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Volumn 78, Issue 9, 2004, Pages 4761-4775

Safety and Efficacy of Chimeric Yellow Fever-Dengue Virus Tetravalent Vaccine Formulations in Nonhuman Primates

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC YELLOW FEVER DENGUE VIRUS TETRAVALENT VACCINE; CHIMERIVAX DEN; COMPLEMENTARY DNA; DENGUE VACCINE; RNA; UNCLASSIFIED DRUG; YELLOW FEVER VACCINE;

EID: 4444260806     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.78.9.4761-4775.2004     Document Type: Article
Times cited : (236)

References (52)
  • 1
    • 0034896496 scopus 로고    scopus 로고
    • Yellow fever vector live-virus vaccines: West Nile vaccine development
    • Arroyo, J., C. A. Miller, J. Catalan, and T. P., Monath. 2001. Yellow fever vector live-virus vaccines: West Nile vaccine development. Trends Mol. Med. 7:329-377.
    • (2001) Trends Mol. Med. , vol.7 , pp. 329-377
    • Arroyo, J.1    Miller, C.A.2    Catalan, J.3    Monath, T.P.4
  • 2
    • 0346186973 scopus 로고    scopus 로고
    • Mutations which enhance the replication of dengue virus type 4 and an antigenic chimeric dengue virus type 2/4 vaccine candidate in Vero cells
    • Blaney, J. E., G. G. Manipon, C. Y. Firestone, D. H. Johnson, C. T. Hanson, B. R. Murphy, and S. S. Whitehead. 2003. Mutations which enhance the replication of dengue virus type 4 and an antigenic chimeric dengue virus type 2/4 vaccine candidate in Vero cells. Vaccine 21:4317-4327.
    • (2003) Vaccine , vol.21 , pp. 4317-4327
    • Blaney, J.E.1    Manipon, G.G.2    Firestone, C.Y.3    Johnson, D.H.4    Hanson, C.T.5    Murphy, B.R.6    Whitehead, S.S.7
  • 3
    • 0022638732 scopus 로고
    • Lethal 17D yellow fever encephalitis in mice. I Passive protection by monoclonal antibodies to the envelope proteins of 17D yellow fever and dengue 2 viruses
    • Brandriss, M. W., J. J. Schlesinger, E. E. Walsh, and M. Briselli. 1986. Lethal 17D yellow fever encephalitis in mice. I Passive protection by monoclonal antibodies to the envelope proteins of 17D yellow fever and dengue 2 viruses. J. Gen. Virol. 67:229-234.
    • (1986) J. Gen. Virol. , vol.67 , pp. 229-234
    • Brandriss, M.W.1    Schlesinger, J.J.2    Walsh, E.E.3    Briselli, M.4
  • 6
    • 0037044660 scopus 로고    scopus 로고
    • Adverse events associated with 17D-derived yellow fever vaccination-United States, 2001-2002
    • Centers for Disease Control and Prevention. 2002. Adverse events associated with 17D-derived yellow fever vaccination-United States, 2001-2002. Morb. Mortal. Wkly. Rep. 51:989-993.
    • (2002) Morb. Mortal. Wkly. Rep. , vol.51 , pp. 989-993
  • 7
    • 0033046765 scopus 로고    scopus 로고
    • Yellow fever/Japanese encephalitis chimeric viruses: Construction and biological properties
    • Chambers, T. J., A. Nestorowicz, P. W. Mason, K. H. Eckels, and C. M. Rice. 1999. Yellow fever/Japanese encephalitis chimeric viruses: construction and biological properties. J. Virol. 73:3095-3101.
    • (1999) J. Virol. , vol.73 , pp. 3095-3101
    • Chambers, T.J.1    Nestorowicz, A.2    Mason, P.W.3    Eckels, K.H.4    Rice, C.M.5
  • 8
    • 0037333413 scopus 로고    scopus 로고
    • Yellow fever virus/dengue-2 virus and yellow fever virus/dengue-4 virus chimeras: Biological characterization, immunogenicity, and protection against dengue encephalitis in the mouse model
    • Chambers, T. J., Y. Liang, D. A. Droll, J. J. Schlesinger, A. D. Davidson, P. J. Wright, and X. Jiang. 2003. Yellow fever virus/dengue-2 virus and yellow fever virus/dengue-4 virus chimeras: biological characterization, immunogenicity, and protection against dengue encephalitis in the mouse model. J. Virol. 77:3655-3668.
