Complex assembly mechanism and an RNA-binding mode of the human p14-SF3b155 spliceosomal protein complex identified by NMR solution structure and functional analyses

Proteins: Structure, Function and Genetics

Volumn 71, Issue 4, 2008, Pages 1617-1636

  Kuwasako, Kanako ^a   Dohmae, Naoshi ^b   Inoue, Mio ^a   Shirouzu, Mikako ^a,c   Taguchi, Seiichi ^d   Güntert, Peter ^a   Séraphin, Bertrand ^e   Muto, Yutaka ^a   Yokoyama, Shigeyuki ^a,f  

^a RIKEN YOKOHAMA INSTITUTE   (Japan)

^b RIKEN   (Japan)

^c Harima Institute ^*  (Japan)

^d HOKKAIDO UNIVERSITY   (Japan)

^e CENTRE DE GÉNÉTIQUE MOLÉCULAIRE   (France)

^f UNIVERSITY OF TOKYO   (Japan)

Author keywords

NMR; p14; RRM; SF3b155; U2 snRNP

Indexed keywords

AMINO ACID; DNA FRAGMENT; PROTEIN P14;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CRYSTALLOGRAPHY; DELETION MUTANT; HYDROPHOBICITY; MOLECULAR MECHANICS; MOLECULAR RECOGNITION; MUTAGENESIS; NUCLEAR LOCALIZATION SIGNAL; NUCLEAR MAGNETIC RESONANCE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; RESIDUE ANALYSIS; RNA BINDING; SPLICEOSOME;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITES; CELL NUCLEUS; DNA, COMPLEMENTARY; GLUTATHIONE TRANSFERASE; HISTIDINE; HUMANS; HYDROLYSIS; HYDROPHOBICITY; LEUCINE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR LOCALIZATION SIGNALS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHENYLALANINE; PHOSPHOPROTEINS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; RIBONUCLEOPROTEIN, U2 SMALL NUCLEAR; RIBONUCLEOPROTEINS; RNA SPLICING; SEQUENCE HOMOLOGY, AMINO ACID; SPLICEOSOMES; TRYPSIN; TYROSINE; VALINE;

EID: 44349194811     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.21839     Document Type: Article

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