PPAR-α ligands as potential therapeutic agents for wet age-related macular degeneration

PPAR Research

Volumn , Issue , 2008, Pages

  Gehlbach, Peter L ^a   Del V Cano, Marisol ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; FENOFIBRATE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIRINIXIC ACID; RANIBIZUMAB; VASCULOTROPIN; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; CLINICAL TRIAL; DRUG MECHANISM; HUMAN; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RETINA MACULA AGE RELATED DEGENERATION; REVIEW; SIGNAL TRANSDUCTION; TREATMENT OUTCOME; VISUAL ACUITY;

EID: 43949121929     PISSN: 16874757     EISSN: 16874765     Source Type: Journal    
DOI: 10.1155/2008/821592     Document Type: Review

References (51)

1. Klein R., Klein B. E., Linton K. L., Prevalence of age-related maculopathy. The Beaver Dam Eye Study Ophthalmology 1992 99 6 933 943
2. Kinose F., Roscilli G., Lamartina S., Inhibition of retinal and choroidal neovascularization by a novel KDR kinase inhibitor Molecular Vision 2005 11 366 373
3. Muñoz B.
4. Klein R., Klein B. E., Jensen S. C., Meuer S. M., The five-year incidence and progression of age-related maculopathy. The Beaver Dam Eye Study Ophthalmology 1997 104 1 7 21
5. Leibowitz H. M., Krueger D. E., Maunder L. R., The Framingham Eye Study monograph: an ophthalmological and epidemiological study of cataract, glaucoma, diabetic retinopathy, macular degeneration, and visual acuity in a general population of 2631 adults, 1973-1975 Survey of Ophthalmology 1980 24, supplement 1 335 610
6. Ng E. W. M., Shima D. T., Calias P., Cunningham E. T. Jr., Guyer D. R., Adamis A. P.
7. Heier J. S., Antoszyk A. N., Pavan P. R., Ranibizumab for treatment of neovascular age-related macular degeneration. A phase I/II multicenter, controlled, multidose study Ophthalmology 2006 113 4 633 642
8. Michels S.
9. Michels S., Rosenfeld P. J.
10. Avery R. L., Pieramici D. J., Rabena M. D., Castellarin A. A., Nasir M. A., Giust M. J., Intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration Ophthalmology 2006 113 3 363 372
11. Bonne C.
12. Chang F., Jaber L. A., Berlie H. D., O'Connell M. B.
13. Braissant O., Foufelle F., Scotto C., Dauca M., Wahli W., Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR- α,-β, and-γ in the adult rat Endocrinology 1996 137 1 354 366
14. Auboeuf D., Rieusset J., Fajas L., Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor- α in humans: no alteration in adipose tissue of obese and NIDDM patients Diabetes 1997 46 8 1319 1327
15. Lemberger T., Braissant O., Juge-Aubry C., PPAR tissue distribution and interactions with other hormone-signaling pathways Annals of the New York Academy of Sciences 1996 804 231 251
16. Staels B., Koenig W., Habib A., Activation of human aortic smooth-muscle cells is inhibited by PPAR α but not by PPAR γ activators Nature 1998 393 6687 790 793
17. Inoue I., Shino K., Noji S., Awata T., Katayama S., Expression of peroxisome proliferator-activated receptor α (PPAR α) in primary cultures of human vascular endothelial cells Biochemical and Biophysical Research Communications 1998 246 2 370 374
18. Chinetti G., Griglio S., Antonucci M., Activation of proliferator- activated receptors α and γ induces apoptosis of human monocyte-derived macrophages Journal of Biological Chemistry 1998 273 40 25573 25580
19. Cousins S. W.
20. Chawla A., Schwarz E. J., Dimaculangan D. D., Lazar M. A., Peroxisome proliferator-activated receptor (PPAR) γ: adipose-predominant expression and induction early in adipocyte differentiation Endocrinology 1994 135 2 798 800
21. Auwerx J., Martin G., Guerre-Millo M., Staels B., Transcription, adipocyte differentiation, and obesity Journal of Molecular Medicine 1996 74 7 347 352