    • (2003) J. Virol. , vol.77 , pp. 3655-3668
    • Chambers, T.J.1    Liang, Y.2    Droll, D.A.3    Schlesinger, J.J.4    Davidson, A.D.5    Wright, P.J.6    Jiang, X.7
  • 10
    • 77957188470 scopus 로고
    • Behavior of 17D yellow fever virus in rhesus monkeys. Relation to substrain, dose and neural or extraneural inoculation
    • Fox J. P., and H. A. Penna. 1943. Behavior of 17D yellow fever virus in rhesus monkeys. Relation to substrain, dose and neural or extraneural inoculation. Am. J. Hyg. 38:152-172.
    • (1943) Am. J. Hyg. , vol.38 , pp. 152-172
    • Fox, J.P.1    Penna, H.A.2
  • 11
    • 0029655585 scopus 로고    scopus 로고
    • Identification of two epitopes on the dengue 4 virus capsid protein recognized by a serotype-specific and a panel of serotype-cross-reactive human CD4+ cytotoxic T-lymphocyte clones
    • Gagnon, S. J., W. Zeng, I. Kurane, and F. A. Ennis. 1996. Identification of two epitopes on the dengue 4 virus capsid protein recognized by a serotype-specific and a panel of serotype-cross-reactive human CD4+ cytotoxic T-lymphocyte clones. J. Virol. 70:141-147.
    • (1996) J. Virol. , vol.70 , pp. 141-147
    • Gagnon, S.J.1    Zeng, W.2    Kurane, I.3    Ennis, F.A.4
  • 12
    • 0037193818 scopus 로고    scopus 로고
    • Dengue: An escalating problem
    • Gibbons, R. V., and D. W. Vaughn. 2002. Dengue: an escalating problem. Br. Med. J. 324:1563-1566.
    • (2002) Br. Med. J. , vol.324 , pp. 1563-1566
    • Gibbons, R.V.1    Vaughn, D.W.2
  • 13
    • 0002540391 scopus 로고    scopus 로고
    • Dengue and dengue hemorrhagic fever: Its history and resurgence as a global public health problem
    • D. J. Gubler and G. Kuno (ed.). CABI Publishing, New York, NY
    • Gubler, D. J. 1997. Dengue and dengue hemorrhagic fever: its history and resurgence as a global public health problem, p. 1-22. In D. J. Gubler and G. Kuno (ed.), Dengue and dengue hemorrhagic fever. CABI Publishing, New York, NY.
    • (1997) Dengue and Dengue Hemorrhagic Fever , pp. 1-22
    • Gubler, D.J.1
  • 15
    • 0036304311 scopus 로고    scopus 로고
    • Viremia and immunogenicity in nonhuman primates of a tetravalent yellow fever-dengue chimeric vaccine: Genetic reconstructions, dose adjustment, and antibody responses against wild-type dengue virus isolates
    • Guirakhoo, F., K. Pugachev, J. Arroyo, C. Miller, Z.-X. Zhang, R. Weltzin, K. Georgakopoulos, J. Catalan, S. Ocran, K. Draper, and T. P. Monath. 2002. Viremia and immunogenicity in nonhuman primates of a tetravalent yellow fever-dengue chimeric vaccine: genetic reconstructions, dose adjustment, and antibody responses against wild-type dengue virus isolates. Virology 298:146-159.
    • (2002) Virology , vol.298 , pp. 146-159
    • Guirakhoo, F.1    Pugachev, K.2    Arroyo, J.3    Miller, C.4    Zhang, Z.-X.5    Weltzin, R.6    Georgakopoulos, K.7    Catalan, J.8    Ocran, S.9    Draper, K.10    Monath, T.P.11
  • 17
    • 0033541937 scopus 로고    scopus 로고
    • Immunogenicity, genetic stability, and protective efficacy of a recombinant, chimeric yellow fever-Japanese encephalitis virus (ChimeriVax™-JE) as a live, attenuated vaccine candidate against Japanese encephalitis
    • Guirakhoo, F., Z.-X. Zhang, T. J. Chambers, S. Delagrave, J. Arroyo, A. D. T. Barrett, and T. P. Monath. 1999. Immunogenicity, genetic stability, and protective efficacy of a recombinant, chimeric yellow fever-Japanese encephalitis virus (ChimeriVax™-JE) as a live, attenuated vaccine candidate against Japanese encephalitis. Virology 257:363-372.
