Association of the 719Arg Variant of KIF6 With Both Increased Risk of Coronary Events and With Greater Response to Statin Therapy

Journal of the American College of Cardiology

Volumn 51, Issue 22, 2008, Pages 2195-

  Iakoubova, Olga ^a   Shepherd, James ^a   Sacks, Frank ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

CARDIOVASCULAR RISK; DRUG RESPONSE; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC VARIABILITY; HUMAN; ISCHEMIC HEART DISEASE; LETTER; PRIORITY JOURNAL;

ANTICHOLESTEREMIC AGENTS; ARGININE; CORONARY ARTERY DISEASE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; KINESIN; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 44049105242     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2008.02.061     Document Type: Letter

References (5)

1. Marian A.J. Surprises of the genome and "personalized" medicine. J Am Coll Cardiol 51 (2008) 456-458
2. Iakoubova O.A., Tong C.H., Rowland C.M., et al. Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials. J Am Coll Cardiol 51 (2008) 435-443
3. Iakoubova O.A., Sabatine M.S., Rowland C.M., et al. Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study. J Am Coll Cardiol 51 (2008) 449-455
4. Shiffman D., Chasman D.I., Zee R.Y.L., et al. A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health study. J Am Coll Cardiol 51 (2008) 444-448
5. King J.Y., Ferrara R., Tabibiazar R., et al. Pathway analysis of coronary atherosclerosis. Physiol Genomics 23 (2005) 103-118