Polyaspartoyl·l-arginine inhibits platelet aggregation through stimulation of NO release from endothelial cells

European Journal of Pharmacology

Volumn 588, Issue 1, 2008, Pages 41-46

  Tang, Zhiyu ^a   Zhao, Ming ^b   Li, Changling ^a   Wang, Yinye ^a   Peng, Shiqi ^b  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Argininosuccinate synthetase; Citrulline NO cycle; l arginine; Nitric oxide; Platelet aggregation; Polyaspartoyl l arginine; Rat aortic endothelial cell

Indexed keywords

AMINO ACID; ARGININE DERIVATIVE; ARGININOSUCCINATE SYNTHASE; ASPARTIC ACID; CITRULLINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; POLYASPARTOYL AGININE; SUCCINIC ACID; ANTITHROMBOCYTIC AGENT; ARGININE; ENZYME INHIBITOR; NITRIC OXIDE; PEPTIDE; POLYASPARTOYL L ARGININE; POLYASPARTOYL-L-ARGININE;

ANIMAL CELL; ANIMAL TISSUE; ANTICOAGULATION; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RAT AORTIC ENDOTHELIAL CELL; THROMBOCYTE AGGREGATION; ANIMAL; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; MALE; METABOLISM; SPRAGUE DAWLEY RAT; THORACIC AORTA; WESTERN BLOTTING;

AMINO ACIDS; ANIMALS; AORTA, THORACIC; ARGININE; ARGININOSUCCINATE SYNTHASE; BLOTTING, WESTERN; ENDOTHELIAL CELLS; ENZYME INHIBITORS; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PEPTIDES; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 44349126591     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.04.012     Document Type: Article

References (38)