    • (1999) Virology , vol.257 , pp. 363-372
    • Guirakhoo, F.1    Zhang, Z.-X.2    Chambers, T.J.3    Delagrave, S.4    Arroyo, J.5    Barrett, A.D.T.6    Monath, T.P.7
  • 18
    • 0023818748 scopus 로고
    • Pathogenesis of dengue: Challenges to molecular biology
    • Halstead, S. B. 1988. Pathogenesis of dengue: challenges to molecular biology. Science 239:476-481.
    • (1988) Science , vol.239 , pp. 476-481
    • Halstead, S.B.1
  • 19
    • 0002666915 scopus 로고
    • Susceptibility and resistance of vector mosquitoes, p
    • T. P. Monath (ed.). CRC, Inc., Boca Raton, Fla.
    • Hardy, J. L. 1988. Susceptibility and resistance of vector mosquitoes, p 87-126. In T. P. Monath (ed.). The arboviruses: ecology and epidemiology, vol. 1. CRC, Inc., Boca Raton, Fla.
    • (1988) The Arboviruses: Ecology and Epidemiology , vol.1 , pp. 87-126
    • Hardy, J.L.1
  • 20
  • 21
    • 0033850655 scopus 로고    scopus 로고
    • Potential dengue virus-triggered apoptotic pathway in human neuroblastoma cells: Arachidonic acid, superoxide anion, and NF-kappaB are sequentially involved
    • Jan, J.-T., B.-H. Chen, S.-H. Ma, C.-I. Liu, H.-P. Tsai, H.-C. Wu, S.-Y. Jiang, K.-D. Yuang, and M.-F. Shaio. 2000. Potential dengue virus-triggered apoptotic pathway in human neuroblastoma cells: arachidonic acid, superoxide anion, and NF-kappaB are sequentially involved. J. Virol. 74:8680-8691.
    • (2000) J. Virol. , vol.74 , pp. 8680-8691
    • Jan, J.-T.1    Chen, B.-H.2    Ma, S.-H.3    Liu, C.-I.4    Tsai, H.-P.5    Wu, H.-C.6    Jiang, S.-Y.7    Yuang, K.-D.8    Shaio, M.-F.9
  • 22
    • 1542349168 scopus 로고    scopus 로고
    • Analysis of the replication kinetics of the ChimeriVax™-DEN 1,2,3, 4 tetravalent virus mix in Aedes aegypti by real-time reverse transcriptase-polymerase chain reaction
    • Johnson, B. W., T. V. Chambers, M. B. Crabtree, F. Guirakhoo, T. P. Monath, and B. R. Miller. 2004. Analysis of the replication kinetics of the ChimeriVax™-DEN 1,2,3,4 tetravalent virus mix in Aedes aegypti by real-time reverse transcriptase-polymerase chain reaction. Am. J. Trop. Med. Hyg. 70:89-97.
    • (2004) Am. J. Trop. Med. Hyg. , vol.70 , pp. 89-97
    • Johnson, B.W.1    Chambers, T.V.2    Crabtree, M.B.3    Guirakhoo, F.4    Monath, T.P.5    Miller, B.R.6
  • 24
    • 0024565393 scopus 로고
    • Antibody-dependent enhancement of dengue virus growth in human monocytes as a risk factor for dengue hemorrhagic fever
    • Kliks, S. C., A. Nisalak, W. E. Brandt, L. Wahl, and D. S. Burke. 1989. Antibody-dependent enhancement of dengue virus growth in human monocytes as a risk factor for dengue hemorrhagic fever. Am. J. Trop. Med. Hyg. 40:444-451.
    • (1989) Am. J. Trop. Med. Hyg. , vol.40 , pp. 444-451
    • Kliks, S.C.1    Nisalak, A.2    Brandt, W.E.3    Wahl, L.4    Burke, D.S.5
  • 26
    • 0023603238 scopus 로고
    • The monkey safety test for neurovirulence of yellow fever vaccines: The utility of quantitative clinical evaluation and histological examination
    • Levenbook, I. S., L. J., Pelleu, and B. L. Elisberg. 1987. The monkey safety test for neurovirulence of yellow fever vaccines: the utility of quantitative clinical evaluation and histological examination. J. Biol. Stand. 15:305-313.
