Molecular and functional MRI of the tumor microenvironment

Journal of Nuclear Medicine

Volumn 49, Issue 5, 2008, Pages 687-690

  Penet, Marie France ^a   Glunde, Kristine ^a   Jacobs, Michael A ^a   Pathak, Arvind P ^a   Bhujwalla, Zaver M ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; CONTRAST MEDIUM; GADODIAMIDE; GADOLINIUM; GADOLINIUM PENTETATE; GADOLINIUM PENTETATE MEGLUMINE; GADOTERIDOL; GADOVERSETAMIDE; HYALURONIC ACID; HYALURONIDASE; IRON OXIDE; PENTETIC ACID; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE;

BLOOD; CANCER CELL; CANCER IMMUNOTHERAPY; CELL HOMING; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; FIBROBLAST; FLUORINE NUCLEAR MAGNETIC RESONANCE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; HYPOXIA; IMMUNE SYSTEM; LEUKOCYTE; LYMPH VESSEL; LYMPHOCYTIC INFILTRATION; MELANOMA; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; PRIORITY JOURNAL; PROSTATE CANCER; PROTON NUCLEAR MAGNETIC RESONANCE; REVIEW; STROMA CELL; TUMOR; TUMOR VASCULARIZATION;

ANOXIA; EXTRACELLULAR MATRIX; HUMANS; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE IMAGING; NEOPLASMS;

EID: 44149084706     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.107.043349     Document Type: Review

References (21)

1. Mueller MM, Fusenig NE. Friends or foes: bipolar effects of the tumour stroma in cancer. Nat Rev Cancer. 2004;4:839-849.
2. Glunde K, Pathak AP, Bhujwalla ZM. Molecular-functional imaging of cancer: to image and imagine. Trends Mol Med. 2007;13:287-297.
3. Mazooz G, Mehlman T, Lai TS, et al. Development of magnetic resonance imaging contrast material for in vivo mapping of tissue transglutaminase activity. Cancer Res. 2005;65:1369-1375.
4. Shiftan L, Israely T, Cohen M, et al. Magnetic resonance imaging visualization of hyaluronidase in ovarian carcinoma. Cancer Res. 2005;65:10316-10323.
5. Pathak AP, Artemov D, Neeman M, et al. Lymph node metastasis in breast cancer xenografts is associated with increased regions of extravascular drain, lymphatic vessel area, and invasive phenotype. Cancer Res. 2006;66:5151-5158.
6. Folkman J. Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov. 2007;6:273-286.
7. Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis? Nat Rev Cancer. 2004;4:891-899.
8. Baudelet C, Cron GO, Gallez B. Determination of the maturity and functionality of tumor vasculature by MRI: correlation between BOLD-MRI and DCE-MRI using P792 in experimental fibrosarcoma tumors. Magn Reson Med. 2006;56:1041-1049.
9. Laking GR, West C, Buckley DL, et al. Imaging vascular physiology to monitor cancer treatment. Crit Rev Oncol Hematol. 2006;58:95-113.
10. Pathak AP, Gimi B, Glunde K, et al. Molecular and functional imaging of cancer: advances in MRI and MRS. Methods Enzymol. 2004;386:3-60.
11. Raman V, Artemov D, Pathak AP, et al. Characterizing vascular parameters in hypoxic regions: a combined magnetic resonance and optical imaging study of a human prostate cancer model. Cancer Res. 2006;66:9929-9936.
12. Raman V, Pathak AP, Glunde K, et al. Magnetic resonance imaging and spectroscopy of transgenic models of cancer. NMR Biomed. 2007;20:186-199.
13. Zhao D, Ran S, Constantinescu A, et al. Tumor oxygen dynamics: correlation of in vivo MRI with histological findings. Neoplasia. 2003;5:308-318.
14. 1H NMR approach to quantitative tissue oximetry using hexamethyldisiloxane. Magn Reson Med. 2006;55:743-748.
15. Granot D, Addadi Y, Kalchenko V, et al. In vivo imaging of the systemic recruitment of fibroblasts to the angiogenic rim of ovarian carcinoma tumors. Cancer Res. 2007;67:9180-9189.
16. Anderson SA, Glod J, Arbab AS, et al. Noninvasive MR imaging of magnetically labeled stem cells to directly identify neovasculature in a glioma model. Blood. 2005;105:420-425.
17. Hu DE, Kettunen MI, Brindle KM. Monitoring T-lymphocyte trafficking in tumors undergoing immune rejection. Magn Reson Med. 2005;54:1473-1479.
18. Daldrup-Link HE, Meier R, Rudelius M, et al. In vivo tracking of genetically engineered, anti-HER2/neu directed natural killer cells to HER2/neu positive mammary tumors with magnetic resonance imaging. Eur Radiol. 2005;15:4-13.
19. de Vries IJ, Lesterhuis WJ, Barentsz JO, et al. Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy. Nat Biotechnol. 2005;23:1407-1413.
20. Li C, Penet MF, Winnard P Jr, et al. Image-guided enzyme/prodrug cancer therapy. Clin Cancer Res. 2008;14:515-522.
21. Medarova Z, Pham W, Farrar C, et al. In vivo imaging of siRNA delivery and silencing in tumors. Nat Med. 2007;13:372-377.