Ethanol and pain sensitivity: Effects in healthy subjects using an acute pain paradigm

Alcoholism: Clinical and Experimental Research

Volumn 32, Issue 6, 2008, Pages 952-958

  Perrino Jr , Albert C ^a   Ralevski, Elizabeth ^a,b   Acampora, Gregory ^a,b   Edgecombe, Javon ^a,b   Limoncelli, Diana ^a,b   Petrakis, Ismene L ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

Author keywords

Alcoholism; Analgesia; Ethanol; Family History; Pain; Vulnerability

Indexed keywords

ALCOHOL; PLACEBO;

ADULT; ALCOHOLISM; ANALGESIC ACTIVITY; ARTICLE; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; ELECTROSTIMULATION; FAMILY HISTORY; FEMALE; HUMAN; INFUSION PUMP; MALE; NOCICEPTION; NOCICEPTIVE STIMULATION; NORMAL HUMAN; OUTCOME ASSESSMENT; PAIN ASSESSMENT; PAIN THRESHOLD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SENSITIVITY ANALYSIS; STEADY STATE; VISUAL ANALOG SCALE;

ADULT; ALCOHOLISM; ANALGESIA; ANALGESICS; BREATH TESTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ETHANOL; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; PAIN; PAIN THRESHOLD; PLACEBOS;

EID: 44349127238     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2008.00653.x     Document Type: Article

References (33)

