Cl-channel blockers inhibit cell proliferation and arrest the cell cycle of human ovarian cancer cells

European Journal of Gynaecological Oncology

Volumn 29, Issue 3, 2008, Pages 267-271

  Li, M ^a   Wang, B ^a   Lin, W ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Cell cycle; Cell proliferation; Chloride channels; Ovarian cancer

Indexed keywords

ANTIMITOTIC AGENT; CHLORIDE CHANNEL; GLIBENCLAMIDE; NIFLUMIC ACID; NITROBLUE TETRAZOLIUM; PROPIDIUM IODIDE; VOLTAGE GATED CHLORIDE CHANNEL; VOLUME SENSITIVE CHLORIDE CHANNEL;

ARTICLE; CALCIUM TRANSPORT; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL PROLIFERATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; OVARY CANCER; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VOLTAGE CLAMP;

CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CHLORIDE CHANNELS; FEMALE; HUMANS; OVARIAN NEOPLASMS;

EID: 44349158286     PISSN: 03922936     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. O'Grady S.M., Jiang X., Ingbar D.H.: "Cl-channel activation is necessary for stimulation of Na transport in adult alveolar epithelial cells". Am. J. Physiol. Lung Cell. Mol. Physiol., 2000, 278, L239.
2. Nilius B., Eggermont J., Voets T., Buyse G., Manolopoulos V., Droogmans G.: "Properties of volume-regulated anion channels in mammalian cells". Prog. Biophys. Mol. Biol., 1997, 68, 69.
3. Valverde M.A.: "ClC channels: leaving the dark ages on the verge of a new millennium". Curr. Opin. Cell. Biol., 1999, 11, 509.
4. Li X., Wang T., Zhao Z., Weinman S.A.: "The CLC-3 chloride channel promotes acidification of lysosomes in CHO-K1 and Huh-7 cells". Am. J. Physiol. Cell. Physiol., 2002, 282, C1483.
5. Voets T., Szücs G., Droogmans G., Nilius B.: "Blockers of volume-activated Cl-currents inhibit endothelial cell proliferation". Pflugers Arch., 1995, 431, 132.
6. Wondergem R., Gong W., Monen S.H., Dooley S.N., Gonce J.L., Conner T.D. et al.: "Blocking swelling-activated chloride current inhibits mouse liver cell proliferation". J. Physiol., 2001, 532, 661.
7. Nilius B.: "Chloride channels go cell cycling". J. Physiol., 2001, 532, 581.
8. Chen L., Wang L., Zhu L., Nie S., Zhang J., Zhong P. et al.: "Cell cycle-dependent expression of volume-activated chloride currents in nasopharyngeal carcinoma cells". Am. J. Physiol. Cell. Physiol., 2002, 283, C1313.
9. Jiang B., Hattori N., Liu B., Nakayama Y., Kitagawa K., Inagaki C.: "Suppression of cell proliferation with induction of p21 by C1 (-) channel blockers in human leukemic cells". Eur. J. Pharmacol., 2004, 488, 27.
10. Chen L.X., Zhu L.Y., Jacob T.J., Wang L.W.: "Roles of volume-activated Cl-currents and regulatory volume decrease in the cell cycle and proliferation in nasopharyngeal carcinoma cells". Cell. Prolif., 2007, 40, 253.
11. Shen M.R., Droogmans G., Eggermont J., Voets T., Ellory J.C., Nilius B.: "Differential expression of volume-regulated anion channels during cell cycle progression of human cervical cancer cells". J. Physiol., 2000, 529, 385.
12. Ferlini C., Scambia G., Marone M., Distefano M., Gaggini C., Ferrandina G. et al.: "Tamoxifen induces oxidative stress and apoptosis in oestrogen receptor-negative human cancer cell lines". Br. J. Cancer, 1999, 79, 257.
13. Suzuki M., Morita T., Iwamoto T.: "Diversity of Cl (-) channels". Cell. Mol. Life Sci, 2006, 63, 12.
14. Duffy S.M., Lawley W.J., Kaur D., Yang W., Bradding P.: "Inhibition of human mast cell proliferation and survival by tamoxifen in association with ion channel modulation". J. Allergy Clin. Immunol., 2003, 112, 965.
15. Bösl M.R., Stein V., Hübner C., Zdebik A.A., Jordt S.E., Mukhopadhyay A.K. et al.: "Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2 Cl (-) channel disruption". EMBO J., 2001, 20, 1289.
16. Zheng Y.J., Furukawa T., Tajimi K., Inagaki N.: "Cl-channel blockers inhibit transition of quiescent (G0) fibroblasts into the cell cycle". J. Cell. Physiol., 2003, 194, 376.
17. Pappas C.A., Ullrich N., Sontheimer H.: "Reduction of glial proliferation by K+ channel blockers is mediated by changes in pHi". Neuroreport, 1994, 6, 193.
18. Hara-Chikuma M., Yang B., Sonawane N.D., Sasaki S., Uchida S., Verkman A.S.: "ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation". J. Biol. Chem., 2005, 280, 1241.
19. Santella L.: "The role of calcium in the cell cycle: facts and hypotheses". Biochem. Biophys Res. Commun., 1998, 244, 317.
20. Parmer T.G., Ward M.D., Hait W.N.: "Effects of rottlerin, an inhibitor of calmodulin-dependent protein kinase III, on cellular proliferation, viability, and cell cycle distribution in malignant glioma cells". Cell. Growth Differ., 1997, 8, 327.
21. Parmer T.G., Ward M.D., Yurkow E.J., Vyas V.H., Kearney T.J., Hait W.N.: "Activity and regulation by growth factors of calmodulin-dependent protein kinase III (elongation factor 2-kinase) in human breast cancer". Br. J. Cancer, 1999, 79, 59.