    • (1987) J. Biol. Stand. , vol.15 , pp. 305-313
    • Levenbook, I.S.1    Pelleu, L.J.2    Elisberg, B.L.3
  • 28
    • 0028888835 scopus 로고
    • Dengue virus-specific, HLA-B35-restricted, human CD8+ cytotoxic T lymphocyte (CTL) clones. Recognition of NS3 amino acids 500 to 508 by CTL clones of two different serotype specificities
    • Livingston, P. G., I. Kurane, L. C. Dai, Y. Okamoto, C. L. Lai, R. Men, S. Karaki, M. Takiguchi, and F. A. Ennis. 1995. Dengue virus-specific, HLA-B35-restricted, human CD8+ cytotoxic T lymphocyte (CTL) clones. Recognition of NS3 amino acids 500 to 508 by CTL clones of two different serotype specificities. J. Immunol. 154:1287-1295.
    • (1995) J. Immunol. , vol.154 , pp. 1287-1295
    • Livingston, P.G.1    Kurane, I.2    Dai, L.C.3    Okamoto, Y.4    Lai, C.L.5    Men, R.6    Karaki, S.7    Takiguchi, M.8    Ennis, F.A.9
  • 30
    • 0242289408 scopus 로고    scopus 로고
    • Neurovirulence of yellow fever 17DD vaccine virus to rhesus monkeys
    • Marchevsky, R. S., M. S. Freire, E. S. Coutinho, and R. Galler. 2003. Neurovirulence of yellow fever 17DD vaccine virus to rhesus monkeys. Virology 316:55-63.
    • (2003) Virology , vol.316 , pp. 55-63
    • Marchevsky, R.S.1    Freire, M.S.2    Coutinho, E.S.3    Galler, R.4
  • 31
    • 0035198383 scopus 로고    scopus 로고
    • Advanced age a risk factor for illness temporally associated with yellow fever vaccination
    • Martin, M., L. H. Weld, T. F. Tsai, G. T. Mootrey, R. T. Chen, M. Niu, M. S. Cetron, and the GeoSentinel Yellow Fever Working Group. 2001. Advanced age a risk factor for illness temporally associated with yellow fever vaccination. Emerg. Infect. Dis. 7:945-951.
    • (2001) Emerg. Infect. Dis. , vol.7 , pp. 945-951
    • Martin, M.1    Weld, L.H.2    Tsai, T.F.3    Mootrey, G.T.4    Chen, R.T.5    Niu, M.6    Cetron, M.S.7
  • 33
    • 0033838835 scopus 로고    scopus 로고
    • Dengue viral infections; pathogenesis and epidemiology
    • McBride, W. J., and H. Bielefeldt-Ohmann. 2000. Dengue viral infections; pathogenesis and epidemiology. Microbes Infect. 2:1041-1050.
    • (2000) Microbes Infect. , vol.2 , pp. 1041-1050
    • McBride, W.J.1    Bielefeldt-Ohmann, H.2
  • 34
    • 0028355518 scopus 로고
    • Dengue-the risk to developed and developing countries
    • Monath, T. P. 1994. Dengue-the risk to developed and developing countries. Proc. Natl. Acad. Sci. USA 91:2395-2400.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 2395-2400
    • Monath, T.P.1
  • 35
    • 0141537467 scopus 로고    scopus 로고
    • Chimeric live, attenuated vaccine against Japanese encephalitis (ChimeriVax-JE): Phase 2 clinical trials for safety and immunogenicity, effect of vaccine dose and schedule, and memory response to challenge with inactivated Japanese encephalitis antigen
    • Monath, T. P., F. Guirakhoo, R. Nichols, S. Yoksan, R. Schrader, C. Murphy, P. Blum, S. Woodward, K. McCarthy, D. Mathis, C. Johnson, and P. Bedford. 2003. Chimeric live, attenuated vaccine against Japanese encephalitis (ChimeriVax-JE): phase 2 clinical trials for safety and immunogenicity, effect of vaccine dose and schedule, and memory response to challenge with inactivated Japanese encephalitis antigen. J. Infect. Dis. 188:1213-1230.
