Who is blinded in randomized clinical trials? A study of 200 trials and a survey of authors

Clinical Trials

Volumn 3, Issue 4, 2006, Pages 360-365

  Haahr, Mette Thorlund ^a   Hróbjartsson, Asbjørn ^a  

^a Rigshospitalet   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; AUTHOR; CLINICAL RESEARCH; CLINICAL TRIAL; COCHRANE LIBRARY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HEALTH CARE PERSONNEL; HUMAN; INFORMATION PROCESSING; MEDICAL LITERATURE; METHODOLOGY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; QUESTIONNAIRE; RANDOMIZATION; SYSTEMATIC ERROR;

DOUBLE-BLIND METHOD; HUMANS; PUBLISHING; QUESTIONNAIRES; RANDOMIZED CONTROLLED TRIALS; SINGLE-BLIND METHOD;

EID: 33750444213     PISSN: 17407745     EISSN: 17407753     Source Type: Journal    
DOI: 10.1177/1740774506069153     Document Type: Article

References (11)

1. Jüni P, Altman DG, Egger M. Systematic reviews in health care: Assessing the quality of controlled clinical trials. Br Med J 2001; 323: 42-46.
2. Noseworthy JH, Ebers GC, Vandervoort MK, Farquhar RE, Yetisir E, Roberts R. The impact of blinding on the results of a randomized, placebo-controlled multiple sclerosis clinical trial. Neurology 1994; 44: 16-20.
3. Montori VM, Bhandari M, Devereaux PJ, Manns BJ, Ghali WA, Guyatt GH. In the dark. The reporting of blinding status in randomized controlled trials. J Clin Epidemiol 2002; 55: 787-90.
4. Moher D, Schulz KF, Altman DG. The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials. Lancet 2001; 357: 1191-94.
5. http://www.consort-statement.org/Endorsements/Journals/journals. html. Accessed 4 September 2005.
6. Asch DA, Jedrziewski MK, Christakis NA. Response rates to mail surveys published in medical journals. J Clin Epidemiol 1997; 50: 1129-36.
7. Chan AW, Hrobjartsson A, Haahr MT, Gotzsche PC, Altman DG. Empirical evidence for selective reporting of outcomes in randomized trials: comparison of protocols to published articles. JAMA 2004; 291: 2457-65.
8. Hill CL, LaValley MP, Felson DT. Discrepancy between published report and actual conduct of randomized clinical trials. J Clin Epidemiol 2002; 55: 783-86.
9. Devereaux PJ, Choi PT, El-Dika S et al. An observational study found that authors of randomized controlled trials frequently use concealment of randomization and blinding, despite the failure to report these methods. J Clin Epidemiol 2004; 57: 1232-36.
10. Devereaux PJ, Manns BJ, Ghali WA et al. Physician interpretation and textbook definitions of blinding terminology in randomized controlled trials. JAMA 2001; 285: 2000-2003.
11. Chan AW, Altman DG. Epidemiology and reporting of randomised trials published in PubMed journals. Lancet 2005; 365: 1159-62.