Agmatine inhibited tolerance to and dependence on morphine in guinea pig ileum in vitro

Acta Pharmacologica Sinica

Volumn 19, Issue 6, 1998, Pages 564-568

  Li, Jin ^a   Li, Xin ^a   Pei, Gang ^a,b   Qin, Bo Yi ^a  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

Agmatine; Clonidine; Drug tolerance; Idazoxan; Ileum; Morphine; Naloxone; Opioid related disorders; Serotonin; Yohimbine

Indexed keywords

AGMATINE; IDAZOXAN; NALOXONE; NEUROTRANSMITTER; OPIATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG DEPENDENCE; DRUG TOLERANCE; GUINEA PIG; MORPHINE ADDICTION; NONHUMAN; SUBSTANCE ABUSE;

AGMATINE; ANALGESICS, OPIOID; ANIMALS; DRUG TOLERANCE; GUINEA PIGS; ILEUM; IMIDAZOLES; MALE; MORPHINE; MORPHINE DEPENDENCE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; RECEPTORS, DRUG;

EID: 0031796338     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Nester EJ. Molecular mechanism of drug addiction. J Neuroaci 1992, 12 :2439-50.
2. Wong SC, Cheng CH, Luk HN, Ho ST, Tung CS. Effects of NMDA receptor antagonist on inhibition of morphine tolerance in rats: binding at μ-opioid receptors. Eur J Pharmacol 1996; 297: 27-30.
3. Aghajanian GK, Kogan JH, Moghaddam B. Opiate withdrawal increases glutamate and aspartate efflux in the locus coeruleus: an in vivo microdialysis study. Brain Res 1994; 636: 126-30.
4. Raasch W, Regunathan S, Li G, Reis D. Agmatine, the bacterial amine, is widely distributed in mammalian tissue. Life Sci 1995; 12: 2319-30.
5. Kolesnikov Y, Jain S, Gavril W, Pasternak GW. Modulation of opioid analgessia by agmatine. Eur J Phannacol 1996; 296: 17-22.
6. Rang HP. Stimulant actions of volatile anaesthetical on smooth muscle. Br J Pharmacol 1964; 22: 356-65.
7. Schule R, Herz A. Aspects of opiate dependence in the myenteric plexus of guinea pig. Life Sci 1996; 17: 1117-27.
8. Reis DJ, Li G, Regunathan S. Endogenous ligands of imidazoline receptors: classic and immunoreactive clonidine-displacing substance and agmatine. Ann NY Acad Sci 1995; 763: 295-313.
9. Glavin GB, Carlisle MA, Smyth DD. Agmatine, an endogenous imidazoline receptor ligand, increase gastric secretion and worsens experimental gastric mucosal injury in rats. J Pharmacol Exp Ther 1995; 274: 741-4.
10. Felsen D, Ernsberger P, Meeley MP, Reis DJ. Clonidine displacing substance is biologically active on smooth muscle. Eur J Pharmacol 1987; 142: 453-5.
11. Johnson SM, Westfall DP, Howard SA, Fleming WW. Sensitivities of isolated ileum longitudinal smooth muscle-myenteric plexus and hypogastric nerve-vas deferences guinea pig after chronic morphine pellet implantation. J Pharmacol Exp Ther 1978; 204: 54-66.