2003;33-38
14. Hetru C., Troxler L., Hoffmann J.A. Drosophila melanogaster antimicrobial defense. J Infect Dis. 187:(Suppl 2):2003;S327-34
15. Dimarcq J.L., Bulet P., Hetru C., Hoffmann J. Cysteine-rich anti-microbial peptides in invertebrates. Biopolymers. 47:1998;465-477
16. Boman H.G. Antibacterial peptides: basic facts and emerging concepts. J Intern Med. 254:2003;197-215
17. Boman H.G. Gene-encoded peptide antibiotics and the concept of innate immunity: an update review. Scand J Immunol. 48:1998;15-25
18. Berkowitz B.A., Bevins C.L., Zasloff M.A. Magainins: a new family of membrane-active host defense peptides. Biochem Pharmacol. 39:1990;625-629
19. Lehrer R.I., Ganz T. Endogenous vertebrate antibiotics. Defensins, protegrins, and other cysteine-rich anti-microbial peptides. Ann NY Acad Sci. 797:1996;228-239
20. Garcia-Olmedo F., Molina A., Alamillo J.M., Rodriguez-Palenzuela P. Plant defense peptides. Biopolymers. 47:1998;479-491
21. van Abel R.J., Tang Y.Q., Rao V.S., Dobbs C.H., Tran D., Barany G., et al. Synthesis and characterization of indolicidin, a tryptophan-rich anti-microbial peptide from bovine neutrophils. Int J Pept Protein Res. 45:1995;401-409
22. Bulet P., Hetru C., Dimarcq J.L., Hoffmann D. Anti-microbial peptides in insects; structure and function. Dev Comp Immunol. 23:1999;329-344
23. Hancock R.E.W., Rozek A. Role of membrane in the activities of antimicrobial cationic peptides. FEMS Microbiol Lett. 206:2002;143-149
24. Oren Z., Shai Y. Mode of action of linear amphipathic alpha-helical anti-microbial peptides. Biopolymers. 47:1998;451-463
25. Hwang P.M., Vogel H.J. Structure-function relationships of anti-microbial peptides. Biochem Cell Biol. 76:1998;235-246
26. Cociancich S., Ghazi A., Hetru C., Hoffmann J.A., Letellier L. Insect defensin, an inducible antibacterial peptide, forms voltage-dependent channels in Micrococcus luteus. J Biol Chem. 268:1993;19239-19245
27. Ganz T., Lehrer R.I. Antibiotic peptides from higher eukaryotes: biology and applications. Mol Med Today. 5:1999;292-297
28. Otvos L., Rogers M.E., Consolvo P.J., Condie B.A., Lovas S., Bulet P., et al. Interaction between heat shock proteins and anti-microbial peptides. Biochemistry. 39:2000;14150-14159
29. Thevissen K., Cammue B.P., Lemaire K., Winderickx J., Dickson R.C., Lester R.L., et al. A gene encoding a sphingolipid biosynthesis enzyme determines the sensitivity of Saccharomyces cerevisiae to an antifungal plant defensin from dahlia (Dahlia merckii). Proc Natl Acad Sci USA. 97:2000;9531-9536
30. Scott M.G., Rosenberger C.M., Gold M.R., Finlay B.B., Hancock R.E. An alpha-helical cationic anti-microbial peptide selectively modulates macrophage responses to lipopolysaccharide and directly alters macrophage gene expression. J Immunol. 165:2000;3358-3365
31. Scott M.G., Hancock R.E. Cationic anti-microbial peptides and their multifunctional role in the immune system. Crit Rev Immunol. 20:2000;407-431
32. Hancock R.E.W. Cationic anti-microbial peptides: toward clinical application. Expert Opin Investig Drugs. 9:2000;1723-1729
33. Andrès E., Dimarcq J.L. Les peptides antimicrobiens cationiques et leurs applications potentielles. Antibiotiques. 3:2001;201-205
34. Andrès E., Dimarcq J.L. Cationic antimicrobial peptides: update of clinical development. J Intern Med. 255:2003;519-520
35. Jacob L., Zasloff M. Potential therapeutic applications of magainins and other anti-microbial agents of animal origin. Ciba Found Symp. 186:1994;197-216. discussion 216-23
36. Lamb H.M., Wiseman L.R. Pexiganan acetate. Drugs. 56:1998;1047-1052
37. Loury D., Embree J.R., Steinberg D.A., Sonis S.T., Fiddes J.C. Effect of local application of the anti-microbial peptide IBL-367 on the incidence and severity of oral mucositis in hamsters. Oral Surg, Oral Med, Oral Path, Oral Radiol and Endodontics. 87:1999;544-551
38. Bellm L., Lehrer R.I., Ganz T. Protegrins: new antibiotics of mammalian origin. Expert Opin Investig Drugs. 9:2000;1731-1742
39. Paquette D.W., Simpson D.M., Friden P., Braman V., Williams R.C. Safety and clinical effects of topical histatin gels in human with experimental gingivitis. J Clin Periondotal. 29:2002;1051-1058
40. Giroir B.P., Quint P.A., Barton P., Kirsch E.A., Kitchen L., Goldstein B., et al. Preliminary evaluation of recombinant amino-terminal fragment of human bactericidal/permeability increasing protein in children with severe meningococcal sepsis. Lancet. 350:1997;1439-1443
41. Demetriades D., Smith J.S., Jacobson L.E., Moncure M., Minei J., Nelson B.J., et al. Bactericidal/permeability increasing protein (rBPI-21) in patients with hemorrhage due to trauma: results of a multicenter phase II clinical trial. Trauma. 46:1999;667-676
42. Hoffmann J.A. The immune system of Drosophila. Nature. 426:2003;33-38
43. Lemaitre B., Reichhart J.M., Hoffmann J.A. Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms. Proc Natl Acad Sci USA. 94:1997;14614-14619
44. Pages J.M., Dimarcq J.L., Quenin S., Hetru C. Thanatin activity on multidrug resistant clinical isolates of Enterobacter aerogenes and Klebsiella pneumoniae. Int J Antimicrob Agents. 22:2003;265-269