22. Komers R., Vrana A., Thiazolidinediones-tools for the research of metabolic syndrome X Physiological Research 1998 47 4 215 225
23. Itoh H.
24. Plutzky J., Peroxisome proliferator-activated receptors in endothelial cell biology Current Opinion in Lipidology 2001 12 5 511 518
25. Giaginis C., Margeli A., Theocharis S.
26. Meissner M., Stein M., Urbich C., PPAR α activators inhibit vascular endothelial growth factor receptor-2 expression by repressing Sp1-dependent DNA binding and transactivation Circulation Research 2004 94 3 324 332
27. Varet J., Vincent L., Mirshahi P., Fenofibrate inhibits angiogenesis in vitro and in vivo Cellular and Molecular Life Sciences 2003 60 4 810 819
28. Chen X. R., Besson V. C.
29. Bordet R.
30. Arca M., Natoli S., Micheletta F., Increased plasma levels of oxysterols, in vivo markers of oxidative stress, in patients with familial combined hyperlipidemia: reduction during atorvastatin and fenofibrate therapy Free Radical Biology and Medicine 2007 42 5 698 705
31. Han S. H., Quon M. J., Koh K. K.
32. Israelian-Konaraki Z., Reaven P. D.
33. Marx N., Schönbeck U., Lazar M. A., Libby P., Plutzky J.
34. Iglarz M., Touyz R. M., Amiri F., Lavoie M.-F., Diep Q. N., Schiffrin E. L.
35. Delerive P., Fruchart J. C., Staels B., Peroxisome proliferator-activated receptors in inflammation control Journal of Endocrinology 2001 169 3 453 459
36. Ferrara N.
37. Kulkarni A. D., Kuppermann B. D.
38. Ferrara N., The role of VEGF in the regulation of physiological and pathological angiogenesis EXS 2005 94 209 231
39. Kvanta A., Algvere P. V., Berglin L., Seregard S., Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothelial growth factor Investigative Ophthalmology and Visual Science 1996 37 9 1929 1934
40. Lopez P. F., Sippy B. D., Lambert H. M., Thach A. B., Hinton D. R., Transdifferentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neovascular membranes Investigative Ophthalmology and Visual Science 1996 37 5 855 868
41. Kliffen M., Sharma H. S., Mooy C. M., Kerkvliet S., de Jong P. T., Increased expression of angiogenic growth factors in age-related maculopathy British Journal of Ophthalmology 1997 81 2 154 162
42. Wells J. A., Murthy R., Chibber R., Levels of vascular endothelial growth factor are elevated in the vitreous of patients with subretinal neovascularisation British Journal of Ophthalmology 1996 80 4 363 366
43. Simorre-Pinatel V., Guerrin M., Chollet P., Vasculotropin-VEGF stimulates retinal capillary endothelial cells through an autocrine pathway Investigative Ophthalmology and Visual Science 1994 35 9 3393 3400
44. Aiello L. P., Northrup J. M., Keyt B. A., Takagi H., Iwamoto M. A., Hypoxic regulation of vascular endothelial growth factor in retinal cells Archives of Ophthalmology 1995 113 12 1538 1544
45. Adamis A. P., Shima D. T., Yeo K. T., Synthesis and secretion of vascular permeability factor/vascular endothelial growth factor by human retinal pigment epithelial cells Biochemical and Biophysical Research Communications 1993 193 2 631 638
46. Pierce E. A., Avery R. L., Foley E. D., Aiello L. P., Smith L. E. H., Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization Proceedings of the National Academy of Sciences of the United States of America 1995 92 3 905 909
47. Yokoyama Y.
48. Pola R.
49. Murata T., He S., Hangai M., Peroxisome proliferator-activated receptor- γ ligands inhibit choroidal neovascularization Investigative Ophthalmology and Visual Science 2000 41 8 2309 2317
50. Zandbergen F., Plutzky J.
51. Hogg R., Chakravarthy U., AMD and micronutrient antioxidants Current Eye Research 2004 29 6 387 401