Radiotherapy to Improve Local Control Regardless of Surgical Margin and Malignancy Grade in Extremity and Trunk Wall Soft Tissue Sarcoma: A Scandinavian Sarcoma Group Study

International Journal of Radiation Oncology Biology Physics

Volumn 71, Issue 4, 2008, Pages 1196-1203

  Jebsen, Nina L ^a,b   Trovik, Clement S ^b   Bauer, Henrik C F ^c   Rydholm, Anders ^d   Monge, Odd R ^b   Hall, Kirsten Sundby ^e   Alvegård, Thor ^d   Bruland, Øyvind S ^e,f  

^a UNIVERSITY OF BERGEN   (Norway)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d LUND UNIVERSITY HOSPITAL   (Sweden)

^e OSLO UNIVERSITY HOSPITAL   (Norway)

^f UNIVERSITY OF OSLO   (Norway)

Author keywords

Adjuvant radiotherapy; Local recurrence; Soft tissue sarcoma; Surgical margin

Indexed keywords

ELECTROTHERAPEUTICS; ONCOLOGY; PHOTOACOUSTIC EFFECT; PIGMENTS; RADIOTHERAPY; STATISTICS; SURGERY; TRANSPLANTATION (SURGICAL); TUMORS; WALLS (STRUCTURAL PARTITIONS);

ADJUVANT RADIOTHERAPY; ADULT PATIENTS; ELSEVIER (CO); GROUP STUDIES; HAZARD RATIO (HR); LOCAL CONTROL (LC); LOCAL RECURRENCE; MALIGNANT TUMORS; RISK FACTORS; SCANDINAVIA; SOFT TISSUE SARCOMA (STS);

TISSUE;

ADJUVANT THERAPY; ADOLESCENT; ADULT; AGED; ARTICLE; CANCER CONTROL; CANCER GRADING; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SURGERY; CONTROLLED STUDY; FEMALE; FOLLOW UP; HUMAN; LIMB; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK FACTOR; SOFT TISSUE SARCOMA; TRUNK; TUMOR LOCALIZATION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; EXTREMITIES; FEMALE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NORWAY; RADIOTHERAPY, ADJUVANT; RETROSPECTIVE STUDIES; SARCOMA; SWEDEN; THORAX; TREATMENT OUTCOME;

EID: 44349142848     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2007.11.023     Document Type: Article

References (45)