    • (2003) J. Infect. Dis. , vol.188 , pp. 1213-1230
    • Monath, T.P.1    Guirakhoo, F.2    Nichols, R.3    Yoksan, S.4    Schrader, R.5    Murphy, C.6    Blum, P.7    Woodward, S.8    McCarthy, K.9    Mathis, D.10    Johnson, C.11    Bedford, P.12
  • 37
    • 0036148484 scopus 로고    scopus 로고
    • Single mutation in the flavivirus envelope protein hinge region increases neurovirulence for mice and monkeys but decreases viscerotropism for monkeys: Relevance to development and safety testing of live, attenuated vaccines
    • Monath, T. P., J. Arroyo, I. Levenbook, Z.-X. Zheng, J. Catalan, K. Draper, and F. Guirakhoo. 2002. Single mutation in the flavivirus envelope protein hinge region increases neurovirulence for mice and monkeys but decreases viscerotropism for monkeys: relevance to development and safety testing of live, attenuated vaccines. J. Virol. 76:1932-1943.
    • (2002) J. Virol. , vol.76 , pp. 1932-1943
    • Monath, T.P.1    Arroyo, J.2    Levenbook, I.3    Zheng, Z.-X.4    Catalan, J.5    Draper, K.6    Guirakhoo, F.7
  • 39
    • 0033538089 scopus 로고    scopus 로고
    • Recombinant, chimaeric live, attenuated vaccine (ChimeriVax) incorporating the envelope genes of Japanese encephalitis (SA14-14-2) virus and the capsid and nonstructural genes of yellow fever (17D) virus is safe, immunogenic and protective in non-human primates
    • Monath, T. P., K. Soike, I. Levenbook, Z.-X. Zhang, J. Arroyo, S. Delagrave, G. Myers, A. D. Barrett, R. E. Shope, M. Ratterree, T. J. Chambers, and F. Guirakhoo. 1999. Recombinant, chimaeric live, attenuated vaccine (ChimeriVax) incorporating the envelope genes of Japanese encephalitis (SA14-14-2) virus and the capsid and nonstructural genes of yellow fever (17D) virus is safe, immunogenic and protective in non-human primates. Vaccine 17:1869-1882.
    • (1999) Vaccine , vol.17 , pp. 1869-1882
    • Monath, T.P.1    Soike, K.2    Levenbook, I.3    Zhang, Z.-X.4    Arroyo, J.5    Delagrave, S.6    Myers, G.7    Barrett, A.D.8    Shope, R.E.9    Ratterree, M.10    Chambers, T.J.11    Guirakhoo, F.12
  • 40
    • 17544377861 scopus 로고    scopus 로고
    • Experimental infection of monkeys with Langat virus. II. Turnover of circulating virus
    • Nathanson, N., and B. Harrington. 2000. Experimental infection of monkeys with Langat virus. II. Turnover of circulating virus. Rev. Med. Virol. 10:207-215.
    • (2000) Rev. Med. Virol. , vol.10 , pp. 207-215
    • Nathanson, N.1    Harrington, B.2
  • 41
    • 0003633755 scopus 로고    scopus 로고
    • Department of Health and Human Services publication (NIH) 85-23. National Institutes of Health, Bethesda, Md.
    • National Institutes of Health. 1998. Guide for the care and use of laboratory animals, rev. ed. Department of Health and Human Services publication (NIH) 85-23. National Institutes of Health, Bethesda, Md.
    • (1998) Guide for the Care and Use of Laboratory Animals, Rev. Ed.
  • 42
    • 0023094323 scopus 로고
    • Passive immunization of mice with monoclonal antibodies raised against tick-borne encephalitis virus. Brief report
    • Phillpotts, R. J., J. R. Stephenson, and J. S. Porterfield. 1987. Passive immunization of mice with monoclonal antibodies raised against tick-borne encephalitis virus. Brief report. Arch. Virol. 93:295-301.
