The effects of tibolone and oestrogen-based HT on breast cell proliferation and mammographic density

Maturitas

Volumn 49, Issue 1, 2004, Pages

  Von Schoultz, B ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Breast cell proliferation; Effects; Mammographic density; Oestrogen based HT; Tibolone

Indexed keywords

CONJUGATED ESTROGEN; ESTRADIOL; ESTRIOL; MEDROXYPROGESTERONE ACETATE; NOMEGESTROL ACETATE; ORAL CONTRACEPTIVE AGENT; RALOXIFENE; TAMOXIFEN; TIBOLONE;

BREAST; BREAST CARCINOMA; BREAST CELL; CANCER RISK; CELL PROLIFERATION; CLINICAL TRIAL; CONFERENCE PAPER; DRUG MECHANISM; DRUG SELECTIVITY; HORMONE SUBSTITUTION; HUMAN; IN VITRO STUDY; MAMMOGRAPHY; MENOPAUSAL SYNDROME; NONHUMAN; POSTMENOPAUSE OSTEOPOROSIS; SIDE EFFECT;

BREAST; CELL PROLIFERATION; ESTROGENS; FEMALE; HORMONE REPLACEMENT THERAPY; HUMANS; MAMMOGRAPHY; NORPREGNENES; SELECTIVE ESTROGEN RECEPTOR MODULATORS;

EID: 4444298856     PISSN: 03785122     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.maturitas.2004.06.011     Document Type: Conference Paper

References (29)

1. Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women. JAMA 2002;288:321-33.
2. Santen R.J., Pinkerton J., McCartney C., Petroni G.R. Risk of breast cancer with progestins in combination with estrogens as hormone replacement therapy. J. Clin. Endocrinol. Metab. 86:2001;16-23
3. Lehman C.D., White E., Peacock S., Drucker M.J., Urban N. Effect of age and breast density on screening mammograms with false-positive findings. AJR Am. J. Roentgenol. 173:1999;1651-1655
4. Söderqvist G., Isaksson E., von Schoultz B., Carlström K., Tani E., Skoog L. Proliferation of breast epithelial cells in healthy women during the menstrual cycle. Am. J. Obstet. Gynecol. 176:1997;123-128
5. Söderqvist G., von Schoultz B., Tani E., Skoog L. Estrogen and progesterone receptor content in breast epithelial cells from healthy women during the menstrual cycle. Am J. Obstet. Gynecol. 168:1993;874-879
6. Menard S., Casalini P., Agresti R., Pilotti S., Balsari A. Proliferation of breast carcinoma during menstrual phases. Lancet. 352:1998;148-149
7. Isaksson E., von Schoultz E., Odlind V., et al. Effects of oral contraceptives on breast epithelial proliferation. Breast Cancer Res. Treat. 65:2001;163-169
8. Cline J.M., Söderqvist G., von Schoultz E., Skoog L., von Schoultz B. Effects of conjugated estrogens, medroxyprogesterone acetate and tamoxifen on the mammary glands of macaques. Breast Cancer Res. Treat. 48:1998;221-229
9. Hofseth L.J., Raafat A.M., Osuch J.R., Pathak D.R., Slomski C.A., Haslam S.Z. Hormone replacement therapy with estrogen or estrogen plus medroxyprogesterone acetate is associated with increased epithelial proliferation in the normal postmenopausal breast. J. Clin. Endocrinol. Metab. 84:1999;4559-4565
10. Kloosterboer H.J. Tibolone: a steroid with a tissue-selective mode of action. J. Steroid Biochem. Mol. Biol. 76:2001;231-238
11. Palacios S. Tibolone: what does tissue specific activity mean? Maturitas. 37:2001;159-165
12. Kloosterboer HJ. New mechanisms of action for tibolone in breast cancer. In: Neves-e-Castro M, Wren BG, editors. Menopause hormones and cancer. New York: Parthenon; 2003. p. 37-47.
13. Chetrite G., Kloosterboer H.J., Pasqualini J.R. Effect of tibolone (Org OD14) and its metabolites on estrone sulphatase activity in MCF-7 and T-47D mammary cancer cells. Anticancer Res. 17:1997;135-140
14. Kloosterboer H.J. Tibolone: a steroid with a tissue-selective mode of action. J. Steroid Biochem. Mol. Biol. 76:2001;231-238
15. Gooyer de M.E., Oppers-Tiemissen H.M., Leysen D., Verheul H.A.M., Kloosterboer H.J. Tibolone is not converted by human aromatase to 7α-methyl-17α-ethynylestradiol (7α-MEE): analyses with sensitive bioassays for estrogens and androgens and with LC-MS/MS. Steroids. 68:2003;235-243
16. Gompel A., Kandouz M., Siromachkova M., et al. The effect of tibolone on proliferation. Gynecol. Endocrinol. 11(Suppl. 1):1997;77-79
17. Gompel A., Chaouat M., Jacob D., Perrot J.-Y., Kloosterboer H.J., Rostene W. In vitro studies of tibolone in breast cells. Fertil. Steril. 78:2002;351-359
18. Sendaǧ F., Terek M.C., Öz_ener S., Öztekin K. Mammographic density changes in postmenopausal women using tibolone therapy. Int. J. Gynecol. Obstet. 74:2001;63-64
19. Erel C.T., Elter K., Akman C., et al. Mammographic changes in women receiving tibolone therapy. Fertil. Steril. 69:1998;870-875
20. Kutlu T., Ficicioglu C. The mammographic breast density changes after one year of tibolone use. Climacteric. 5(Suppl. 1):2002;138-139
21. Valdivia I., Ortega D. Mammographic density in postmenopausal women treated with tibolone, estriol or conventional hormone replacement therapy. Clin. Drug Invest. 20:2000;101-107
22. Colacurci N., Fornaro F., de Franciscis P., Palermo M., del Vecchio E. Effects of different types of hormone replacement therapy on mammographic density. Maturitas. 40:2001;159-164
23. Christodoulakos G.E., Lambrinoudaki I.V., Vourtsi A.D., Panoulis K.P.C., Kelekis D.A., Creatsas G.C. Mammographic changes associated with raloxifene and tibolone therapy in postmenopausal women: a prospective study. Menopause. 9:2002;110-116
24. Valdivia I, Campodónico I, Tapia A, Capetillo M, Espinoza A, Lavín P. Effect of tibolone and continuous combined hormone replacement therapy on mammographic breast density and breast histochemical markers in postmenopausal women. Fertil Steril, submitted for publication.
25. Ozdemir A., Konus O., Nas T., Erbas G., Cosar S., Iskik S. Mammographic and ultrasonic study of changes in the breast related to HRT. Int. J. Gynecol. Obstet. 67:1999;23-32
26. Şendaǧ F., Cosan Terek M., Ozsener S., et al. Mammographic density changes during different postmenopausal hormone replacement therapies. Fertil. Steril. 76:2001;445-450
27. Erel C.T., Esen G., Seyisoglu H., et al. Mammographic density increase in women receiving different hormone replacement regimens. Maturitas. 40:2001;151-157
28. Lundström E., Christow A., Svane G., et al. Effects of tibolone and a continuous combined HRT regimen on mammographic breast density. Am. J. Obstet. Gynecol. 186:2002;717-722
29. Conner P., Christow A., Kersemaekers W., et al. A comparative study on breast cell proliferation during HRT effects of tibolone and continuous combined estrogen progestogen treatment. Climacteric. 7:2004;50-58