The tryptophan synthetase gene TRP1 of Nodulisporium sp.: Molecular characterization and its relation to nodulisporic acid a production

Applied Microbiology and Biotechnology

Volumn 79, Issue 3, 2008, Pages 451-459

  Ireland, C ^a   Peekhaus, N ^a   Lu, P ^a   Sangari, R ^a   Zhang, A ^a   Masurekar, P ^a   An, Z ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Nodulisporic acid A; Nodulisporium sp; Trytophan synthetase

Indexed keywords

CONCENTRATION (PROCESS); ENZYMES; FUNGI; GROWTH KINETICS; INSECTICIDES; ORGANIC ACIDS;

MOLECULAR CHARACTERIZATION; NODULISPORIC ACIDS; TRYTOPHAN SYNTHETASE;

GENES;

AMINO ACID; HYGROMYCIN; INSECTICIDE; NODULISPORIC ACID A; TRYPTOPHAN;

CLONE; CONCENTRATION (COMPOSITION); ENZYME ACTIVITY; FUNGUS; INSECTICIDE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; AUXOTROPHY; BIOSYNTHESIS; CONTROLLED STUDY; EXON; FERMENTATION; FUNGUS; GENE MAPPING; GENE MUTATION; GENETIC ANALYSIS; GENETIC CODE; INTRON; MOLECULAR CLONING; MUTATOR GENE; NODULISPORIUM; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; POLYADENYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA TRANSLATION; STOP CODON; TRANSCRIPTION INITIATION; TRP1 GENE;

ASCOMYCOTA; BIOSYNTHETIC PATHWAYS; CLONING, MOLECULAR; DNA, FUNGAL; FERMENTATION; FUNGAL PROTEINS; FUNGI; INDOLES; KINETICS; MOLECULAR SEQUENCE DATA; MUTATION; POLYADENYLATION; TRANSCRIPTION INITIATION SITE; TRYPTOPHAN; TRYPTOPHAN SYNTHASE;

FUNGI; NODULISPORIUM;

EID: 43949138235     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-008-1440-3     Document Type: Article

References (28)

