Synergistic mixtures of fungitoxic monochloro and dichloro-8-quinolinols against five fungi

Mycopathologia

Volumn 158, Issue 1, 2004, Pages 131-135

  Gershon, Herman ^a   Gershon, Muriel ^a   Clarke, Donald D ^b  

^a NEW YORK BOTANICAL GARDEN   (United States)

^b FORDHAM UNIVERSITY   (United States)

Author keywords

Antifungal activity; dichloro 8 quinolinols; monochloro 8 quinolinols; steric hindrance; synergism

Indexed keywords

8 QUINOLINOL; ANTIFUNGAL AGENT; DRUG DERIVATIVE;

ARTICLE; COMPARATIVE STUDY; DEUTEROMYCETES; DRUG EFFECT; DRUG POTENTIATION; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MICROBIOLOGICAL EXAMINATION;

ANTIFUNGAL AGENTS; DRUG SYNERGISM; MICROBIAL SENSITIVITY TESTS; MITOSPORIC FUNGI; OXYQUINOLINE;

ASPERGILLUS; ASPERGILLUS NIGER; ASPERGILLUS ORYZAE; FUNGI; FUNGI IMPERFECTI; MUCOR; MUCOR CIRCINELLOIDES; MYROTHECIUM; MYROTHECIUM VERRUCARIA; TRICHODERMA; TRICHODERMA VIRIDE; VERRUCARIA;

EID: 4444267246     PISSN: 0301486X     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:MYCO.0000038427.42852.6a     Document Type: Article

References (20)

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4. What was believed over the years to be 5-iodo-8-quinolinol was found to be the 7-isomer and 7-iodo-8-quinolinol was in fact the 5- isomer [4, 5].
5. 6INO. Zeit Kristall 1997; 212: 387-388.
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7. Gershon H, Clarke DD, Gershon M. Synergistic Antifungal action of 8-quinolinol and its bischelate with copper(II) and with mixed ligand chelates composed of copper(II), 8-quinolinol, and aromatic hydroxy acids. J Pharm Sci 1989; 78: 975-978.
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9. Gershon H, Clarke DD. Improved syntheses of some monochloro- and monobromo-8-quinolinols Monatsh Chem 1991; 122: 935-941.
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12. Gershon H, Parmegiani R, Weiner A, D'Ascoli R. Fungal spore wall as a possible barrier against potential antifungal agents of the group, copper(II) complexes of 5-halogeno- and 5-nitro-8-quinolinols, Contrib Boyce Thompson Inst 1966; 23: 291-294 and references therein.
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14. Gershon H, Gershon M. Intramolecular synergism, an explanation for the enhanced Fungitoxicity of halo-8-quinolinols. Monatsh Chem 1995; 126: 1303-1309.
15. Gershon H, Clarke DD, Gershon M. Preparation and Fungitoxicity of some dichloro-8- quinolinols. Monatsh Chem 1999; 130: 653-659.
16. Gershon H, Clarke DD, McMahon JJ, Gershon M. Preparation and fungitoxicity of some dibromo-8-quinolinols. Monatsh Chem 2001; 132: 833-838.
17. Gershon H, Clarke DD, Gershon M. Preparation and fungitoxicity of some trichloro-, tribromo-, tetrachloro-, and tetrabromo-8-quinolinols. Monatsh Chem 2001; 132: 1075-1080.
18. Gershon H. Antifungal activity of bischelates of 5-, 7-, and 5,7-halogenated 8-quinolinols with copper(II). Determination of the approximate dimensions of the long and short axes of the pores in the fungal spore wall. J Med Chem 1974; 17: 824-827.
19. Gershon H, Shanks L. Reversal of fungotoxicity of 8-quinolinols and their copper(II) bischelates. Reversal of the action of 8-quinolinol by DL-α-lipoic acid. Can J Microbiol 1981; 27: 612-615.
20. Gershon H, Clarke DD, McMahon JJ. Effect of dimethylsulfoxide and dimethylformamide on the stability of 4-halo-8-quinounols. Monatsh Chem 2003; 134: 1099-1104.