Increased neurogenesis in a rat ketamine model of schizophrenia

Biological Psychiatry

Volumn 56, Issue 5, 2004, Pages 317-322

  Keilhoff, Gerburg ^a   Bernstein, Hans Gert ^a   Becker, Axel ^a   Grecksch, Gisela ^a   Wolf, Gerald ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

BrdU; hippocampus; immunocytochemistry; ketamine; neurogenesis; schizophrenia

Indexed keywords

BROXURIDINE; KETAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NITRIC OXIDE; PARVALBUMIN; PROTEIN C FOS; PROTEIN C JUN; TRANSCRIPTION FACTOR AP 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BIOLOGICAL MODEL; BRAIN DEPTH STIMULATION; BRAIN REGION; CELL LOSS; CONTROLLED STUDY; HIPPOCAMPUS; IMMUNOCYTOCHEMISTRY; MALE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SCHIZOPHRENIA; SEROTONINERGIC NERVE CELL;

ANIMALS; ANTIGENS; BROMODEOXYURIDINE; CELL DIFFERENTIATION; CELL DIVISION; DISEASE MODELS, ANIMAL; EXCITATORY AMINO ACID ANTAGONISTS; GLIAL FIBRILLARY ACIDIC PROTEIN; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; INTERMEDIATE FILAMENT PROTEINS; KETAMINE; MALE; MICROTUBULE-ASSOCIATED PROTEINS; NERVE TISSUE PROTEINS; NEURONS; PARVALBUMINS; PHOSPHOPYRUVATE HYDRATASE; PROTEOGLYCANS; RATS; RATS, SPRAGUE-DAWLEY; SCHIZOPHRENIA;

EID: 4444267907     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2004.06.010     Document Type: Article

References (52)

