Leishmania major LmACR2 is a pentavalent antimony reductase that confers sensitivity to the drug Pentostam

Journal of Biological Chemistry

Volumn 279, Issue 36, 2004, Pages 37445-37451

  Zhou, Yao ^a   Messier, Nadine ^b   Ouellette, Marc ^b   Rosen, Barry P ^a   Mukhopadhyay, Rita ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PHENOTYPE; REDUCTASE;

ANTIMONY; DISEASE CONTROL; DRUG PRODUCTS; ENZYMES; ESCHERICHIA COLI;

BIOCHEMISTRY;

ANTIMONY DERIVATIVE; ANTIMONY REDUCTASE; FUNGAL ENZYME; MEGLUMINE ANTIMONATE; ORGANOARSENIC DERIVATIVE; OXIDOREDUCTASE; PROTEIN LMACR2; PROTEIN SCACR2P; PROTOZOAL PROTEIN; STIBOGLUCONATE SODIUM; UNCLASSIFIED DRUG;

AMASTIGOTE; ARTICLE; CROSS RESISTANCE; DRUG ACTIVITY; DRUG PROTEIN BINDING; DRUG SENSITIVITY; GENETIC TRANSFECTION; LEISHMANIA MAJOR; LEISHMANIASIS; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; TRYPANOSOMIASIS;

AMINO ACID SEQUENCE; ANIMALS; ANTIMONY SODIUM GLUCONATE; ANTIPROTOZOAL AGENTS; CLONING, MOLECULAR; LEISHMANIA MAJOR; MOLECULAR SEQUENCE DATA; OXIDOREDUCTASES; SEQUENCE HOMOLOGY, AMINO ACID;

ESCHERICHIA COLI; LEISHMANIA INFANTUM; LEISHMANIA MAJOR; PROTOZOA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 4444301522     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M404383200     Document Type: Article

References (35)

1. Lockwood, D. (2004) Nat. Med. 10, 110
2. Grogl, M., Thomason, T. N., and Franke, E. D. (1992) Am. J. Trop. Med. Hyg. 47, 117-126
3. Sundar, S., More, D. K., Singh, M. K., Singh, V. P., Sharma, S., Makharia, A., Kumar, P. C., and Murray, H. W. (2000) Clin. Infect. Dis. 31, 1104-1107
4. Sereno, D., Cavaleyra, M., Zemzoumi, K., Maquaire, S., Ouaissi, A., and Lemesre, J. L. (1998) Antimicrob. Agents Chemother. 42, 3097-3102
5. Ephros, M., Bitnun, A., Shaked, P., Waldman, E., and Zilberstein, D. (1999) Antimicrob. Agents Chemother. 43, 278-282
6. Shaked-Mishan, P., Ulrich, N., Ephros, M., and Zilberstein, D. (2001) J. Biol. Chem. 276, 3971-3976
7. Liu, Z., Carbrey, J. M., Agre, P., and Rosen, B. P. (2004) Biochem. Biophys. Res. Commun. 316, 1178-1185
8. Liu, Z., Shen, J., Carbrey, J. M., Mukhopadhyay, R., Agre, P., and Rosen, B. P. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 6053-6058
9. Meng, Y. L., Liu, Z., and Rosen, B. P. (2004) J. Biol. Chem. 279, 18334-18341
10. Ghosh, M., Shen, J., and Rosen, B. P. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 5001-5006
11. Dey, S., Ouellette, M., Lightbody, J., Papadopoulou, B., and Rosen, B. P. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 2192-2197
12. Dey, S., Dou, D., and Rosen, B. P. (1994) J. Biol. Chem. 269, 25442-25446
13. Mukhopadhyay, R., and Rosen, B. P. (2002) Environ. Health Perspect. 110, Suppl. 5, 745-748
14. Denton, H., McGregor, J. C., and Coombs, G. H. (2004) Biochem. J. 381, 405-412
15. Mukhopadhyay, R., and Rosen, B. P. (1998) FEMS Microbiol. Lett. 168, 127-136
16. Mukhopadhyay, R., and Rosen, B. P. (2001) J. Biol. Chem. 276, 34738-34742
17. Mukhopadhyay, R., Shi, J., and Rosen, B. P. (2000) J. Biol. Chem. 275, 21149-21157
18. Mukhopadhyay, R., Zhou, Y., and Rosen, B. P. (2003) J. Biol. Chem. 278, 24476-24480
19. Fauman, E. B., and Saper, M. A. (1996) Trends Biochem. Sci. 21, 413-417
20. Hofmann, K., Bucher, P., and Kajava, A. V. (1998) J. Mol. Biol. 282, 195-208
21. Oden, K. L., Gladysheva, T. B., and Rosen, B. P. (1994) Mol. Microbiol. 12, 301-306
22. Sereno, D., Holzmuller, P., Mangot, I., Cuny, G., Ouaissi, A., and Lemesre, J. L. (2001) Antimicrob. Agents Chemother. 45, 2064-2069
23. White, T. C., Fase-Fowler, F., van Luenen, H., Calafat, J., and Borst, P. (1988) J. Biol. Chem. 263, 16977-16983
24. Roy, G., Dumas, C., Sereno, D., Wu, Y., Singh, A. K., Tremblay, M. J., Ouellette, M., Olivier, M., and Papadopoulou, B. (2000) Mol. Biochem. Parasitol. 110, 195-206
25. Shi, J., Vlamis-Gardikas, A., Aslund, F., Holmgren, A., and Rosen, B. P. (1999) J. Biol. Chem. 274, 36039-36042
26. Gill, S. C., and von Hippel, P. H. (1989) Anal. Biochem. 182, 319-326
27. Miekeley, N., Mortari, S. R., and Schubach, A. O. (2002) Anal. Bioanal. Chem. 372, 495-502
28. Gladysheva, T. B., Oden, K. L., and Rosen, B. P. (1994) Biochemistry 33, 7288-7293
29. Croft, S. L., and Coombs, G. H. (2003) Trends Parasitol. 19, 502-508
30. Gourbal, B., Sonuc, N., Bhattacharjee, R., Legare, D., Sundar, S., Ouellette, M., Rosen, B. P., and Mukhopadhyay, R. (2004) J. Biol. Chem. 279, 31010-31017
31. Fairlamb, A. H., and Cerami, A. (1992) Annu. Rev. Microbiol. 46, 695-729
32. Nogoceke, E., Gommel, D. U., Kiess, M., Kalisz, H. M., and Flohe, L. (1997) Biol. Chem. Hoppe-Seyler 378, 827-836
33. Dormeyer, M., Reckenfelderbauraer, N., Ludemann, H., and Krauth-Siegel, R. L. (2001) J. Biol. Chem. 276, 10602-10606
34. Reckenfelderbaumer, N., and Krauth-Siegel, R. L. (2002) J. Biol. Chem. 277, 17548-17555
35. Gommel, D. U., Nogoceke, E., Morr, M., Kiess, M., Kalisz, H. M., and Flohe, L. (1997) Eur. J. Biochem. 248, 913-918