L-arginine infusion decreases platelet aggregation through an intraplatelet nitric oxide release

Thrombosis Research

Volumn 88, Issue 2, 1997, Pages 229-235

  Marietta, M ^a,b   Facchinetti, F ^a   Neri, I ^a   Piccinini, F ^a   Volpe, A ^a   Torelli, G ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

L Arginine; L Arginine infusion; L Citrulline; Nitric oxide pathway; Platelet aggregation

Indexed keywords

ARGININE; CITRULLINE; CYCLIC GMP; NITRIC OXIDE;

AMINO ACID SEQUENCE; ANTICOAGULATION; ARTICLE; ENZYME ACTIVITY; ENZYME INHIBITION; HYPERCHOLESTEROLEMIA; HYPOTENSION; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION;

ADENOSINE DIPHOSPHATE; ADULT; ARGININE; BLOOD PRESSURE; CITRULLINE; COLLAGEN; DIASTOLE; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; NITRIC OXIDE; NITRITES; PLACEBOS; PLATELET AGGREGATION; SYSTOLE; TIME FACTORS;

EID: 0030659056     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(97)00233-8     Document Type: Article

References (16)

1. MELLION, B.T., IGNARRO, L.J., OHLSTEIN, E.H., PONTECORVO, E.G., HYMAN, A.L. and KADOWITZ, P.J. Evidence for the inhibitory role of adenosine 3′,5′-monophosphate in ADP-induced human aggregation in the presence of nitric oxide and related vasodilators. Blood 57, 946-955, 1981.
2. RADOMSKI, M.W., PALMER, R.M.J. and MONCADA, S. An L-Arginine/nitric oxide pathway present in the human platelets regulates aggregation. Proc Natl Acad Sci USA 87, 5193-5197, 1990.
3. RADOMSKI, M.W., PALMER, R.M.J. and MONCADA, S. Characterization of the L-Arginine:nitric oxide pathway in human platelets. Br J Pharmacol 101, 325-328, 1990.
4. MALINSKI, T., RADOMSKI, M.W., TAHA, Z. and MONCADA, S. Direct electrochemical measurement of nitric oxide released from human platelet. Biochem Biophys Res Commun 194, 960-965, 1993.
5. NAKAKI, T., HISHIKAWA, K., SUZUKI, H., SARUTA, T. and KATO, R. L-Arginine-induced hypotension (letter). Lancet 336, 696, 1990.
6. CREAGER, M.A., GALLAGHER, S.J., GIRERD, X.J., COLEMAN, S.M., DZAU, V.J. and COOKE JP. L-Arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans. J Clin Invest 90, 1248-1253 ,1992.
7. NERI, I., MAZZA, V., GALASSI, M.C., FACCHINETTI, F. and GENAZZANI, A.R. Effects of L-Arginine on utero-placental circulation in growth-retarded fetuses. Acta Obstet Gynecol Scand 75, 208-212, 1996.
8. TSAO, P.S., THEILMEIER, G., SINGER, A.H., LEUNG, L.L.K. and COOKE, J.P. L-Arginine attenuates platelet reactivity in hypercolesterolemic rabbits. Arterioscler Thromb 14, 1529-1533, 1994.
9. ADAMS, M.A., FORSYTH , C.J., JESSUP, W., ROBINSON, J. and CELERMAIER, D.S. Oral L- Arginine inhibits platelet aggregation but does not enhance endothelium-dependent dilatation in healthy young men. J Am Coll Cardiol 26, 1054-1061, 1995.
10. BORN, G.V.R. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature 194, 927-929, 1962.
11. FACCHINETTI, F., MARIETTA, M., NERI, I., TORELLI, G. and VOLPE, A. L-Arginine displays antithrombotic effects through nitric oxide release in pregnant women. Am J Obst Gynecol 176, S 169 (abstract), 1997.
12. RADOMSKI, M.W., PALMER, R.M.J. and MONCADA, S. Endogenous nitric oxide inhibits human platelet adhesion to vascolar endothelium. Lancet 8587, 1057-1058, 1989.
13. STAMLER, J.S., MENDELSOHN, M.E., AMARANTE, P., SMICK, D., ANDON, N., DAVIES, P.F., COOKE, J.P. and LOSCALZO, J. N-acetylcysteine potentiates platelet inhibition by endothelium-derived relaxing factor. Circ Res 65, 789-795, 1989.
14. JOHNSTONE, M.T., LAM, J.Y., LACOSTE, L., BARIBEAU, J., THEROUX, P. and WATERS, D. Methylene blue inhibits the antithrombotic effect of nitroglycerin. J Am Coll Cardiol 21, 255-259, 1993.
15. BOCCARDO, P., SOREGAROLI, M., AIELLO, S., NORIS, M., DONADELLI, R., LOJACONO, A., and BENIGNI, A. Systemic and fetal-maternal nitric oxide synthesis in normal pregnancy and pre-eclampsia. Br J Obst Gynaecol 103, 879-886, 1996.
16. SMULDERS, R.A., AARSEN, M., TERRLINK, T., DE VRIES, P.M.J., VAN KAMP, G.J., DONKER, A.J., STEHOUWER, C.D. Haemodynamic and biochemical responses to L-Arginine and L-Lysine infusions in normal subjects: L-Arginine-induced vasodilatation cannot be explained by non-specific effects of cationic amino acids. Clin Sci 92, 367-374, 1997.