PEDF promotes biosynthesis of a novel anti-inflammatory and anti-apoptotic mediator NPD1 in retinal pigment epithelial cells

Ochsner Journal

Volumn 8, Issue 1, 2008, Pages 39-43

  Reinoso, Maria A ^a,b   Mukherjee, Pranab ^c   Marcheselli, Victor ^c   Bergsma, Donald ^b   Hesse, Richard ^a   Bazan, Nicolas ^b,c  

^a OCHSNER CLINIC FOUNDATION   (United States)

^b LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Neuroprotectin D1; Neuroprotection; Retinal pigmentary epithelium

Indexed keywords

ANTIINFLAMMATORY AGENT; DOCOSAHEXAENOIC ACID; NEUROPROTECTIN D1; PIGMENT EPITHELIUM DERIVED FACTOR; PROTEIN BCL XL;

ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG MECHANISM; DRUG SYNTHESIS; GLAUCOMA; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NEUROPROTECTION; NUCLEOLUS; OXIDATIVE STRESS; PIGMENT EPITHELIUM; RETINA DEGENERATION; RETINA MACULA DEGENERATION;

EID: 44349140113     PISSN: 15245012     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Bazan NG. Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors. Trends Neurosci. 2006;29:263-271.
2. Houenou LJ, D'Costa AP, Li L, et al. Pigment epithelium-derived factor promotes the survival and differentiation of developing spinal motor neurons. J Comp Neurol. 1999;412:506-514.
3. Young RW, Bok D. Participation of the retinal pigment epithelium in the rod outer segment renewal process. J Cell Biol. 1969;42:392-403.
4. Bazan NG. Neuroprotectin D1 (NPD1): a DHA-derived mediator that protects brain and retina against cell injury-induced oxidative stress. Brain Pathol. 2005;15:159-166.
5. Bazan NG, Scott BL, Reddy TS, et al. Decreased content of docosahexaenoate and arachidonate in plasma phospholipids in Usher's syndrome. Biochem Biophys Res Commun. 1986;141:600-604.
6. Bazan NG. Homeostatic regulation of photoreceptor cell integrity: Significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid. Invest Ophthalmol Vis Sci. 2007;48:4866-4881.
7. Mukherjee PK, Marcheselli VL, de Rivero Vaccari JC, et al. Photoreceptor outer segment phagocytosis attenuates oxidative stress-induced apoptosis with concomitant neuroprotectin D1 synthesis. Proc Natl Acad Sci U S A. 2007;104:13158-13163.
8. Klein JA, Ackerman SL. Oxidative stress, cell cycle, and neurodegeneration. J Clin Invest. 2003;111:785-793.
9. Mukherjee PK, Marcheselli VL, Serhan CN, et al. Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. Proc Natl Acad Sci U S A. 2004;101:8491-8496.
10. Gross A, McDonnell JM, Korsmeyer SJ. BCL-2 family members and the mitochondria in apoptosis. Genes Dev. 1999;13:1899-1911.
11. Dawson DW, Volpert OV, Gillis P, et al. Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science. 1999;285:245-248.
12. Mukherjee PK, Marcheselli VL, Barreiro S, et al. Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling. Proc Natl Acad Sci U S A. 2007;104:13152-13157.
13. Lukiw WJ, Cui JG, Marcheselli VL, et al. A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease. J Clin Invest. 2005;115:2774-2783.