    • (1987) Arch. Virol. , vol.93 , pp. 295-301
    • Phillpotts, R.J.1    Stephenson, J.R.2    Porterfield, J.S.3
  • 43
    • 0034864644 scopus 로고    scopus 로고
    • Tick-borne Langat/mosquito-borne dengue flavivirus chimera, a candidate live attenuated vaccine for protection against disease caused by members of the tick-borne encephalitis virus complex: Evaluation in rhesus monkeys and in mosquitoes
    • Pletnev, A. G., M. Bray, K. A. Hanley, J. Speicher, and R. Elkins. 2001. Tick-borne Langat/mosquito-borne dengue flavivirus chimera, a candidate live attenuated vaccine for protection against disease caused by members of the tick-borne encephalitis virus complex: evaluation in rhesus monkeys and in mosquitoes. Virology 75:8259-8267.
    • (2001) Virology , vol.75 , pp. 8259-8267
    • Pletnev, A.G.1    Bray, M.2    Hanley, K.A.3    Speicher, J.4    Elkins, R.5
  • 44
    • 0037022604 scopus 로고    scopus 로고
    • West Nile virus/dengue type 4 virus chimeras that are reduced in neurovirulence and peripheral virulence without loss of immunogenicity or protective efficacy
    • Erratum, 99:7184
    • Pletnev, A. G., R. Putnak, J. Speicher, E. J. Wagar, and D. W. Vaughn. 2002. West Nile virus/dengue type 4 virus chimeras that are reduced in neurovirulence and peripheral virulence without loss of immunogenicity or protective efficacy. Proc. Natl. Acad. Sci. USA 99:3036-3041. (Erratum, 99:7184.)
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 3036-3041
    • Pletnev, A.G.1    Putnak, R.2    Speicher, J.3    Wagar, E.J.4    Vaughn, D.W.5
  • 48
    • 0033887510 scopus 로고    scopus 로고
    • Chimeric yellow fever/dengue virus as a candidate dengue vaccine: Quantitation of the dengue virus-specific CD8 T-cell response
    • van der Most, R. G., K. Murali-Krishna, R. Ahmed, and J. H. Strauss. 2000. Chimeric yellow fever/dengue virus as a candidate dengue vaccine: quantitation of the dengue virus-specific CD8 T-cell response. J. Virol. 74:8094-8101.
    • (2000) J. Virol. , vol.74 , pp. 8094-8101
    • Van Der Most, R.G.1    Murali-Krishna, K.2    Ahmed, R.3    Strauss, J.H.4
  • 49
    • 0346817393 scopus 로고    scopus 로고
    • Substitution of the structural genes of dengue virus type 4 with those of type 2 results in chimeric vaccine candidates which are attenuated for mosquitoes, mice, and rhesus monkeys
    • Whitehead, S. S., K. A. Hanley, J. E. Blaney, L. E. Gilmore, W. R. Elkins, and B. R. Murphy. 2003. Substitution of the structural genes of dengue virus type 4 with those of type 2 results in chimeric vaccine candidates which are attenuated for mosquitoes, mice, and rhesus monkeys. Vaccine 21:4307-4316.
    • (2003) Vaccine , vol.21 , pp. 4307-4316
    • Whitehead, S.S.1    Hanley, K.A.2    Blaney, J.E.3    Gilmore, L.E.4    Elkins, W.R.5    Murphy, B.R.6
  • 50
    • 0003415212 scopus 로고    scopus 로고
    • Requirements for yellow fever vaccine (requirements for biological substances no. 3.)
    • World Health Organization. 1998. Requirements for yellow fever vaccine (requirements for biological substances no. 3.). W.H.O. Tech. Rep. Ser. 872:30-65.
    • (1998) W.H.O. Tech. Rep. Ser. , vol.872 , pp. 30-65
  • 51
    • 16544368979 scopus 로고    scopus 로고
    • World Health Organization, Geneva, Switzerland
    • World Health Organization. 2002. WHO fact sheet 117. World Health Organization, Geneva, Switzerland.
    • (2002) WHO Fact Sheet 117
  • 52
    • 0024442728 scopus 로고
    • Passive protection of mice, goats, and monkeys against Japanese encephalitis with monoclonal antibodies
    • Zhang, M., M. Wang, S. Jiang, and W. Ma. 1989. Passive protection of mice, goats, and monkeys against Japanese encephalitis with monoclonal antibodies. J. Med. Virol. 29:133-138.
    • (1989) J. Med. Virol. , vol.29 , pp. 133-138
    • Zhang, M.1    Wang, M.2    Jiang, S.3    Ma, W.4


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