1. Angst MS, Ramaswamy B, Davies MF, Maze M (2004) Comparative analgesic and mental effects of increasing plasma concentrations of dexmedetomidine and alfentanil in humans. Anesthesiology 101 : 744 752.
2. Brown RA, Cutter HS (1977) Alcohol, customary drinking behavior, and pain. J Abnorm Psychol 86 : 179 188.
3. Buck KJ (1996) Molecular genetic analysis of the role of GABAergic systems in the behavioral and cellular actions of alcohol. Behav Genet 26 : 313 323.
4. Chizh BA (2002) Novel approaches to targeting glutamate receptors for the treatment of chronic pain: review article. Amino Acids 23 : 169 176.
5. Dahan A, Yassen A, Romberg R, Sarton E, Teppema L, Olofsen E, Danhof M (2006) Buprenorphine induces ceiling in respiratory depression but not in analgesia. Br J Anaesth 96 : 627 632.
6. Finn PR, Pihl RO (1987) Men at high risk for alcoholism: the effect of alcohol on cardiovascular response to unavoidable shock. J Abnorm Psychol 96 : 230 236.
7. Finn PR, Pihl RO (1988) Risk for alcoholism: a comparison between two different groups of sons of alcoholics on cardiovascular reactivity and sensitivity to alcohol. Alcohol Clin Exp Res 12 : 742 747.
8. Fisher K, Coderre TJ, Hagen NA (2000) Targeting the N-methyl-D-aspartate receptor for chronic pain management. Preclinical animal studies, recent clinical experience and future research directions. J Pain Symptom Manage 20 : 358 373.
9. Harris R, Mihic S, Valenzuela C (1998) Alcohol and benzodiazepines: recent mechanistic studies. Drug Alcohol Depend 51 : 155 164.
10. Hartmannsgruber MW, Swamidoss CP, Budde A, Qadir S, Brull SJ, Silverman DG (1999) A method for overcoming the ceiling effect of bounded pain scales. J Clin Monit Comput 15 : 455 459.
11. James MF, Duthie AM, Duffy BL, McKeag AM, Rice CP (1978) Analgesic effect of ethyl alcohol. Br J Anaesth 50 : 139 141.
12. Kumar S, Fleming RL, Morrow AL (2004) Ethanol regulation of gamma- aminobutyric acid A receptors: genomic and nongenomic mechanisms. Pharmacol Ther 101 : 211 226.
13. Lovinger DM, Crabbe JC (2005) Laboratory models of alcoholism: treatment target identification and insight into mechanisms. Nat Neurosci 8 : 1471 1480.
14. MATLAB (1987) Mac II-MATLAB. The Mathworks, Inc., South Natick, MA.
15. Meller ST, Dykstra C, Pechman PS, Maves TJ, Gebhart GF (1993) Ethanol dose-dependently attenuates NMDA-mediated thermal hyperalgesia in the rat. Neurosci Lett 154 : 137 140.
16. Mullin F, Luckhardt AB (1934) The effect of alcohol on cutaneous tactile and pain sensitivity. Am J Physiol 109 : 77 78.
17. Noble E (1996) Alcoholism and the dopaminergic system: a review. Addict Biol 1 : 222 248.
18. O'Connor S, Morzorati S, Christian J, Li TK (1998) Clamping breath alcohol concentration reduces experimental variance: application to the study of acute tolerance to alcohol and alcohol elimination rate. Alcohol Clin Exp Res 22 : 202 210.
19. O'Connor S, Ramchandani VA, Li TK (2000) PBPK modeling as a basis for achieving a steady BrAC of 60+/- 5 mg% within ten minutes. Alcohol Clin Exp Res 24 : 426 427.
20. Petrakis IL, Limoncelli D, Gueorguieva R, Jatlow P, Boutros NN, Trevisan L, Gelernter J, Krystal JH (2004) Altered NMDA glutamate receptor antagonist response in individuals with a family vulnerability to alcoholism. [See comment]. Am J Psychiatry 161 : 1776 1782.
21. Petrenko AB, Yamakura T, Baba H, Shimoji K (2003) The role of N-methyl-D-aspartate (NMDA) receptors in pain: a review. Anesth Analg 97 : 1108 1116.
22. Petrie A (1978) Individuality in Pain and Suffering. Chicago Press, Chicago, IL.
23. Pihl RO, Finn PR, Peterson JB (1989) Autonomic hyper-reactivity and risk for alcoholism. Prog Neuro-Psychopharmacol Biol Psychiatry 13 : 489 496.
24. Pollock VE (1992) Meta-analysis of subjective sensitivity to alcohol in sons of alcoholics. [See comment]. Am J Psychiatry 149 : 1534 1538.
25. Pud D, Yarnitsky D, Sprecher E, Rogowski Z, Adler R, Eisenberg E (2006) Can personality traits and gender predict the response to morphine? An experimental cold pain study. EJP 10 : 103 112.
26. Ramchandani VA, Bolane J, Li TK, O'Connor S (1999) A physiologically- based pharmacokinetic (PBPK) model for alcohol facilitates rapid BrAC clamping. Alcohol Clin Exp Res 23 : 617 623.
27. Schuckit MA (1994) Low level of response to alcohol as a predictor of future alcoholism. Am J Psychiatry 151 : 184 189.
28. Stewart SH, Finn PR, Pihl RO (1995) A dose-response study of the effects of alcohol on the perceptions of pain and discomfort due to electric shock in men at high familial-genetic risk for alcoholism. Psychopharmacology 119 : 261 267.
29. Stewart SH, Pihl RO (1994) The effects of alcohol administration on psychophysiological and subjective-emotional responses to aversive stimulation in anxiety sensitive women. Psychol Addict Behav 8 : 29 42.
30. Subramanian M, Heil S, Kruger M, Collins K, Buck P, Zawacki T, Abbey A, Sokol R, Diamond M (2002) A three-stage alcohol clamp procedure in human subjects. Alcohol Clin Exp Res 26 : 1479 1483.
31. Wolff HG, Hardy JD, Goodell H (1941) Measurement of the effect on the pain threshold of acetylsalicylic acid, acetanilid, acetophenetidin, aminopyrine, ethyl alcohol, trichlorethylene, a barbiturate, quinne, ergotamine tartrate and caffeine: an analysis of their relation to the pain experience. J Clin Invest 20 : 63 80.
32. Wolff HG, Hardy JD, Goodell H (1942) Studies on pain: measurement of the effect of ethyl alcohol on the pain threshold and on the "alarm" reaction. J Pharmacol 75 : 38 49.
33. Woodrow KM, Eltherington LG (1988) Feeling no pain: alcohol as an analgesic. [Erratum appears in pain 1991 Sep;46(3):343]. Pain 32 : 159 163.