1. P. Arlotta, S.S. Magavi, J.D. Macklis Induction of adult neurogenesis Molecular manipulation of neural precursors in situ Ann N Y Acad Sci 991 2003 229 236
2. S.E. Arnold, L.Y. Han, P.J. Moberg, B.I. Turetsky, R.E. Gur, J.Q Trojanowski Dysregulation of olfactory receptor neuron lineage in schizophrenia Arch Gen Psychiatry 58 2001 829 835
3. A. Arvidsson, T. Collin, D. Kirik, Z. Kokaia, O. Linvall Neuronal replacement from endogenous precursors in the adult brain after stroke Nat Med 8 2002 963 970
4. waf1/cip1 in the regulation of vascular smooth muscle cell proliferation by nitric oxide Proc Natl Acad Sci U S A 98 2001 12802 12807
5. A. Becker, B. Peters, H. Schroeder, T. Mann, G. Huether, G. Grecksch Ketamine-induced changes in rat behaviour A possible animal model of schizophrenia Prog Neuropsychopharmacol Biol Psychiatry 27 2003 687 700
6. H.-G. Bernstein, A. Becker, G. Keilhoff, C. Spilker, A. Gorczyca, K.-H. Braunewell Brain region-specific changes in the expression of calcium sensor proteins after repeated application of ketamine to rats Neurosci Lett 339 2003 95 98
7. H.-G. Bernstein, M. Müller The cellular localization of L-ornithine decarboxylase/polyamine system in normal and diseased central nervous systems Prog Neurobiol 57 1999 485 505
8. H.-G. Bernstein, A. Stanarius, B. Baumann, H. Henning, D. Krell, P Danos Nitric oxide synthase-containing neurons in the human hypothalamus Reduced number of immunoreactive cells in the paraventricular nucleus of depressive patients and schizophrenics Neuroscience 83 1998 867 875
9. M. Berry, P. Hubbard, A.M. Butt Cytology and lineage of NG2-positive glia J Neurocytol 31 2002 457 467
10. D. Bird, M. Bujas-Bobanovic, H.A. Robertson, S.M. Dursan Lack of phencyclidine-induced effects in mice with reduced neuronal nitric oxide synthase Psychopharmacology 155 2001 299 309
11. B. Bogerts The temporolimbic system theory of positive schizophrenic symptoms Schizophr Bull 23 1997 423 435
12. G.R. Breese, D.J. Knapp, S.S. Moy Integrative role for serotonergic and gluatamtergic receptor mechanisms in the action of NMDA antagonists Potential relationships to antipsychotic drug actions on NMDA antagonist responsiveness Neurosci Biobehav Rev 26 2002 441 455
13. J.D. Bremner, M. Narayan, E.R. Anderson, L.H. Staib, H.L. Miller, D.S. Charney Hippocampal volume reduction in major depression Am J Psychiatry 157 2000 115 118
14. J.M. Brezun, A. Daszuta Depletion in serotonin decreases neurogenesis in the dentate gyrus and the subventricular zone of adult rats Neuroscience 89 1999 999 991002
15. E. Dremencov, E. Gur, B. Lerer, M.E. Newman Effects of chronic antidepressants and electroconvulsive shock on serotonergic neurotransmission in the rat hippocampus Prog Neuropsychopharmacol Biol Psychiatry 27 2003 729 739
16. L. Dryer, P.P. Graziadei Influence of the olfactory organ on brain development Perspect Dev Neurobiol 2 1994 163 174
17. E.J. Duncan, S.H. Madonick, A. Parwani, B. Angrist, R. Rajan, S Chakravorty Clinical and sensorimotor gating effects of ketamine in normals Neuropsychopharmacology 25 2001 72 83
18. S.L. Eastwood, P.W. Burner, R. Gittins, K. Baker, P.J. Harrison Expression of serotonin 5-HAT(2A) receptors in the human cerebellum and alterations in schizophrenia Synapse 42 2001 104 114
19. C.T. Ekdahl, P. Mohapel, E. Elmer, O. Lindvall Caspase-mediated death of newly formed neurons in the adult rat dentate gyrus following status epilepticus Eur J Neurosci 16 2002 1463 1471
20. R. Gerlach, M. Beck, U. Zeitschel, V. Seifert MK 801 attenuates c-Fos and c-Jun expression after in vitro ischemia in rat neuronal cell cultures but not in PC 12 cells Neurol Res 24 2002 725 729
21. S.M. Gibbs Regulation of neuronal proliferation and differentiation by nitric oxide Mol Neurobiol 27 2003 107 120
22. E. Gould, B.S. McEwen, P. Tanapat, L.A. Galea, E. Fuchs Neurogenesis in the dendate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation J Neurosci 17 1997 2492 2498
23. E. Gould Serotonin and hippocampal neurogenesis Neuropsychopharmaology 21 suppl 2 1999 46S 51S
24. P.J. Harrison The neuropathology of schizophrenia. A critical review of the data and their interpretation Brain 122 1999 593 624
25. S. Heckers, D. Goff, A.P. Weiss Reversed hemispheric asymmetry during simple visual perception in schizophrenia Psychiatry Res 116 1-2 2002 25 32
26. S. Heckers, C. Konradi Hippocampal neurons in schizophrenia J Neural Transm 109 2002 891 905
27. Y. Hijazi, C. Bodonian, M. Bolon, F. Salord, R. Boulieu Pharmacokinetics and haemodynamics of ketamine in intensive care patients with brain or spinal cord injury Br J Anaesth 90 2003 155 160
