Sexual development of mouse germ cells: Nanos2 promotes the male germ cell fate by suppressing the female pathway

Development Growth and Differentiation

Volumn 50, Issue SUPPL. 1, 2008, Pages

  Saga, Yumiko ^a  

^a NATIONAL INSTITUTE OF GENETICS   (Japan)

Author keywords

Cyp26b1; Meiosis; Nanos; Retinoic acid; Sex determination; Stra8

Indexed keywords

BINDING PROTEIN; BMS 204493; CARRIER PROTEIN; KETOCONAZOLE; N [4 [2 ETHYL 1 (1H 1,2,4 TRIAZOL 1 YL)BUTYL]PHENYL] 2 BENZOTHIAZOLAMINE; PROTEIN NANOS; PROTEIN NANOS2; PROTEIN NANOS3; RECEPTOR BLOCKING AGENT; RETINOIC ACID; RETINOIC ACID RECEPTOR; RNA BINDING PROTEIN;

CELL DIFFERENTIATION; CELL FATE; GENE; GENE EXPRESSION; GENE REPRESSION; GERM CELL; GONAD; MEIOSIS; NONHUMAN; PROTEIN FUNCTION; PROTEIN SYNTHESIS REGULATION; RECEPTOR BLOCKING; REVIEW; SEX CHROMOSOME; SEX DETERMINATION; SEXUAL DEVELOPMENT; STRA8 GENE;

ANIMALS; CARRIER PROTEINS; CELL DIFFERENTIATION; CELL LINEAGE; CHROMOSOMES; DEVELOPMENTAL BIOLOGY; FEMALE; GERM CELLS; MALE; MEIOSIS; MICE; MODELS, BIOLOGICAL; SEX DETERMINATION (GENETICS); SEX FACTORS; TRETINOIN;

EID: 44249122888     PISSN: 00121592     EISSN: 1440169X     Source Type: Journal    
DOI: 10.1111/j.1440-169X.2008.01009.x     Document Type: Review

References (22)

1. Allegrucci, C., Thurston, A., Lucas, E. Young, L. 2005. Epigenetics and the germline. Reproduction 129, 137 149.
2. Baltus, A. E., Menke, D. B., Hu, Y. C. et al. 2006. In germ cells of mouse embryonic ovaries, the decision to enter meiosis precedes premeiotic DNA replication. Nat. Genet. 38, 1430 1434.
3. Bourc'his, D. Bestor, T. H. 2004. Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L. Nature 431, 96 99.
4. Bowles, J., Knight, D., Smith, C. et al. 2006. Retinoid signaling determines germ cell fate in mice. Science 312, 596 600.
5. Byskov, A. G. Saxen, L. 1976. Induction of meiosis in fetal mouse testis in vitro. Dev. Biol. 52, 193 200.
6. Chuma, S. Nakatsuji, N. 2001. Autonomous transition into meiosis of mouse fetal germ cells in vitro and its inhibition by gp130-mediated signaling. Dev. Biol. 229, 468 479.
7. Chuma, S., Hosokawa, M., Kitamura, K. et al. 2006. Tdrd1/Mtr-1, a tudor-related gene, is essential for male germ-cell differentiation and nuage/germinal granule formation in mice. Proc. Natl Acad. Sci. USA 103, 15 894 15 899.
8. Koubova, J., Menke, D. B., Zhou, Q., Capel, B., Griswold, M. D. Page, D. C. 2006. Retinoic acid regulates sex-specific timing of meiotic initiation in mice. Proc. Natl Acad. Sci. USA 103, 2474 2479.
9. Livera, G., Rouiller-Fabre, V., Pairault, C., Levacher, C. Habert, R. 2002. Regulation and perturbation of testicular functions by vitamin A. Reproduction 124, 173 180.
10. MacLean, G., Li, H., Metzger, D., Chambon, P. Petkovich, M. 2007. Apoptotic extinction of germ cells in testes of Cyp26b1 knockout mice. Endocrinology 148, 4560 4567.
11. McLaren, A. 1984. Meiosis and differentiation of mouse germ cells. Symp. Soc. Exp. Biol. 38, 7 23.
12. McLaren, A. 2003. Primordial germ cells in the mouse. Dev. Biol. 262, 1 15.
13. McLaren, A. Southee, D. 1997. Entry of mouse embryonic germ cells into meiosis. Dev. Biol. 187, 107 113.
14. Oulad-Abdelghani, M., Bouillet, P., Decimo, D. et al. 1996. Characterization of a premeiotic germ cell-specific cytoplasmic protein encoded by Stra8, a novel retinoic acid-responsive gene. J. Cell Biol. 135, 469 477.
15. Pittman, D. L., Cobb, J., Schimenti, K. J. et al. 1998. Meiotic prophase arrest with failure of chromosome synapsis in mice deficient for Dmc1, a germline-specific RecA homolog. Mol. Cell 1, 697 705.
16. Rucker, E. B. III., Dierisseau, P., Wagner, K. U. et al. 2000. Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis. Mol. Endocrinol. 14, 1038 1052.
17. Sakai, Y., Suetake, I., Shinozaki, F., Yamashina, S. Tajima, S. 2004. Co-expression of de novo DNA methyltransferases Dnmt3a2 and Dnmt3L in gonocytes of mouse embryos. Gene Expr. Patterns 5, 231 237.
18. Seki, Y., Hayashi, K., Itoh, K., Mizugaki, M., Saitou, M. Matsui, Y. 2005. Extensive and orderly reprogramming of genome-wide chromatin modifications associated with specification and early development of germ cells in mice. Dev. Biol. 278, 440 458.
19. Suzuki, A. Saga, Y. 2008. Nanos2 suppresses meiosis and promotes male germ cell differentiation. Genes & Development 22, 430 435.
20. Suzuki, H., Tsuda, M., Kiso, M. Saga, Y. 2008. Nanos3 maintains the germ cell lineage in the mouse by supressing both Bax-dependent and -independent apoptotic pathways. Dev. Biol. in press.
21. Tsuda, M., Sasaoka, Y., Kiso, M. et al. 2003. Conserved role of nanos proteins in germ cell development. Science 301, 1239 1241.
22. Zamboni, L. Upadhyay, S. 1983. Germ cell differentiation in mouse adrenal glands. J. Exp. Zool. 228, 173 193.