Comparative effects of three 1,4-dihydropyridine derivatives [OSI-1210, OSI-1211 (etaftoron), and OSI-3802] on rat liver mitochondrial bioenergetics and on the physical properties of membrane lipid bilayers: Relevance to the length of the alkoxyl chain in positions 3 and 5 of the DHP ring

Chemico-Biological Interactions

Volumn 173, Issue 3, 2008, Pages 195-204

  Fernandes, Maria A S ^a   Pereira, Susana P S ^b   Jurado, Amália S ^b   Custódio, José B A ^b   Santos, Maria S ^b   Moreno, António J M ^a   Duburs, Gunars ^c   Vicente, Joaquim A F ^a  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c LATVIAN INSTITUTE OF ORGANIC SYNTHESIS   (Latvia)

Author keywords

1,4 Dihydropyridine derivatives; Liver mitochondria; Mitochondrial bioenergetics

Indexed keywords

CEREBROCRAST; DIHYDROPYRIDINE DERIVATIVE; DIMYRISTOYLPHOSPHATIDYLCHOLINE; ETAFTORON; MEMBRANE LIPID; OSI 1210; OSI 1211; OSI 3802;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOENERGY; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; ENTHALPY; LIVER MITOCHONDRION; MALE; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRIAL MEMBRANE; NONHUMAN; PHASE TRANSITION; PHOSPHORYLATION; RAT; RESPIRATION CONTROL; TOXICOLOGY; TRANSITION TEMPERATURE;

RATTUS;

EID: 44349090863     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2008.03.001     Document Type: Article

References (28)