1. Gustafson P. Soft tissue sarcoma: Epidemiology and prognosis in 508 patients. Acta Orthop Scand Suppl 259 (1994) 1-31
2. Vraa S., Keller J., Nielsen O.S., et al. Prognostic factors in soft tissue sarcomas: the Aarhus experience. Eur J Cancer 34 (1998) 1876-1882
3. Eilber F.C., Rosen G., Nelson S.D., et al. High-grade extremity soft tissue sarcomas: Factors predictive of local recurrence and its effect on morbidity and mortality. Ann Surg 237 (2003) 218-226
4. Zagars G.K., Ballo M.T., Pisters P.W., et al. Prognostic factors for patients with localized soft-tissue sarcoma treated with conservation surgery and radiation therapy: An analysis of 225 patients. Cancer 97 (2003) 2530-2543
5. Strander H., Turesson I., and Cavallin-Stahl E. A systematic overview of radiation therapy effects in soft tissue sarcomas. Acta Oncol 42 (2003) 516-531
6. Trovik C.S. Local recurrence of soft tissue sarcoma: A Scandinavian Sarcoma Group project. Acta Orthop Scand Suppl 72 (2001) 1-31
7. Pisters P.W., O'Sullivan B., and Maki R.G. Evidence-based recommendations for local therapy for soft tissue sarcomas. J Clin Oncol 25 (2007) 1003-1008
8. Pisters P.W., Harrison L.B., Woodruff J.M., et al. A prospective randomized trial of adjuvant brachytherapy in the management of low-grade soft tissue sarcomas of the extremity and superficial trunk. J Clin Oncol 12 (1994) 1150-1155
9. Yang J.C., Chang A.E., Baker A.R., et al. Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity. J Clin Oncol 16 (1998) 197-203
10. Keus R.B., Rutgers E.J., Ho G.H., et al. Limb-sparing therapy of extremity soft tissue sarcomas: Treatment outcome and long-term functional results. Eur J Cancer 30A (1994) 1459-1463
11. Wilson A.N., Davis A., Bell R.S., et al. Local control of soft tissue sarcoma of the extremity: The experience of a multidisciplinary sarcoma group with definitive surgery and radiotherapy. Eur J Cancer 30A (1994) 746-751
12. Alektiar K.M., Velasco J., Zelefsky M.J., et al. Adjuvant radiotherapy for margin-positive high-grade soft tissue sarcoma of the extremity. Int J Radiat Oncol Biol Phys 48 (2000) 1051-1058
13. Rosenberg S.A., Tepper J., Glatstein E., et al. The treatment of soft-tissue sarcomas of the extremities: Prospective randomized evaluations of (1) limb-sparing surgery plus radiation therapy compared with amputation and (2) the role of adjuvant chemotherapy. Ann Surg 196 (1982) 305-315
14. Brennan M.F., Hilaris B., Shiu M.H., et al. Local recurrence in adult soft-tissue sarcoma: A randomized trial of brachytherapy. Arch Surg 122 (1987) 1289-1293
15. Trovik C.S., Bauer H.C., Berlin O., et al. Local recurrence of deep-seated, high-grade, soft tissue sarcoma: 459 patients from the Scandinavian Sarcoma Group Register. Acta Orthop Scand 72 (2001) 160-166
16. Stotter A.T., A'Hern R.P., Fisher C., et al. The influence of local recurrence of extremity soft tissue sarcoma on metastasis and survival. Cancer 65 (1990) 1119-1129
17. Pisters P.W., Harrison L.B., Leung D.H., et al. Long-term results of a prospective randomized trial of adjuvant brachytherapy in soft tissue sarcoma. J Clin Oncol 14 (1996) 859-868
18. Mollabashy A., Virkus W.W., Zlotecki R.A., et al. Radiation therapy for low-grade soft tissue sarcoma. Clin Orthop Relat Res (2002) 190-195
19. Scandinavian Sarcoma Group Homepage. Available from: www.ssg-org.net.
20. Schwartz D.L., Einck J., Hunt K., et al. The effect of delayed postoperative irradiation on local control of soft tissue sarcomas of the extremity and torso. Int J Radiat Oncol Biol Phys 52 (2002) 1352-1359
21. Bauer H.C., Trovik C.S., Alvegard T.A., et al. Monitoring referral and treatment in soft tissue sarcoma: Study based on 1,851 patients from the Scandinavian Sarcoma Group Register. Acta Orthop Scand 72 (2001) 150-159
22. Angervall L., and Kindblom L.G. Principles for pathologic-anatomic diagnosis and classification of soft-tissue sarcomas. Clin Orthop Relat Res (1993) 9-18
23. Noria S., Davis A., Kandel R., et al. Residual disease following unplanned excision of soft-tissue sarcoma of an extremity. J Bone Joint Surg Am 78 (1996) 650-655
