Practical asymmetric synthesis of a novel γ-secretase inhibitor

Tetrahedron

Volumn 64, Issue 27, 2008, Pages 6440-6443

  Wang, Zheng ^a   Resnick, Lynn ^a  

^a PFIZER INC   (United States)

Author keywords

Secretase inhibitor; Chiral Strecker; Davis' sulfonimine; Evans' oxazolidinone

Indexed keywords

2 AMINO 5,5,5 TRIFLUORO 3 METHYLPENTANOIC ACID HYDROCHLORIDE; 4 BENZYL 3 (4,4,4 TRIFLUOROBUTANOYL) 1,3 OXAZOLIDIN 2 ONE; 4,4,4 TRIFLUORO 2 METHYL BUTAN 1 OL; 4,4,4 TRIFLUORO 2 METHYL BUTANAL; 5 CHLORO N [4,4,4 TRIFLUORO 1 (HYDROXYMETHYL) 2 METHYLBUTYL]THIOPENE 2 SULFONAMIDE; ACETIC ACID ETHYL ESTER; AMINO ACID; AMINOALCOHOL; BUTYRALDEHYDE; GAMMA SECRETASE INHIBITOR; HEPTANE; HYDROXYL THIOPHENE SULFONAMIDE; IMINE; N [1 CYANO 4,4,4 TRIFLUORO 2 METHYLBUTYL] 4 METHYLBENZENESULFINAMIDE; N [METHYL 4,4,4 TRIFLUOROBUTYLIDENE] 4 TOLUENESULFINAMIDE; OXAZOLIDINONE DERIVATIVE; SULFINAMIDE; SULFONAMIDE; SULFONIMINE;

ARTICLE; CHIRALITY; DRUG OXIDATION; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METHYLATION; PRIORITY JOURNAL; STEREOCHEMISTRY;

EID: 44349135597     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2008.04.072     Document Type: Article

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