Isoenzymes A and B of N-acetyl-β-D-hexosaminidase in serum and urine of patients with pancreatic cancer

Hepato-Gastroenterology

Volumn 55, Issue 82-83, 2008, Pages 695-698

  Szajda, Slawomir Dariusz ^a   Snarska, Jadwiga ^a   Jankowska, Anna ^a   Puchalski, Zbigniew ^a   Zwierz, Krzysztof ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

N acetylhexosaminidase isoenzymes; Pancreatic cancer; Tumor markers

Indexed keywords

BETA N ACETYLHEXOSAMINIDASE A; BETA N ACETYLHEXOSAMINIDASE B; BIURET;

ADULT; AGED; ARTICLE; CALORIMETRY; CANCER PATIENT; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME BLOOD LEVEL; FEMALE; HUMAN; MALE; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; URINALYSIS;

ADENOCARCINOMA; ADULT; AGED; FEMALE; HEXOSAMINIDASE A; HEXOSAMINIDASE B; HUMANS; MALE; MIDDLE AGED; PANCREATIC NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 44349138142     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P: Molecular biology of the cell. NY; Garland Science, 2002; pp. 1313-1362.
2. Borzym-Kluczyk M, Darewicz B, Knas M, Szajda SD, Sulik M, Olszewska E, Zwierz K: The activity of N-acetyl-β-glucosaminidase and its isoenzymes in the renal tissue, serum and urine of patients with renal cancer. Contemporary Oncology 2005; 9(7):287-290.
3. Zwierz K, Gindzieński A, Głowacka D, Porowski T: The degradation of glycoconjugates in the human gastric mucous membrane. Acta Med Hung 1981; 38:145-152.
4. Zwierz K, Zalewska A, Zoch-Zwierz W: Isoenzymes of N-acetyl-beta-hexosaminidase. Acta Biochim Polon 1999; 46(3):739-751.
5. Pezer LF, Tutor JC: Assay of beta-N-acetylhexosaminidase isoenzymes in different biological specimens by means of differentiation of their activation energies. Clin Chem 1998; 44:226-231.
6. Geiger B, Arnon R: Chemical characterization and subunit structure of human N-acetylhexosaminidases A and B. Biochemistry 1976; 15(16):3484-3493.
7. Suzuki K, Sango K, Proia RL, Langaman C: Mice deficient in all forms of lysosomal beta-hexosaminidase show mucopolysaccharidosis-like pathology. J Neuropathol Exp Neurol 1997; 56(6):693-703.
8. Jaeken J, Carchon H: The carbohydrate-deficient glycoprotein syndromes: an overview. J Inherit Metab Dis 1993; 16:813-820.
9. Popko J, Zalewska A, Gołaszewska Z, Marciniak J, Sierakowski S, Worowski K, Zwierz K: Comparative analysis of hexosaminidase and cathepsin D expression in synovial fluid of patients with rheumatoid arthritis and traumatized joints. Clin Exper Rheumatol 2005; 23(5):725-726.
10. Goren MP, Wright RK, Horowitz ME, Crom WR, Meyer WH: Urinary N-acetyl-β-D-glucosaminidase and serum creatinine concentrations predict impaired excretion of methotrexate. J Clin Oncol 1987; 5:804-810.
11. Szajda SD, Snarska J, Kamiński F, Siedlecka K, Waszkiewicz N, Knaś M, Zwierz K: The activity of N-acetyl-β-D-hexosaminidase in serum and urine of patients with pancreatic cancer. Contemporary Oncology 2006; 3:92-95.
12. Duffy MJ: Clinical uses of tumor markers: a critical review. Crit Rev Clin Lab Sci 2001; 38:225-262.
13. Lygidakis NJ, Jain S, Sacchi M, Vrachnos P: Adenocarcinoma of the pancreas-past, present and future. Hepatogastroenterology 2005; 52:1281-1292.
14. Marciniak J, Zalewska A, Popko J, Zwierz K: Optimization of an enzymes method for the determination of lysosomal N-acetyl-β-D- hexosaminidase and β-glucuronidase in synovial fluid. Clin Chem Lab Med 2006; 44(8):933-937.
15. Dawson RMC, Elliott WH, Jones KM: Data of Biochemical Research. 2nd Edition. New York and Oxford: Oxford University Press, 1969; pp.618.
16. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with Folin phenol reagent, J Biol Chem 1951; 193:265-275.
17. Winchester B: Lysosomal metabolism of glycoproteins. Glycobiology 2005; 15(6):IR-15R.
18. Ostrowska L, Zwierz K, Koniusz Z, Gindzienski A: Function, properties and clinical significance of N-acetyl-beta-D-hexosaminidase. Post Hig Med Dośw 1993; 47:67-79.
19. Kärkkäinen P, Poikolainen K, Salaspuro M: Serum 8-hexosaminidase as a marker of heavy drinking alcohol. Clin ExperRes 1990; 14(2):187-190.
20. Pott G, Schneider M, van Husen N, von Bassewitz DB, Eberhardt G, Gerlach U: Alpha 1-Antitrypsin phenotypes in patients with chronic liver diseases. Z Gastroenterol 1983; 21(7):318-323.
21. Chew SL, Lins RL, Daelemans R, Nuyts GD, De Broe ME: Urinary enzymes in acute renal failure. Nephrol Dial Transplant 1993; 8:507-511.
22. Costigan MG, Rustom R, Bone JM, Shenkin A: Origin and significance of urine N-acetyl-beta-D-glucosaminidase (NAG) in renal patients with proteinuria. Clin Chim Acta 1996; 133:133-144.