Toxicity of a cyanobacterial extract containing microcystins to mouse lungs

Brazilian Journal of Medical and Biological Research

Volumn 37, Issue 8, 2004, Pages 1225-1229

  Picanco M R ^a   Soares, R M ^a   Cagido, V R ^a   Azevedo, S M F O ^a   Rocco, P R M ^a   Zin, W A ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Alveolar collapse; Inflammation; Lung; Microcystins

Indexed keywords

CYANOGINOSIN; CYCLOPEPTIDE; EOSIN; HEMATOXYLIN; HEPTAPEPTIDE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL COUNT; CLINICAL OBSERVATION; CONTROLLED STUDY; CYANOBACTERIUM; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACTION; HISTOLOGY; INFLAMMATORY INFILTRATE; INJECTION; LETHAL DOSE; LIVER TOXICITY; LUNG ALVEOLUS; LUNG COLLAPSE; LUNG TOXICITY; MALE; MONONUCLEAR CELL; MOUSE STRAIN; NONHUMAN; POLYMORPHONUCLEAR CELL; RAT; TISSUE SECTION;

ANIMALIA; CYANOBACTERIA;

EID: 4444259052     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2004000800013     Document Type: Article

References (20)

1. Carmichael WW (1994). The toxins of cyanobacteria. Scientific American, 270: 78-86.
2. Chorus I & Bartram J (1999). Toxic Cyanobacteria in Water - A Guide to Their Public Health Consequences, Monitoring and Management. E & FN Spon, London, UK.
3. Falconer I & Humpage A (1996). Tumour promotion by cyanobacterial toxins. Phycologia, 35: 74-79.
4. Naseem SM, Hines HB & Creasia DA (1990). Inhibition of microcystin-induced release of cyclooxygenase products from rat hepatocytes by anti-inflammatory steroids. Proceedings of the Society for Experimental Biology and Medicine, 195: 345-349.
5. Falconer IR, Beresford AM & Runnegar MTC (1983). Evidence of liver damage by toxin from a bloom of the blue-green algae, Microcystis aeruginosa. Medical Journal of Australia, 1: 511-514.
6. Teixeira MdaG, Costa MdaC, Carvalho VLP, Pereira MS & Hage E (1993). Gastroenteritis epidemic in the area of the Itaparica dam, Bahia, Brazil. Bulletin of the Pan American Health Organization, 27: 244-253.
7. Jochimsen EM, Carmichael WW, An J et al. (1998). Liver failure and death after exposure to microcystins at a haemodialysis center in Brazil. New England Journal of Medicine, 33: 873-878.
8. Carmichael WW, Azevedo SMFO, An J, Molica RJR, Jochimsen EM, Lau S, Rinehart KL, Shaw GR & Eaglesham GK (2001). Human fatalities from cyanobacteria: chemical and biological evidence for cyanotoxins. Environmental Health Perspectives, 109: 663-668.
9. Azevedo SMFO, Carmichael WW, Jochimsen EM, Rinehart KL, Lau S, Shaw GR & Eaglesham GK (2002). Human intoxication by microcystins during renal dialysis treatment in Caruaru - Brazil. Toxicology, 181: 441-446.
10. Fitzgeorge RB, Clark SA & Kelvin CW (1994). Routes of intoxication. In: Codd GA, Jeffries TM, Kelvin CW & Potter E (Editors), Detection Methods for Cyanobacterial (Blue-Green Algae) Toxins, The Royal Society of Chemistry, Cambridge, UK.
11. Turner PC, Gammie AJ, Hollinrake K, Codd GA (1990). Pneumonia associated with cyanobacteria. British Medical Journal, 300: 1400-1441.
12. Slatkin DN, Stoner RD, Adams WH, Kycia JH & Siegelman HW (1983). Atypical pulmonary thrombosis caused by a toxic cyanobacterial peptide. Science, 220: 1383-1385.
13. Ito E, Kondo F & Harada K-I (2000). First report on the distribution of orally administered microcystin-LR in mouse tissue using an immunostaining method. Toxicon, 38: 37-48.
14. Ito E, Kondo F & Harada K-I (2001). Intratracheal administration of microcystin-LR, and its distribution. Toxicon, 39: 265-271.
15. Ferrão-Filho AS & Azevedo SMFO (2002). Effects of unicellular and colonial forms of toxic Microcystis aeruginosa from laboratory cultures and natural populations on tropical cladocerans. Aquatic Ecology, 37: 23-35.
16. Azevedo SMFO, Evans WR, Carmichael WW & Namikoshi M (1994). First report of microcystins from a Brazilian isolate of the cyanobacterium Microcystis aeruginosa. Journal of Applied Phycology, 6: 261-265.
17. Nagase T, Lei M, Robatto FM, Eidelman DH & Ludwig MS (1992). Tissue viscance during induced constriction in rabbit lung: morphological-physiological correlation. Journal of Applied Physiology, 73: 1900-1907.
18. Weibel ER (1990). Morphometry: stereological theory and practical methods. In: Gil J (Editor), Models of Lung Disease - Microscopy and Structural Methods. Marcel Dekker, New York.
19. Naseem SM, Hines HB & Creasia DA (1989). Effect of toxins on arachidonic acid metabolism in rat cultured pulmonary alveolar macrophages. Biochemistry International, 19: 583-592.
20. Nakano Y, Shirai M, Mori N & Nakano M (1991). Neutralization of microcystin shock in mice by tumor necrosis factor alpha antiserum. Applied and Environmental Microbiology, 57: 327-330.