24. Siebenrock K.A., Hertel R., and Ganz R. Unexpected resection of soft-tissue sarcoma: More mutilating surgery, higher local recurrence rates, and obscure prognosis as consequences of improper surgery. Arch Orthop Trauma Surg 120 (2000) 65-69
25. Goodlad J.R., Fletcher C.D., and Smith M.A. Surgical resection of primary soft-tissue sarcoma: Incidence of residual tumour in 95 patients needing re-excision after local resection. J Bone Joint Surg Br 78 (1996) 658-661
26. Meis-Kindblom J.M., Bjerkehage B., Bohling T., et al. Morphologic review of 1000 soft tissue sarcomas from the Scandinavian Sarcoma Group (SSG) Register: The peer-review committee experience. Acta Orthop Scand Suppl 285 (1999) 18-26
27. Enneking W.F., Spanier S.S., and Goodman M.A. A system for the surgical staging of musculoskeletal sarcoma. Clin Orthop Relat Res (1980) 106-120
28. Rydholm A., and Rooser B. Surgical margins for soft-tissue sarcoma. J Bone Joint Surg Am 69 (1987) 1074-1078
29. Alvegard T. Management and prognosis of patients with high-grade soft tissue sarcomas: An evaluation of a Scandinavian Joint Care program. Thesis, University of Lund, Sweden, 1989. p. 1-40.
30. Collin C., Hajdu S.I., Godbold J., et al. Localized operable soft tissue sarcoma of the upper extremity: Presentation, management, and factors affecting local recurrence in 108 patients. Ann Surg 205 (1987) 331-339
31. Engellau J., Bendahl P.O., Persson A., et al. Improved prognostication in soft tissue sarcoma: Independent information from vascular invasion, necrosis, growth pattern, and immunostaining using whole-tumor sections and tissue microarrays. Hum Pathol 36 (2005) 994-1002
32. Choong P.F., Petersen I.A., Nascimento A.G., et al. Is radiotherapy important for low-grade soft tissue sarcoma of the extremity?. Clin Orthop Relat Res (2001) 191-199
33. O'Sullivan B., Davis A.M., Turcotte R., et al. Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: A randomised trial. Lancet 359 (2002) 2235-2241
34. Alho A., Alvegard T.A., Berlin O., et al. Surgical margin in soft tissue sarcoma: The Scandinavian Sarcoma Group experience. Acta Orthop Scand 60 (1989) 687-692
35. Rydholm A., Gustafson P., Rooser B., et al. Limb-sparing surgery without radiotherapy based on anatomic location of soft tissue sarcoma. J Clin Oncol 9 (1991) 1757-1765
36. Rydholm A., Gustafson P., Rooser B., et al. Subcutaneous sarcoma: A population-based study of 129 patients. J Bone Joint Surg Br 73 (1991) 662-667
37. Alektiar K.M., Leung D., Zelefsky M.J., et al. Adjuvant radiation for stage II-B soft tissue sarcoma of the extremity. J Clin Oncol 20 (2002) 1643-1650
38. Baldini E.H., Goldberg J., Jenner C., et al. Long-term outcomes after function-sparing surgery without radiotherapy for soft tissue sarcoma of the extremities and trunk. J Clin Oncol 17 (1999) 3252-3259
39. Geer R.J., Woodruff J., Casper E.S., et al. Management of small soft-tissue sarcoma of the extremity in adults. Arch Surg 127 (1992) 1285-1289
40. Pisters P.W., Pollock R.E., Lewis V.O., et al. Long-term results of prospective trial of surgery alone with selective use of radiation for patients with T1 extremity and trunk soft tissue sarcomas. Ann Surg 246 (2007) 675-682
41. Pisters P.W. Combined modality treatment of extremity soft tissue sarcomas. Ann Surg Oncol 5 (1998) 464-472
42. O'Sullivan B., Ward I., and Catton C. Recent advances in radiotherapy for soft-tissue sarcoma. Curr Oncol Rep 5 (2003) 274-281
43. Buchholz T.A., Austin-Seymour M.M., Moe R.E., et al. Effect of delay in radiation in the combined modality treatment of breast cancer. Int J Radiat Oncol Biol Phys 26 (1993) 23-35
44. Byers R.M., Clayman G.L., Guillamondequi O.M., et al. Resection of advanced cervical metastasis prior to definitive radiotherapy for primary squamous carcinomas of the upper aerodigestive tract. Head Neck 14 (1992) 133-138
45. Gustafson P., Rooser B., and Rydholm A. Is local recurrence of minor importance for metastases in soft tissue sarcoma?. Cancer 67 (1991) 2083-2086