Production of arachidonic acid and dihomo-γ-linolenic acid from glycerol by oil-producing filamentous fungi, Mortierella in the ARS culture collection

Journal of Industrial Microbiology and Biotechnology

Volumn 35, Issue 6, 2008, Pages 501-506

  Hou, Ching T ^a  

^a NATIONAL CENTER FOR AGRICULTURAL UTILIZATION RESEARCH   (United States)

Author keywords

Arachidonic acid; Bioglycerin; Dihomo linolenic acid; Mortirella

Indexed keywords

ARACHIDONIC ACID; DIHOMO GAMMA LINOLENIC ACID; GLUCOSE; GLYCEROL;

ARTICLE; CELL GROWTH; CONTROLLED STUDY; FATTY ACID ANALYSIS; FATTY ACID SYNTHESIS; FUNGAL STRAIN; FUNGUS GROWTH; LIPID COMPOSITION; MORTIERELLA; NONHUMAN; PH; TEMPERATURE SENSITIVITY;

8,11,14-EICOSATRIENOIC ACID; ARACHIDONIC ACID; FATTY ACIDS; GLYCEROL; HYDROGEN-ION CONCENTRATION; MORTIERELLA; SPECIES SPECIFICITY; TEMPERATURE; TIME FACTORS; UNITED STATES; UNITED STATES DEPARTMENT OF AGRICULTURE;

FUNGI; MORTIERELLA; MORTIERELLA ALPINA; MORTIERELLA ELONGATA; MORTIERELLA HYGROPHILA; MORTIERELLA PARVISPORA;

EID: 43749092781     PISSN: 13675435     EISSN: 14765535     Source Type: Journal    
DOI: 10.1007/s10295-008-0308-y     Document Type: Article

References (14)

1. Horrobin DF (1992) Nutritional and medical importance of γ-linolenic acid. Prog Lipid Res 31:163-194
2. 5-desaturase- defective mutant of Mortierella alpina 1S-4. Appl Environ Microbiol 58:2196-2200
3. 6-desaturase-defective mutant of the fungus Mortierella alpina 1S-4. Biochem Biophys Acta 1167:137-141
4. 12 desaturase-defective mutant of Mortierella alpina 1S-4. J Am Oil Chem Soc 70:119-123
5. Needleman P, Turk J, Jakschik BA, Morrison AR, Lefkowith JB (1986) Arachidonic acid metabolism. Annu Rev Biochem 55:69-102
6. 12-fatty acid desaturase from arachidonic acid-producing Mortierella fungus by heterologous expression in yeast Sacharomyces serevisiae and the fungus Aspergillus oryzae. Eur J Biochem 261:812-820
7. 6-Fatty acid desaturase from an arachidonic acid-pproducing Mortierella fungus. Gene cloning and its heterologous expression in a fungus Aspergillus. Gene 238:445-453
8. 9-Fatty acid desaturase from arachidonic acid-producing fungus. Unique gene sequence and its heterologous expression in a fungus, Aspergillus. Eur J Biochem 260:208-216
9. Shimizu S, Ogawa J, Kataoka M, Kobayashi M (1997) Screening of novel microbial enzymes for the production of biologically and chemically useful compounds. In: Shepter T (ed) Advances in biochemical engineering/biotechnology, vol 58. Springer, Berlin, pp 45-87
10. Smith WL, Borgeat P (1985) The eicosanoids: prostagrandins, thromboxanes, leukotrienes, and hydroxyl-eicosanoic acid. In: Vance DE, Vance JE (ed) Biochemistry of lipids and membrances. Benjamin/Cummings, Menlo Park, pp 326-360
11. Takeno S, Sakuradani E, Tomi A, Inohara-Ochiai M, Kawashima H, Ashikari T, Shimizu S (2005) Improvement of the fatty acid composition of an oil-producing filamentous fungus, Mortierella alpine 1S-4, through RNA interference with Δ-12-desaturase gene expression. Appl Environ Microbiol 71:5124-5128
12. Wynn JP, Hamid AA, Ratledge C (1999) The role of malic enzyme in the regulation of lipid accumulation in filamentous fungi. Microbiology 145:1911-1917
13. Wynn JP, Ratledge C (2000) Evidence that the rate-limiting step for the biosynthesis of arachidonic acid in Mortierella alpine is at the level of the 18:3 to 20:3 elongase. Microbiology 146:2325-2331
14. Yamada H, Shimizu S, Shinmen Y (1987) Production of arachidonic acid by Mortierella elongate 1S-5. Agric Biol Chem 51:785-790