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1
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15344350690
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Species differences in the disposition of the CCR5 antagonist, UK-427,857, a new potential treatment for HIV
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D.K. Walker S. Abel P. Comby G.J. Muirhead A.N.R. Nedderman D.A. Smith Species differences in the disposition of the CCR5 antagonist, UK-427,857, a new potential treatment for HIV Drug Metab Dispo 33 2005 587 595
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(2005)
Drug Metab Dispo
, vol.33
, pp. 587-595
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Walker, D.K.1
Abel, S.2
Comby, P.3
Muirhead, G.J.4
Nedderman, A.N.R.5
Smith, D.A.6
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3
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30744447460
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Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1
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G. Fätkenheuer A.L. Pozniak M.A. Johnson A. Plettenberg S. Staszewski A.I.M. Hoepelman Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1 Nature Med 11 2005 1170 1172
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(2005)
Nature Med
, vol.11
, pp. 1170-1172
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Fätkenheuer, G.1
Pozniak, A.L.2
Johnson, M.A.3
Plettenberg, A.4
Staszewski, S.5
Hoepelman, A.I.M.6
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4
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27744548649
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The discovery of the CCR5 receptor antagonist, UK-427,857, a new agent for the treatment of HIV infection and AIDS
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A. Wood D. Armour The discovery of the CCR5 receptor antagonist, UK-427,857, a new agent for the treatment of HIV infection and AIDS Progr Medicin Chem 43 2005 239 271
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(2005)
Progr Medicin Chem
, vol.43
, pp. 239-271
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Wood, A.1
Armour, D.2
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5
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27644510382
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Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broadspectrum anti-human immunodeficiency virus type 1 activity
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P. Dorr M. Westby S. Dobbs P. Griffin B. Irvine M. Macartney Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broadspectrum anti-human immunodeficiency virus type 1 activity Anti-microb Agents Chemother 49 2005 4721 4732
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(2005)
Anti-microb Agents Chemother
, vol.49
, pp. 4721-4732
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Dorr, P.1
Westby, M.2
Dobbs, S.3
Griffin, P.4
Irvine, B.5
Macartney, M.6
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6
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85119731430
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Investigation of the pharmacokinetics of maraviroc following IV dosing, and determination of absolute bioavailability following 100 mg oral dosing [abstract]
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th International Workshop on Clinical Pharmacology of HIV Therapy Lisbonne, Portugal, avril 2006 2006 Abstract 59A
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(2006)
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Abel, S.1
Russell, D.2
Whitlock, L.3
Ridgway, C.4
Weissgerber, G.5
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7
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85119772744
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Investigation of the population pharmacokinetics of maraviroc following IV dosing [abstract]
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th International Workshop on Clinical Pharmacology of HIV Therapy 2006 Abstract 59B
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(2006)
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Weatherley, B.1
McFadyen, L.2
Abel, S.3
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8
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85119766667
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Population pharmacokinetics of phase 1/2a data after oral tablet administration of maraviroc – a novel residual error model [abstract]
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th International Workshop on Clinical Pharmacology of HIV Therapy 2007 Abstract 16
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(2007)
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Chan, P.L.S.1
Weatherley, B.2
McFadyen, L.3
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9
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85119740586
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An open, parallel group study to compare the pharmacokinetics, safety and toleration of a single oral dose of maraviroc in subjects with mild and moderate hepatic impairment with subjects with normal hepatic function [abstract]
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th International Workshop on Clinical Pharmacology of HIV Therapy Budapest, Hongrie. avril 2007 2007 Abstract 8
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(2007)
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Abel, S.1
Ridgway, C.2
Hamlin, J.3
Davis, J.4
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10
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85119758508
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The effect of P450 inducers on the pharmacokinetics of CCR5 antagonist, UK-427,857, in healthy volunteers [abstract]
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th International Workshop on Clinical Pharmacology of HIV Therapy Rome, Italie, avril 2004 2004 Abstract 5.4
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(2004)
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Jenkins, T.1
Abel, S.2
Russell, D.3
Boucher, M.4
Whitlock, L.5
Weissgerber, G.6
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13
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84884911365
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An investigation of the effects of atazanavir and ritonavir boosted atazanavir on the pharmacokinetics of the novel CCR5 inhibitor UK-427,857 [abstract]
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th International Congress on Drug Therapy in HIV infection Glasgow, Royaume Uni, novembre 2004 2004 Abstract P283
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(2004)
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Muirhead, G.1
Abel, S.2
Russell, D.3
Hackman, F.4
Taylor-Worth, R.5
Toh, M.6
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14
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85119765173
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A study to investigate the combined co-administration of P450 CYP3A4 inhibitors and inducers on the pharmacokinetics of the novel CCR5 inhibitor UK-427,857 [abstract]
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th International Congress on Drug Therapy in HIV infection Glasgow, Royaume Uni, novembre 2004 2004 Abstract P284
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(2004)
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Russell, D.1
Ridgway, C.2
Mills, C.3
van der Merwe, R.4
Muirhead, G.5
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15
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85119782039
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Overview of the drug-drug interaction data for maraviroc (UK-427,857) [abstract]
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th International Workshop on Clinical Pharmacology of HIV Therapy Québec, Canada, avril 2005 2005 Abstract 76
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(2005)
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Abel, S.1
Russell, D.2
Ridgway, C.3
Muirhead, G.4
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16
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29744462285
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A novel probe drug interaction study to investigate the effect of selected ARV combinations on the PK of a single oral dose of maraviroc in HIV positive subjects [abstract]
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th International Workshop on Clinical Pharmacology of HIV Therapy Québec, Canada, avril 2005 2005 Abstract 31
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(2005)
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Muirhead, G.1
Russell, D.2
Pozniak, A.3
Boffito, M.4
Moyle, G.J.5
Gazzard, B.6
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19
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84884915901
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An open, randomized, 2-way crossover study to investigate the effect of darunavir/ritonavir on the pharmacokinetics of maraviroc in healthy subjects [abstract]
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th International Workshop on Clinical Pharmacology of HIV Therapy Budapest, Hongrie, avril 2007 2007 Abstract 55
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(2007)
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Abel, S.1
Ridgway, C.2
Hamlin, J.3
Davis, J.4
Mack, R.5
Sekar, V.6
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20
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85119776595
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Impact of concomitant interacting drugs on maraviroc pharmacokinetics after oral tablet administration [abstract]
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th International Workshop on Clinical Pharmacology of HIV Therapy Budapest, Hongrie, avril 2007 2007 Abstract 65
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(2007)
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Chan, P.L.S.1
Weatherley, B.2
McFadyen, L.3
Abel, S.4
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85119782173
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