1. Ahlers B.A., Parnell M.M., Chin-Dusting J.P., and Kaye D.M. An age-related decline in endothelial function is not associated with alterations in l-arginine transport in humans. J. Hypertens. 22 (2004) 321-327
2. Anfossi G., Russo I., Massucco P., Mattiello L., Perna P., Tassone F., and Trovati M. l-Arginine modulates aggregation and intracellular cyclic 39,59-guanosine monophosphate levels in human platelets: direct effect and interplay with antioxidative thiol agent. Thromb. Res. 94 (1999) 307-316
3. Az-ma T., Hardian., and Yuge O. Inhibitory effect of lidocaine on cultured porcine aortic endothelial cell-dependent antiaggregation of platelets. Anesthesiology 83 (1995) 374-381
4. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
5. Brune B., and Hanstein K. Rapid reversibility of nitric oxide induced platelet inhibition. Thromb. Res. 90 (1998) 83-91
6. Centra M., Ratych R.E., Cao G.L., Li J., Williams E., Taylor R.M., and Rosen G.M. Culture of bovine pulmonary artery endothelial cells on Gelfoam blocks. FASEB J. 6 (1992) 3117-3121
7. Cheung P.Y., Salas E., Etches P.C., Phillipos E., Schulz R., and Radomski M.W. Inhaled nitric oxide and inhibition of platelet aggregation in critically ill neonates. Lancet 351 (1998) 1181-1182
8. Contreras R., Fuentes O., Mann G.E., and Sobrevia L. Diabetes and insulin-induced stimulation of l-arginine transport and nitric oxide synthesis in rabbit isolated gastric glands. J. Physiol. 498 (1997) 787-796
9. Dambisya Y.M., and Lee T.L. A thromboelastography study on the in vitro effects of l-arginine and l-NG-nitro arginine methyl ester on human whole blood coagulation and fibrinolysis. Blood Coagul. Fibrinolysis. 7 (1996) 678-683
10. Fitzgerald D.J., Roy L., Catella F., and FitzGerald G.A. Platelet activation in unstable coronary disease. N. Engl. J. Med. 315 (1986) 983-989
11. Flam B.R., Hartmann P.J., Harrell-Booth M., Solomonson L.P., and Eichler D.C. Caveolar localization of arginine regeneration enzymes, argininosuccinate synthase, and lyase, with endothelial nitric oxide synthase. Nitric Oxide 5 (2001) 187-197
12. Furchgott R.F., and Zawadzki J.V. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288 (1980) 373-376
13. Goumas G., Tentolouris C., Tousoulis D., Stefanadis C., and Toutouzas P. Therapeutic modification of the l-arginine-eNOS pathway in cardiovascular diseases. Atherosclerosis 154 (2001) 255-267
14. Hattori Y., Campbell E.B., and Gross S.S. Argininosuccinate synthetase mRNA and activity are induced by immunostimulants in vascular smooth muscle. Role in the regeneration or arginine for nitric oxide synthesis. J. Biol. Chem. 269 (1994) 9405-9408
15. Hecker M., Sessa W.C., Harris H.J., Anggard E.E., and Vane J.R. The metabolism of l-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle l-citrulline to l-arginine. Proc. Natl. Acad. Sci. U. S. A. 87 (1990) 8612-8616
16. Husson A., Brasse-Lagnel C., Fairand A., Renouf S., and Lavoinne A. Argininosuccinate synthetase from the urea cycle to the citrulline-NO cycle. Eur. J. Biochem. 270 (2003) 1887-1899
17. Igawa T., Tani T., Chijiwa T., Shiragiku T., Shimidzu S., Kawamura K., Kato S., Unemi F., and Kimura Y. Potentiation of anti-platelet aggregating activity of cilostazol with vascular endothelial cells. Thromb. Res. 57 (1990) 617-623
18. Ignarro L.J., Buga G.M., Wood K.S., Byrns R.E., and Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl. Acad. Sci. U. S. A. 84 (1987) 9265-9269
19. Jaffe E.A., Hoyer L.W., and Nachman R.L. Synthesis of antihemophilic factor antigen by cultured human endothelial cells. J. Clin. Invest. 52 (1973) 2757-2764
20. Kanno K., Hirata Y., Emori T., Ohta K., Eguchi S., Imai T., and Marumo F. l-arginine infusion induces hypotension and diuresis/natriuresis concomitant with increased urinary excretion of nitrite/nitrate and cyclic GMP in humans. Clin. Exp. Pharmacol. Physiol. 19 (1992) 619-625
21. Kurata M., Tanaka K., and Usami M. Different roles of endothelium-derived substances on inhibiting platelet aggregation in whole blood. Gen. Pharmacol. 28 (1997) 671-673
22. Macdonald P.S., Read M.A., and Dusting G.J. Synergistic inhibition of platelet aggregation by endothelium-derived relaxing factor and prostacyclin. Thromb. Res. 49 (1988) 437-449
23. Marietta M., Facchinetti F., Neri I., and Piccinini F. l-arginine infusion decreases platelet aggregation through an introplatelet nitric oxide release. Thromb. Res. 88 (1997) 229-235
24. Mellgren K., Mellgren G., Lundin S., Wennmalm A., and Wadenvik H. Effect of nitric oxide gas on platelets during open heart operations. Ann. Thorac. Surg. 65 (1998) 1335-1341
25. Mikashima H., Takehara S., Muramoto Y., Khomaru T., Terasawa M., Tahara T., and Maruyama Y. An antagonistic activity of etizolam on platelet-activating factor (PAF). In vitro effects on platelet aggregation and PAF receptor binding. Jpn. J. Pharmacol. 44 (1987) 387-391
26. Misko T.P., Schilling R.J., Salvemini D., Moore W.M., and Currie M.G. A fluorometric assay for the measurement of nitrite in biological samples. Anal. Biochem. 214 (1993) 11-16
27. Radomski M.W., Palmer R.M., and Moncada S. The anti-aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide. Br. J. Pharmacol. 92 (1987) 639-646
28. Radomski M.W., Palmer R.M., and Moncada S. Characterization of the l-arginine:nitric oxide pathway in human platelets, Br. J. Pharmacol. 101 (1990) 325-328
29. Radomski M.W., Vallance P., Whitley G., Foxwell N., and Moncada S. Platelet adhesion to human vascular endothelium is modulated by constitutive and cytokine induced nitric oxide. Cardiovasc. Res. 27 (1993) 1380-1382
30. Ratner S., and Petrack B. Biosynthesis of urea. III. Further studies on arginine synthesis from citrulline. J. Biol. Chem. 191 (1951) 693-705
31. Sobrevia L., Yudilevich D.L., and Mann G.E. Elevated d-glucose induces insulin insensitivity in human umbilical endothelial cells isolated from gestational diabetic pregnancies. J. Physiol. 506 (1998) 219-230
32. Su Y., and Block E.R. Hypoxia inhibits l-arginine synthesis from l-citrulline in porcine pulmonary artery endothelial cells. Am. J. Physiol. 269 (1995) L581-L587
33. Tang Z.Y., Wang Y., Xiao Y., Zhao M., and Peng S. Anti-thrombotic activity of PDR, a newly synthesized l-Arg derivative, on three thrombosis models in rats. Thromb. Res. 110 (2003) 127-133
34. Towbin H., Staehelin T., and Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. U. S. A. 76 (1979) 4350-4354
35. Visek W.J. Arginine needs, physiological state and usual diets. J. Nutr. 116 (1986) 36-46
36. Wang Y.Y., Tang Z.Y., Dong M., Liu X.Y., and Peng S.Q. Inhibition of platelet aggregation by polyaspartoyl l-arginine and its mechanism. Acta. Pharmacol. Sin. 25 (2004) 469-473
37. Wu G., and Meininger C.J. Regulation of l-arginine synthesis from l-citrulline by l-glutamine in endothelial cells. Am. J. Physiol. 265 (1993) H1965-H1971
38. Xie L., and Gross S.S. Argininosuccinate synthetase overexpression in vascular smooth muscle cells potentiates immunostimulant-induced NO production. J. Biol. Chem. 272 (1997) 16624-16630