Ephaptic conduction in a cardiac strand model with 3D electrodiffusion

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 17, 2008, Pages 6463-6468

  Mori, Yoichiro ^a   Fishman, Glenn I ^b   Peskin, Charles S ^c  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NEW YORK UNIVERSITY   (United States)

Author keywords

3D model of electrophysiology; Ephaptic coupling; Gap junction

Indexed keywords

ACTION POTENTIAL; ARTICLE; CELL ACTIVITY; DIFFUSION; ELECTRIC ACTIVITY; ELECTROPHYSIOLOGY; GAP JUNCTION; HEART CONDUCTION; HEART MUSCLE CELL; INTERMETHOD COMPARISON; MATHEMATICAL MODEL; PRIORITY JOURNAL; ANIMAL; BIOLOGICAL MODEL; CELL JUNCTION; ELECTRIC CONDUCTIVITY; ELECTRICITY; HEART; HEART MUSCLE CONDUCTION SYSTEM; MOUSE; PHYSIOLOGY;

ACTION POTENTIALS; ANIMALS; DIFFUSION; ELECTRIC CONDUCTIVITY; ELECTROSTATICS; GAP JUNCTIONS; HEART; HEART CONDUCTION SYSTEM; MICE; MODELS, CARDIOVASCULAR;

EID: 44049100052     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0801089105     Document Type: Article

References (23)

1. Guyton A, Hall J (2000) Medical Physiology (Saunders, Philadelphia), 10th Ed.
2. Hodgkin A, Huxley A (1952) A quantitative description of the membrane current and its application to conduction and excitation in nerve. J Physiol 117:500-544.
3. Keener J, Sneyd J (1998) Mathematical Physiology (Springer, New York).
4. Koch C (1999) Biophysics of Computation (Oxford Univ Press, New York).
5. Shepherd GM, ed (1997) Synaptic Organization of the Brain (Oxford Univ Press, New York).
6. Qian N, Sejnowski T (1989) An electro-diffusion model for computing membrane potentials and ionic concentrations in branching dendrites, spines and axons. Biol Cybern 62:1-15.
7. Léonetti M (1998) On biomembrane electrodiffusive models. Eur Phys J B 2:325-340.
8. Léonetti M, Dubois-Violette E, Homblé F (2004) Pattern formation of stationary transcellular ionic currents in focus. Proc Natl Acad Sci USA 101:10243-10248.
9. Mori Y, Jerome JW, Peskin CS (2007) A three-dimensional model of cellular electrical activity. Bull Inst Math Acad Sinica (Taiwan) 2:367-390.
10. Mori Y (2006) A three-dimensional model of cellular electrical activity. PhD thesis (New York Univ, New York).
11. Rohr S (2004) Role of gap junctions in the spread of the cardiac action potential. Cardiovasc Res 62:309-322.
12. Sperelakis N (2002) An electric field mechanism for transmission of excitation between myocardial cells. Circ Res 91:985-987.
13. Gutstein D, et al. (2001) Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin 43. Circ Res 88:333-339.
14. Sperelakis N, Mann JE, Jr (1977) Evaluation of electric field changes in the cleft between excitable cells. J Theor Biol 64:71-96.
15. Sperelakis N, Ramasamy L (2002) Propagation in cardiac muscle and smooth muscle based on electric field transmission at cell junctions: An analysis by PSpice. IEEE Eng Med Biol Mag 21:177-190.
16. Kucera J, Rohr S, Rudy Y (2002) Localization of sodium channels in intercalated disks modulates cardiac conduction. Circ Res 91:1176-1182.
17. Aidley D (1998) The Physiology of Excitable Cells (Cambridge Univ Press, New York), 4th Ed.
18. Hille B (2001) Ion Channels of Excitable Membranes (Sinauer, Sunderland, MA), 3rd Ed.
19. Kandel E, Schwartz J, Jessel T (2000) Principles of Neural Science (McGraw-Hill/Appleton & Lange, New York), 4th Ed.
20. Yao J, Gutstein D, Liu F, Fishman G, Wit A (2003) Cell coupling between ventricular myocyte pairs from connexin43-deficient murine hearts. Circ Res 93:736-743.
21. Bondarenko V, Szigeti G, Bett G, Kim S, Rasmusson R (2004) Computer model of action potential of mouse ventricular myocytes. Am J Physiol 287:H1378-H1403.
22. Cohen S (1994) Immunocytochemical localization of the rh1 sodium channel in adult rat heart atria and ventricle. Presence in terminal intercalated discs. Circulation 94:3083-3086.
23. Bers D (2001) Excitation-Contraction Coupling and Cardiac Contractile Force (Kluwer Academic, Dordrecht, The Netherlands).