Blinding the blinded - Assessing the effectiveness of a sham treatment in a multiplace hyperbaric chamber trial

Diving and Hyperbaric Medicine

Volumn 38, Issue 1, 2008, Pages 3-7

  Rainolds, Dan ^a   Long, Robert ^a  

^a Wesley Ctr for Hyperbaric Medicine   (Australia)

Author keywords

Hyperbaric facilities; Hyperbaric oxygen; Hyperbaric research; Profile

Indexed keywords

OXYGEN;

ADULT; ARTICLE; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DECOMPRESSION SICKNESS; DIVER; FEMALE; HUMAN; HUMAN EXPERIMENT; HYPERBARIC OXYGEN; MALE; METHODOLOGY; MIDDLE EAR PRESSURE; PILOT STUDY; PRESSURE CHAMBER; PRESSURE GRADIENT; PRESSURE SENSATION; RANDOMIZED CONTROLLED TRIAL; SHAM PROCEDURE;

EID: 43749105754     PISSN: 18333516     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Nilsson Remahl AI, Ansjon R, Lind F, Waldenlind E. Hyperbaric oxygen treatment of active cluster headache: a double-blind placebo-controlled cross-over study. Cephalalgia. 2002; 22: 730-9.
2. Van Ophoven A, Rossbach G, Pajonk F, Hertle L. Safety and efficacy of hyperbaric oxygen therapy for the treatment of interstitial cystitis: a randomized, sham controlled, double-blind trial. J Urol. 2006; 176 (4 Pt 1): 1442-6.
3. Scheinkestel CD, Bailey M, Myles PS, Jones K, Cooper DJ, et al. Hyperbaric or normobaric oxygen for acute carbon monoxide poisoning: a randomised controlled clinical trial. Med J Aust. 1999; 170: 203-10.
4. Bouachour G, Cronier P, Gouello JP, Toulemonde JL, Talha A, Alquier P. Hyperbaric oxygen therapy in the management of crush injuries: a randomized double-blind placebo-controlled clinical trial. J Trauma. 1996; 41: 333-9.
5. Armitage P, Berry G. Statistical methods in medical research, 3rd ed. Oxford: Blackwell Science; 1994. p. 195.
6. Jones B, Jarvis P, Lewis JA, Ebbutt AF. Trials to assess equivalence: the importance of rigorous methods. BMJ. 1996; 7048: 36-9.
7. Newcombe R. Interval estimation for the difference between independent proportions: comparison of eleven methods. Stat Med. 1998; 17: 873-90.
8. Boutron I, Estellat C, Guittet L, Dechartres A, Sackett D, et al. Methods of blinding in reports of randomized controlled trials assessing pharmacologic treatments: A systemic review. PLoS Med. 2006; 3(10): e425.
9. Haahr M, Hrobjartsson A. Who is blinded in randomized clinical trials? A study of 200 trials and a survey of authors. Clin Trials. 2006; 3: 360-5.
10. Boutron I, Estellat C, Ravaud P. A review of blinding in randomized controlled trials found results inconsistent and questionable. J Clin Epidemiol. 2005; 58: 1220-6.
11. Bown R. Scurvy: How a surgeon, a mariner and a gentleman solved the greatest medical mystery of the age of sail. Canada: Thomas Allen Publishers; 2003.