2-Pyrazolyl-n6-substituted adenosine derivatives as high affinity and selective adenosine A3 receptor agonists

Journal of Medicinal Chemistry

Volumn 47, Issue 19, 2004, Pages 4766-4773

  Elzein, Elfatih ^a   Palle, Venkata ^a   Wu, Yuzhi ^a   Maa, Tenning ^a   Zeng, Dewan ^a   Zablocki, Jeff ^a  

^a CV THERAPEUTICS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [9 [TETRAHYDRO 3,4 DIHYDROXY 5 (HYDROXYMETHYL)FURAN 2 YL] 6 (METHYLAMINO) 9H PURIN 2 YL] N METHYL 1H PYRAZOLE 4 CARBOXAMIDE; 2 PYRAZOLYLADENOSINE DERIVATIVE; [9 [3,4 BIS(1,1,2,2 TETRAMETHYL 1 SILAPROPOXY) 5 [(1,1,2,2 TETRAMETHYL 1 SILAPROPOXY)METHYL]OXAN 2 YL] 2 (1 BENZYLPYRAZOL 4 YL)PURIN 6 YL]PROPYLAMINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE A3 RECEPTOR AGONIST; ADENOSINE DERIVATIVE; METHYL GROUP; TETRAHYDRO 2 (HYDROXYMETHYL) 5 [6 (METHYLAMINO) 2 [4 (PYRIDIN 2 YL) 1H PYRAZOL 1 YL] 9H PURIN 9 YL]FURAN 3 DIOL; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING KINETICS; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; MATHEMATICAL ANALYSIS; NONHUMAN;

ADENOSINE; ANIMALS; CRICETINAE; HUMANS; MOLECULAR STRUCTURE; RECEPTOR, ADENOSINE A3; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 4444224473     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049682h     Document Type: Article

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