Eliminating the synthesis of mature lamin A reduces disease phenotypes in mice carrying a Hutchinson-Gilford progeria syndrome allele

Journal of Biological Chemistry

Volumn 283, Issue 11, 2008, Pages 7094-7099

  Yang, Shao H ^a   Qiao, Xin ^a   Farber, Emily ^a   Chang, Sandy Y ^a   Fong, Loren G ^a,b   Young, Stephen G ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; HISTOLOGY; REAL TIME SYSTEMS;

BODY WEIGHTS; COMPOSITIONAL CHANGES; LAMIN A; MUTANT ALLELES; NUCLEAR LAMINAS; SYNTHESIS OF;

FIBROBLASTS;

LAMIN A; LAMIN C; PROGERIN; UNCLASSIFIED DRUG; NUCLEAR PROTEIN; PRELAMIN A; PROTEIN PRECURSOR;

ALLELE; ANIMAL CELL; ANIMAL MODEL; ARTICLE; BODY WEIGHT; DISEASE SEVERITY; EMBRYO; FIBROBLAST; MALE; MODULATION; MOUSE; MUTANT; NONHUMAN; NUCLEAR LAMINA; NUCLEAR SHAPE; PHENOTYPE; PRIORITY JOURNAL; PROGERIA; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; RIB FRACTURE; STEADY STATE; SURVIVAL; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL NUCLEUS; DISEASE MODEL; FRACTURE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM;

MUS;

ALLELES; ANIMALS; CELL NUCLEUS; DISEASE MODELS, ANIMAL; FIBROBLASTS; FRACTURES, BONE; GENE EXPRESSION REGULATION; LAMIN TYPE A; MALE; MICE; MICE, INBRED C57BL; NUCLEAR PROTEINS; PHENOTYPE; PROGERIA; PROTEIN PRECURSORS;

EID: 43749111384     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M708138200     Document Type: Article

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