1. An Z, Farman ML, Budde A, Taura S, Leong SA (1996) New cosmid vectors for library construction, chromosome walking and restriction mapping in filamentous fungi. Gene 176:93-96
2. Ballance DJ (1991) Transformation systems for filamentous fungi and an overview of fungal gene structure. In: Leong SA, Berka RM (eds) Molecular industrial mycology: systems and applications for filamentous fungi. Marcel Dekker, New York, pp 1-29
3. Binninger DM, Skrzynia C, Pukkila PJ, Casselton LA (1987) DNA-mediated transformation of the basidiomycete Coprinus cinereus. EMBO J 6:835-840
4. Bowden DW, Muller-Kahle H, Fulton TR, Gravius TC, Barker DF, Donis-Keller H (1988) Studies on locus expression, library representation, and chromosome walking using an efficient method to screen cosmid libraries. Gene 71:391-400
5. Bruchez JJP, Eberle J, Russo VEA (1993) Regulatory sequences involved in the translation of Neurospora crassa mRNA: Kozak sequences and stop codons. Fungal Genet Newslett 40:85-88
6. Burns DM, Horn V, Paluh J, Yanofsky C (1990) Evolution of the tryptophan synthetase of fungi: analysis of experimentally fused Escherichia coli tryptophan synthetase alpha and beta chains. J Biol Chem 265:2060-2069
7. Burns DM, Yanofsky C (1989) Nucleotide sequence of the Neurospora crassa trp-3 gene encoding tryptophan synthetase and comparison of the trp-3 polypeptide with its homologs in Saccharomyces cerevisiae and Escherichia coli. J Biol Chem 264:3840-3848
8. Byrd AD, Schardl CL, Songlin PJ, Mogen KL, Siegel MR (1990) The b-tubulin gene of Epichloe typhina from perennial ryegrass (Lolium perenne). Curr Genet 18:347-354
9. Byrne KM, Smith SK, Ondeyka JG (2002) Biosynthesis of nodulisporic acid A: precusor studies. J Am Chem Soc 124:7055-7076
10. Eckert SE, Kubler E, Hoffmann B, Braus GH (2000) The tryptophan synthase-encoding trpB gene of Aspergillus nidulans is regulated by the cross-pathway control system. Mol Gen Genet 263:867-876
11. Floss HG, Mothes U (1964) Uber den Einfluss von Tryptophan und analogen Verbindungan auf die Biosynthese von Clavinalkaloiden in saprophytischer Kultur. Arch Mikrobiol 48:213-221
12. Fulton TR, Ibrahim N, Losada MC, Grzegorski D, Tkacz JS (1999) A melanin polyketide synthase (PKS) gene from Nodulisporium sp. that shows homology to the pks1 gene of Colletotrichum lagenarium. Mol Gen Genet 262:714-720
13. Krupinski VM, Robbers JE, Floss HG (1976) Physiological study of ergot: induction of alkaloid synthesis by tryptophan at the enzymatic level. J Bacteriol 125:158-165
14. Marfey P (1984) Determination of D-amino acids. II. Use of a bifunctional reagent, 1,5-difluoro-2,4-dinitrobenzene. Carlsberg Res Commun 49:591-596
15. Monaghan RL, Polishook JD, Pecore V, Bills GF, Nallin-Omstead M, Streicher SL (1995) Discovery of novel secondary metabolites from fungi-is it really a random walk through a random forest. Can J Bot 73(S1):S923-S931
16. Ondeyka JG, Helms GL, Hensens OD, Goetz MA, Zink DL, Tsipouras A, Shoop WL, Slayton L, Dombrowski AW, Polishook JD, Ostlind DA, Tsou NN, Ball RG, Singh SB (1997) Nodulisporic acid A, a novel and potent insecticide from Nodulisporium sp. Isolation, structure determination, and chemical transformations. J Am Chem Soc 119:8809-8816
17. Ostlind DA, Felcetto T, Misura A, Ondeyka J, Smith S, Goetz M, Shoop W, Mickle W (1997) Discovery of a novel indole diterpene insecticide using first instars of Lucilia sericata. Med Vet Entomolo 11:407-408
18. Polishook JD, Ondeyka JG, Dombrowski AW, Pelaez F, Platas G, Teran AM (2001) Biogeography and relatedness of Nodulisporium strains producing nodulisporic acid. Mycologia 93:1125-1137
19. Radford A, Parish JH (1997) The genome and genes of Neurospora crassa. Fungal Genet Biol 21:258-266
20. Rodrigues KF, Samuels GJ (1990) Preliminary study of endophytic fungi in a tropical palm. Mycological Research 94:827-830
21. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
22. Shoop WL, Gregory LM, Zakson-Aiken M, Michael BF, Haines HW, Ondeyka JG, Meinke PT, Schmatz DM (2001) Systemic efficacy of nodulisporic acid against fleas on dogs. J Parasitol 87:419-423
23. Skrzynia C, Binninger DM, Alspaugh JA, Pukkila PJ (1989) Molecular characterization of TRP1, a gene coding for tryptophan synthetase in the basidiomycete Coprinus cinereus. Gene 81:73-82
24. Smith MM, Warren VA, Thomas BS, Brochu RM, Ertel EA, Rohrer S, Schaeffer J, Schmatz D, Petuch BR, Tang YS, Meinke PT, Kaczorowski GJ, Cohen CJ (2000) Nodulisporic acid opens insect glutamate-gated chloride channels: identification of a new high affinity modulator. Biochemistry 39:5543-5554
25. Vining LC (1970) Effect of tryptophan on alkaloid biosynthesis in cultures of a Claviceps species. Can J Microbiol 16:473-480
26. Yanofsky C (1984) Comparison of regulatory and structural regions of genes of tryptophan metabolism. Mol Biol Evol 1:143-161
27. Yelton MM, Hamer JE, Timberlake WE (1984) Transformation of Aspergillus nidulans by using a trpC plasmid. Proc Natl Acad Sci U S A 81:1470-1474
28. Zalkin H, Yanofsky C (1982) Yeast gene TRP5: structure, function, regulation. J Biol Chem 257:1491-1500