Effects of intragastric agmatine on morphine-induced physiological dependence in beagle dogs and rhesus monkeys

European Journal of Pharmacology

Volumn 587, Issue 1-3, 2008, Pages 155-162

  Su, Rui Bin ^a   Lu, Xin Qiang ^a   Huang, Yu ^a   Liu, Yin ^a   Gong, Zheng Hua ^a   Wei, Xiao Li ^a   Wu, Ning ^a   Li, Jin ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

Author keywords

Agmatine; Morphine; Physiological dependence

Indexed keywords

AGMATINE; MORPHINE; NALOXONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLINICAL EVALUATION; CONTROLLED STUDY; DOG; DRUG EFFECT; DRUG INHIBITION; MALE; MOUSE; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; RAT; RHESUS MONKEY; WITHDRAWAL SYNDROME;

AGMATINE; ANALGESICS, OPIOID; ANIMALS; BEHAVIOR, ANIMAL; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; INTUBATION, GASTROINTESTINAL; MACACA MULATTA; MALE; MICE; MORPHINE; MORPHINE DEPENDENCE; NALOXONE; NARCOTIC ANTAGONISTS; RATS; RATS, WISTAR; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 44149102877     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.03.022     Document Type: Article

References (42)

1. Aricioglu F., Regunathan S., and Piletz J. Is agmatine an endogenous factor against stress?. Ann. N. Y. Acad. Sci. 1009 (2003) 127-132
2. Aricioglu F., and Uzbay I.T. Inhibitory effect of agmatine on naloxone-precipitated abstinence syndrome in morphine dependent rats. Life Sci. 61 (1997) 1775-1781
3. Aricioglu F., Means A., and Regunathan S. Effect of agmatine on the development of morphine dependence in rats: potential role of cAMP system. Eur. J. Pharmacol. 504 (2004) 191-197
4. Aricioglu F., Paul I.A., and Regunathan S. Agmatine reduces only peripheral-related behavioral signs, not the central signs, of morphine withdrawal in nNOS deficient transgenic mice. Neurosci. Lett. 354 (2004) 153-157
5. Atkins C.M., Selcher J.C., Petraitis J.J., Trzaskos J.M., and Sweatt J.D. The MAPK cascade is required for mammalian associative learning. Nat. Neurosci. 1 (1998) 602-609
6. Ernsberger P., Graves M.E., Graff L.M., Zakieh N., Nguyen P., Collins L.A., Westbrooks K.L., and Johnson G.G. I1,-imidazoline receptors: definition, characterization, distribution, and transmembrane signaling. Ann. N.Y. Acad. Sci. 763 (1995) 22-42
7. Gilad G.M., Salame K., Rabey J.M., and Gilad V.H. Agmatine treatment is neuroprotective in rodent brain injury models. Life Sci. 58 (1996) PL41-PL46
8. Gong Z.H., Li Y.F., Zhao N., Yang H.J., Su R.B., Luo Z.P., and Li J. Anxiolytic effect of agmatine in rats and mice. Eur. J. Pharmacol. 550 (2006) 112-116
9. Goracke-Postle C.J., Nguyen H.O., and Stone L.S. Release of tritiated agmatine from spinal synaptosomes. Neuroreport 17 (2006) 13-17
10. Goracke-Postle C.J., Overland A.C., Stone L.S., and Fairbanks C.A. Agmatine transport into spinal nerve terminals is modulated by polyamine analogs. J. Neurochem. 100 (2007) 132-141
11. Heidbreder C.A., and Hagan J.J. Novel pharmacotherapeutic approaches for the treatment of drug addiction and craving. Curr. Opin. Pharmacol. 5 (2005) 107-118
12. Iyo A.H., Zhu M.Y., and Ordway G.A. Expression of arginine decarboxylase in brain regions and neuronal cells. J. Neurochem. 96 (2006) 1042-1050
13. Keith D.E., Murray S.R., Zaki P.A., Chu P.C., Lissin D.V., Kang L., Evans C.J., and Von Zastrow M. Morphine activates opioid receptors without causing their rapid internalization. J. Biol. Chem. 271 (1996) 19021-19024
14. Kolesnikov Y., Jain S., and Pasternak G.W. Modulation of opioid analgesia by agmatine. Eur. J. Pharmacol. 296 (1996) 17-22
15. Kovoor A., Nappey V., Kieffer B.L., and Chavkin C. Mu and delta opioid receptors are differentially desensitized by the coexpression of beta-adrenergic receptor kinase 2 and beta-arrestin 2 in Xenopus oocytes. J. Biol. Chem. 272 (1997) 27605-27611
16. Lavinsky D., Arteni N.S., and Netto C.A. Agmatine induces anxiolysis in the elevated plus maze task in adult rats. Behav. Brain. Res. 141 (2003) 19-24
17. Li F., Wu N., Su R.B., Zheng J.Q., Xu B., Lu X.Q., Cong B., and Li J. Involvement of phosphatidylcholine selective phospholipase C in activation of mitogen-activated protein kinase pathways in imidazoline receptor antisera-selected protein. J. cell Biochem. 98 (2006) 1615-1628