28. M. Irifune, T. Fukuda, M. Nomoto, T. Sato, Y. Kamata, T Nishikawa Effects of ketamine on dopamine metabolism during anesthesia in discrete brain regions in mice Comparison with the effects during the recovery and subanesthetic phases Brain Res 763 1997 281 284
29. B.L. Jacobs Adult brain neurogenesis and depression Brain Behav Immun 16 2002 602 609
30. G. Juckel, J. Gallinat, M. Riedel, S. Sokullu, C. Schulz, H.J Möller Serotonergic dysfunction in schizophrenia assessed by the loudness dependence measure of primary auditory cortex evoked activity Schizophr Res 64 2003 115 124
31. L.S. Kegeles, A. Abi-Dargham, Y. Zea-Ponce, J. Rodenhiser-Hill, J.J. Mann, R.L Van Heertum Modulation of amphetamine-induced striatal dopamine release by ketamine in humans Implications for schizophrenia Biol Psychiatry 48 2000 627 640
32. G. Keilhoff, A. Becker, G. Grecksch, G. Wolf, H.G. Bernstein Repeated application of ketamine to rats induces changes in the hippocampal expression of parvalbumin, nNOS and cFOS similar to those found in human schizophrenia Neuroscience 126 2004 591 598
33. G. Kempermann Regulation of adult hippocampal neurogenesis - Implications for novel theories of major depression Bipolar Disord 4 2002 17 33
34. G. Kempermann, F.H. Gage Neurogenesis in the adult hippocampus Novartis Found Symp 231 2000 220 241
35. G. Kempermann, G. Kronenberg Depressed new neurons - adult hippocampal neurogenesis and a cellular plasticity hypothesis of major depression Biol Psychiatry 54 2003 499 503
36. H.K. Kia, M.C. Miguel, M.J. Brisorgueil, G. Daval, M. Riad, S El Mestikowy Immunocytochemical localization of serotonin 1A receptors in the rat central nervous system J Comp Neurol 365 1996 289 305
37. T. Kitamura, M. Mishina, H. Sugiyama Enhancement of neurogenesis by running wheel exercises is suppressed in mice lacking NMDA receptor ε1 subunit Neurosci Res 47 2003 55 63
38. T. Kitayama, M. Yoneyama, Y. Yoneda Possible regulation by N-methyl-D-aspartate receptors of proliferative progenitor cells expressed in adult mouse hippocampal dentate gyrus J Neurochem 84 2003 767 780
39. Z. Kokaia, O. Lindvall Neurogenesis after ischaemic brain insults Curr Opin Neurobiol 13 2003 127 132
40. S.H. Liu, J. Wang, D.Y. Zhu, Y.P. Fu, K. Lukowiak, Y.M. Lu Generation of functional inhibitory neurons in the adult rat hippocampus J Neurosci 23 2003 732 736
41. K.C. Luk, T.E. Kennedy, A.F. Sadikot Glutamate promotes proliferation of striatal neuronal progenitors by an NMDA receptor-mediated mechanism J Neurosci 23 2003 2239 2250
42. J.H. MacCabe, E. Aldouri, T.A. Fahy, P.C. Sham, R.M. Murray Do schizophrenic patients who managed to get to university have a non-developmental form of illness? Psychol Med 32 2002 535 544
43. A. Mechri, M. Saound, G. Khiari, T. d'Amato, J. Dalery, L. Gaha Glutaminergic hypothesis of schizophrenia Clinical research studies with ketamine Encephale 27 2001 53 59
44. S. Miyamoto, R.B. Mailman, J.A. Lieberman, G.E. Duncan Blunted brain metabolic response to ketamine in mice lacking D(1A) dopamine receptors Brain Res 894 2001 167 180
45. J. Nacher, G. Alonso-Llosa, D.R. Rosell, B.S. McEwan NMDA receptor antagonist treatment increases the production of new neurons in the aged rat hippocampus Neurobiol Aging 24 2003 273 284
46. E.T. Ngan, L.N. Yatham, T.J. Ruth, P.F. Liddle Decreased serotonin 2A receptor densities in neuroleptic-naive patients with schizophrenia A PET study using Am J Psychiatry 157 2000 1016 1018 [(18)F]setoperone
47. M.A. Packer, Y. Stasiv, A. Benraiss, E. Chmielnicki, A. Grinberg, H Westphal Nitric oxide negatively regulates mammalian adult neurogenesis Proc Natl Acad Sci U S A 100 2003 9566 9571
48. C. Perry Olfactory neural cells An untapped diagnostic and therapeutic resource Laryngoscope 112 2002 603 607
49. W. Schmidt, K. Reymann Proliferating cells differentiate into neurons in the hippocampal CA1 region of gerbils after global cerebral ischemia Neurosci Lett 334 2002 153 156
50. G. Tarozzo, P. Peretto, A. Fasolo Cell migration from the olfactory placode and the ontogeny of the neuroendocrine compartments Zoolog Sci 12 4 1995 367 383
51. B.I. Turetsky, P.J. Moberg, D.M. Yousem, R.L. Doty, S.E. Arnold, R.E. Gur Reduced olfactory bulb volume in patients with schizophrenia Am J Psychiatry 157 2000 828 830
52. Z. Zhang, G.P. Reynolds A selective decrease in the relative density of parvalbumin-immunoreactive neurons in the hippocampus of schizophrenia Schizophrenia Res 55 2002 1 10