Analyzing and modeling the inhibitory effect of phosphatidic acid on the GTP-γ-S binding activity of Goα

Proteins: Structure, Function and Genetics

Volumn 71, Issue 4, 2008, Pages 1732-1743

  Qu, Liang ^a   Wan, Jia ^a   Cao, Yu ^a,b   Zhang, Yinghao ^a   Chen, Runsheng ^a   Huang, Youguo ^a  

^a INSTITUTE OF BIOPHYSICS   (China)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Docking; G proteins; Go ; Inhibition; Lysophosphatidic acid; Modeling; Phoshphatidic acid

Indexed keywords

FATTY ACID; GUANINE NUCLEOTIDE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); LIPID; PHOSPHATE; PHOSPHATIDIC ACID;

ARTICLE; BINDING KINETICS; CHEMICAL ANALYSIS; CONCENTRATION RESPONSE; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LIPID INTERACTION; SEQUENCE HOMOLOGY; SPECTROSCOPY; STRUCTURE ACTIVITY RELATION;

BINDING SITES; COMPUTER SIMULATION; DATABASES, FACTUAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROSTATICS; FLUORESCENCE RESONANCE ENERGY TRANSFER; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HYDROGEN BONDING; HYDROPHOBICITY; INHIBITORY CONCENTRATION 50; LIPOSOMES; LYSOPHOSPHOLIPIDS; MODELS, MOLECULAR; PHOSPHATIDIC ACIDS; PHOSPHATIDYLSERINES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SULFUR RADIOISOTOPES;

EID: 44349083643     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.21826     Document Type: Article

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