18. Li J., Li X., Pei G., and Qin B.Y. Inhibitory effects of agmatine on tolerance to and substance dependence on morphine in guinea pig ileum in vitro. Acta Pharmacol. Sin. 19 (1998) 564-569
19. Li J., Li X., Pei G., and Qin B.Y. Effects of agmatine on tolerance to and substance dependence on morphine in mice. Acta Pharmacol. Sin. 20 (1999) 232-238
20. Li J., Li X., Pei G., and Qin B.Y. Correlation between inhibitions of morphine withdrawal and nitric oxide synthase by agmatine. Acta Pharmacol. Sin. 20 (1999) 375-380
21. Li J., Li X., Pei G., and Qin B.Y. Inhibition of agmatine on releasing monoamine in different brain areas of rats. P.L.A. Acta Pharma. 15 (1999) 2-7
22. Li J., Li X., Pei G., and Qin B.Y. Influence of agmatine in adaptation of cAMP signal transduction system of opiate receptors. Acta Pharmacol. Sin. 20 (1999) 592-596
23. Lu G., Su R.B., Li J., and Qin B.Y. Modulation by α-difluoromethyl-ornithine and aminoguanidine of pain threshold, morphine analgesia and tolerance. Eur J. Pharmacol. 478 (2003) 139-144
24. Lu X.Q., Su R.B., Liu Y., and Li J. Effect of agmatine on the pharmacological actions of morphine through intrathecal or intracerebroventricular injection. P.L.A. Acta Pharma. 19 (2003) 324-327
25. Morgan A.D., Campbell U.C., Fons R.D., and Carroll M.R. Effects of agmatine on the escalation of intravenous cocaine and fentanyl self-administration in rats. Pharmacol. Biochem. & Behav. 72 (2002) 873-880
26. Otake K., Ruggiero D.A., Regunathan S., Wang H., Milner T.A., and Reis D.J. Regional localization of agmatine in the rat brain: an immunocytochemical study. Brain Res. 787 (1998) 1-14
27. Regunathan S., and Piletz J. Regulation of inducible nitric oxide synthase and agmatine synthesis in macrophages and astrocytes. Ann. N. Y. Acad. Sci. 1009 (2003) 20-29
28. Piletz J., May P., and Wang G. Agmatine crosses the blood brain barrier. Ann. N. Y. Acad. Sci. 1009 (2003) 64-74
29. Reis D.J., Yang X.C., and Milner T.A. Agmatine containing axon terminals in rat hippocampus on pyramidal cells. Neurosci. Lett., 250 (1998) 185-188
30. Reis D.J., and Regunathan S. Is agmatine a novel neurotransmitter in brain?. Trends Pharmacol. Sci. 21 (2000) 187-193
31. Schulz S., and Hollt V. Opioid withdrawal activates MAP kinase in locus coeruleus neurons in morphine-dependent rats in vivo. Eur. J. Neurosci. 10 (1998) 1196-1201
32. Shalev U., Grimm J.W., and Yavin S. Neurobiology of relapse to heroin and cocaine seeking: a review. Pharmacol. Rev. 54 (2002) 1-42
33. Su R.B., Li J., Gao K., Pei G., and Qin B.Y. Influence of idazoxan on analgesia, tolerance, and physical dependence of morphine in mice and rats in vivo. Acta Pharmacol. Sin. 21 (2000) 1011-1015
34. Su R.B., Li J., Li X., and Qin B.Y. Down-regulation of MAO-B activity and imidazoline receptors in rat brain following chronic treatment of morphine. Acta Pharmacol. Sin. 22 (2001) 639-644
35. Su R.B., Li J., and Qin B.Y. Biphasic opioid function modulator: agmatine. Acta Pharmacol. Sin. 24 (2003) 631-636
36. Tempel A., and Suzanne-Zukin R. Neuroanatomical patterns of the μ, δ and κ opioid receptors of rat brain as determined by quantitative in vitro autoradiography. Proc. Natl. Acad. Sci. USA. 84 (1987) 4308-4312
37. Uzbay I.T., Yesilyurt O., Celik T., Ergun H., and Isimer A. Effects of agmatine on ethanol withdrawal syndrome in rats. Behav. Brain Res. 107 (2000) 153-159
38. Wei X.L., Su R.B., Yuan B.L., Yu S.Z., Lu X.Q., Liu Y., and Li J. Inhibition by agmatine on morphine-induced conditioned place preference in rats. Eur. J. Pharmacol. 515 (2005) 99-106
39. Wei X.L., Su R.B., Wu N., Lu X.Q., Zheng J.Q., and Li J. Agmatine inhibits morphine-induced locomotion sensitization and morphine-induced changes in striatal dopamine and metabolites in rats. Eur. Neuropsychopharmacol. 17 12 (2007) 790-799 (Dec, Electronic publication 2007 Jul 2)
40. Yabaluri N., and Medzihradsky F. Down-regulation of mu-opioid receptor by full but not partial agonists is independent of G protein coupling. Mol. Pharmacol. 52 (1997) 896-902
41. Zhang, J.T., 1998. Modern Experimental Methods in Pharmacology. Published by Beijing Medical University and Peking Union Medical College United Press, P1075.
42. Zomkowki A.D., Hammes L., Lin J., Calixto J.B., Santos A.R., and Rodrigues A.L. Agmatine produces antidepressant-like effects in two models of depression in mice. Neuroreport 13 (2002) 387-389