Selective suppression of chemokine receptor CXCR3 expression by interferon-β1a in multiple sclerosis

Multiple Sclerosis

Volumn 8, Issue 2, 2002, Pages 104-107

  Sorensen T L ^a   Sellebjerg, F ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Chemokine receptors; Chemokines; Demyelinating disease; Multiple sclerosis; Neuroimmunology

Indexed keywords

BETA1A INTERFERON; CD14 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CHEMOKINE RECEPTOR CCR1; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR3; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR3; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES;

ADULT; ARTICLE; BLOOD; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CONTROLLED STUDY; DEMYELINATING DISEASE; DRUG BLOOD LEVEL; DRUG MECHANISM; FEMALE; HUMAN; MALE; MONOCYTE; MULTIPLE SCLEROSIS; NEUROIMMUNOLOGY; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; T LYMPHOCYTE;

ADULT; BIOLOGICAL RESPONSE MODIFIERS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DISABILITY EVALUATION; DOWN-REGULATION; FEMALE; HUMANS; INTERFERON-BETA; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; RECEPTORS, CHEMOKINE; T-LYMPHOCYTE SUBSETS; TIME FACTORS;

EID: 4444251943     PISSN: 13524585     EISSN: None     Source Type: Journal    
DOI: 10.1191/1352458502ms781oa     Document Type: Article

References (13)

1. Progress in determining the causes and treatment of multiple sclerosis
2. Interferon beta in the treatment of multiple sclerosis: Mechanisms of action
3. Cerebrospinal fluid abnormalities in a phase III trial of Avonex (IFNbeta-1a) for relapsing multiple sclerosis
4. Chemokines and leukocyte traffic
5. Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients
6. CCR5+ and CXCR3+ T cells are increased in multiple sclerosis and their ligands MIP-1alfa and IP-10 are expressed in demyelinating brain lesions
7. RANTES production and expression is reduced in relapsing remitting multiple sclerosis patients treated with interferon beta-1b
8. Chemokine-enhanced migration of human peripheral blood mononuclear cells is antagonized by interferon beta-1b through an effect on matrix metalloproteinase-9
9. Increased number of CCR5+ interferon-gamm- and tumor necrosis factor-alpha secreting T lymphocytes in multiple sclerosis patients
10. CCR5Δ32, matrix metalloproteinase-9 and disease activity in multiple sclerosis
11. Interferon beta results in immediate reduction of contrast-enhanced MRI lesions in multiple sclerosis patients followed by weekly MRI
12. Regulation of chemokine receptor CCR5 and production of RANTES and MIP-1alpha by interferon-beta
13. Seasonal variation of interferon-gamma production in progressive multiple sclerosis