1. Triggle D.J. The 1,4-dihydropyridine nucleus: a pharmacophoric template. Part 1. Actions at ion channels. Mini Rev. Med. Chem. 3 (2003) 215-223
2. Mason R.P., Marche P., and Hintze T.H. Novel vascular biology of third-generation L-type calcium channel antagonists: ancillary actions of amlodipine. Arterioscler. Thromb. Vasc. Biol. 23 (2003) 2155-2163
3. Yamagishi Sh., Nakamura K., Takenaka K., Matsui T., and Inoue H. Pleiotropic effects of nifedipine on atherosclerosis. Curr. Pharm. Design 12 (2006) 1543-1547
4. G. Duburs, B. Vigante, A. Plotniece, A. Krauze, A. Sobolevs, J. Briede, V. Klusa, A. Velena, Dihydropyridine derivatives as bioprotectors. Chim. Oggi/Chem. Today, in press.
5. Briede J., Daija D., Bisenieks E., Makarova N., Uldrikis J., Poikãns J., and Duburs G. Effects of some 1,4-dihydropyridine Ca antagonists on the blast transformation of rat spleen lymphocytes. Cell Biochem. Funct. 17 (1999) 97-105
6. Vaitkuviene A., Ulinskaite A., Meskys R., Duburs G., Klusa V., and Liutkevicius E. Study of the interaction of 1,4-dihydropyridine derivatives with glucocorticoid receptors from the rat liver. Pharmacol. Rep. 58 (2006) 551-558
7. Briede J., Stivrina M., Stoldere D., Bisenieks E., Uldrikis J., Poikãns J., Makarova N., and Duburs G. Effect of new and known 1,4-dihydropyridine derivatives on blood glucose levels in normal and streptozotocin-induced diabetic rats. Cell Biochem. Funct. 22 (2004) 219-224
8. T.M. Plotnikova, M.B. Plotnikov, G. Duburs, E.A. Bisenieks, J.R. Uldrikis, N.V. Makarova, Agent decreasing hemoglobin affinity to oxygen, Patent RU 2,061,479 (1996).
9. Luxo C., Jurado A.S., and Madeira V.M.C. Toxicity assessment of tamoxifen by means of a bacterial model. Appl. Biochem. Biotechnol. 87 (2000) 219-232
10. Videira R.A., Antunes-Madeira M.C., and Madeira V.M.C. Ethylazinphos interaction with membrane lipid organization induces increase of proton. Toxicol. Appl. Pharmacol. 175 (2001) 209-216
11. Custódio J.B.A., Almeida L.M., and Madeira V.M.C. The anticancer drug tamoxifen induces changes in the physical properties of model and native membranes. Biochem. Biophys. Acta 1150 (1993) 123-129
12. Scatena R., Bottoni P., Botta G., Martorana G.E., and Giardina B. The role of mitochondria in pharmacotoxicology: a reevaluation of an old, newly emerging topic. Am. J. Physiol. Cell Physiol. 293 (2007) C12-C21
13. Velena A.H., Dubur G.J., Vitolina R.O., Kimenis A.A., Selga M.J., Zarinsh G.V., Narusevicius E.V., Macianskiene R.A., Gendviliene V.I., and Simkhovich B.Z. Effect of ryodipine on electrochemical parameters of heart and vessels, cAMP phosphodiesterase activity and swelling-contraction cycle of mitochondria. Arzneim. -Forsch./Drug Res. 35 (1985) 907-914
14. Vitolina R.O., Berzina D.A., Velena A.H., Vucina I.A., Kimenis A.A., and Duburs G. Protective action of the calcium antagonist foridon in acute myocardial ischemia. Cardiology 27 (1987) 90-93 [in Russian]
15. Velena A., Skujins A., Svirskis S., Bisenieks E., Uldrikis J., Poikans J., Duburs G., and Klusa V. Modification of swelling-contraction-aggregation processes in rat muscle mitochondria by the 1,4-dihydropyridines, cerebrocrast und glutapyrone, themselves and in the presence of azidothymidine. Cell Biochem. Funct. 15 (1997) 211-220
16. Fernandes M.A.S., Santos M.S., Vicente J.A.F., Moreno A.J.M., Velena A., Duburs G., and Oliveira C.R. Effects of 1,4-dihydropyridine derivatives (cerebrocrast, gammapyrone, glutapyrone, and diethone) on mitochondrial bioenergetics and oxidative stress: a comparative study. Mitochondrion 3 (2003) 47-59
17. - in rat liver mitochondria. Mitochondrion 5 (2005) 341-351
18. Klusa V., and Cerebrocrast. a cognition enhancer and neuroprotectant: focus on mitochondrial functions. Auton. Autacoid Pharmacol. 26 (2006) 60-62
19. Vicente J.A.F., Duburs G., Klusa V., Brieda J., Klimaviciusa L., Zharkovsky A., and Fernandes M.A.S. In: Moreno A.J.M., Oliveira P.J., and Palmeira C.M. (Eds). Mitochondrial Pharmacology and Toxicology (2006), Transworld Research Network, Kerala 185-197
20. Belevitch G.V., Dubur G.Ya., Dobretsov G.E., Kurek N.K., and Spirin M.M. Calcium antagonists, riodipine, nifedipine and verapamil, binding to model and biological membranes: fluorescence analysis. Biol. Membr. 5 (1988) 768-776 (in Russian)
21. Gazotti P., Malmstron K., and Crompton M.A. In: Carafoli E., and Semenza G. (Eds). Membrane Biochemistry (1979), Springer Verlag, New York 62-69
22. Gornall G., Bardawill C.J., and David M.M. Determination of serum proteins by means of the biuret reaction. J. Biol. Chem. 177 (1949) 751-766
23. Kamo N., Muratsugu M., Hongoh R., and Kobatake N. Membrane potential of mitochondria measured with an electrode sensitive to tetraphenylphosphonium and relationship between proton electrochemical potential and phosphorylation potential in steady state. J. Membr. Biol. 49 (1979) 105-121
24. Koynova R.D., Boyanov A.I., and Tenchov B.G. On the phase diagram of an l-dipalmitoylphosphatidylcholine/cholesterol mixture. FEBS Lett. 187 (1985) 65-68
25. Van Dijck P.W.M., De Kruijff B., Van Deenen L.L.M., De Gier J., and Demel R.A. The presence of cholesterol for phosphatidylcholine in mixed phosphatidylcholine-phosphatidylethanolamine bilayers. Biochem. Biophys. Acta 455 (1976) 576-587
26. Bartlett G.R. Phosphorus assay in column chromatography. J. Biol. Chem. 234 (1959) 466-468
27. Böttcher C.J.F., Van Gent C.M., and Pires C. A rapid and sensitive sub-micro phosphorus determination. Anal. Chim. Acta 24 (1961) 203-204
28. Kumsar K.K., Velena A.Kh., Dubur G.Ia., Uldrikis Ia.R., and Zidermane A.A. Effect of 1,4-dihydropyridine and 1,6-dihydropyrimidine derivatives on the energy metabolism of hepatic and tumor cells. Bookhimia 36 (1971) 1204-1209 (in Russian)