Evidence for the existence of an estrogen-responsive sexually dimorphic group of cells in the medial preoptic area of the 129SvEv mouse strain

International Journal of Impotence Research

Volumn 20, Issue 3, 2008, Pages 315-323

  Hill, R A ^a,b   Simpson, E R ^a,b   Boon, W C ^a  

^a MONASH MEDICAL CENTRE   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

Aromatase; Galanin; Medial preoptic area; Sexual dimorphism

Indexed keywords

AROMATASE; ESTROGEN; GALANIN; TESTOSTERONE;

ANALYTIC METHOD; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; KNOCKOUT MOUSE; MEDIAL PREOPTIC AREA; MOUSE; MOUSE STRAIN; NISSL SUBSTANCE; NONHUMAN; PRIORITY JOURNAL; SEX DIFFERENCE; SEXUAL BEHAVIOR;

ANIMALS; AROMATASE; ESTROGENS; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; PREOPTIC AREA; SEX CHARACTERISTICS;

EID: 43649099261     PISSN: 09559930     EISSN: 14765489     Source Type: Journal    
DOI: 10.1038/ijir.2008.2     Document Type: Article

References (36)

1. Gorski RA. Sexual differentiation of the brain. Hosp Pract 1978; 13: 55-62.
2. Gorski RA, Harlan RE, Jacobson CD, Shryne JE, Southam AM. Evidence for the existence of a sexually dimorphic nucleus in the preoptic area of the rat. J Comp Neurol 1980; 193: 529-539.
3. Brown AE, Mani S, Tobet SA. The preoptic area/anterior hypothalamus of different strains of mice: sex differences and development. Brain Res Dev Brain Res 1999; 115: 171-182.
4. Mathieson WB, Taylor SW, Marshall M, Neumann PE. Strain and sex differences in the morphology of the medial preoptic nucleus of mice. J Comp Neurol 2000; 428: 254-265.
5. Robinson SM, Fox TO, Sidman RL. A genetic variant in the morphology of the medial preoptic area in mice. J Neurogenet 1985; 2: 381-388.
6. Dodson RE, Gorski RA. Testosterone propionate administration prevents the loss of neurons within the central part of the medial preoptic nucleus. J Neurobiol 1993; 24: 80-88.
7. Guillamon A, Segovia S, del Abril A. Early effects of gonadal steroids on the neuron number in the medial posterior region and the lateral division of the bed nucleus of the stria terminalis in the rat. Brain Res Dev Brain Res 1988; 44: 281-290.
8. Hines M, Allen LS, Gorski RA. Sex differences in subregions of the medial nucleus of the amygdala and the bed nucleus of the stria terminalis of the rat. Brain Res 1992; 579: 321-326.
9. Bleier R, Byne W, Siggelkow I. Cytoarchitectonic sexual dimorphisms of the medial preoptic and anterior hypothalamic areas in guinea pig, rat, hamster, and mouse. J Comp Neurol 1982; 212: 118-130.
10. Sumida H, Nishizuka M, Kano Y, Arai Y. Sex differences in the anteroventral periventricular nucleus of the preoptic area and in the related effects of androgen in prenatal rats. Neurosci Lett 1993; 151: 41-44.
11. Simerly RB, Swanson LW, Handa RJ, Gorski RA. Influence of perinatal androgen on the sexually dimorphic distribution of tyrosine hydroxylase- immunoreactive cells and fibers in the anteroventral periventricular nucleus of the rat. Neuroendocrinology 1985; 40: 501-510.
12. Bodo C, Kudwa AE, Rissman EF. Both estrogen receptor-alpha and -beta are required for sexual differentiation of the anteroventral periventricular area in mice. Endocrinology 2006; 147: 415-420.
13. Temple JL, Fugger HN, Li X, Shetty SJ, Gustafsson J, Rissman EF. Estrogen receptor beta regulates sexually dimorphic neural responses to estradiol. Endocrinology 2001; 142: 510-513.
14. Bakker J, Baillien M, Honda S, Harada N, Balthazart J. Relationships between aromatase activity in the brain and gonads and behavioural deficits in homozygous and heterozygous aromatase knockout mice. J Neuroendocrinol 2004; 16: 483-490.
15. Fisher CR, Graves KH, Parlow AF, Simpson ER. Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene. Proc Natl Acad Sci USA 1998; 95: 6965-6970.
16. Paxinos G, Franklin KBJ. The Mouse brain in Stereotaxic Coordinates. Elsevier Academic Press: New York, 2001.
17. Hill RA, Pompolo S, Jones ME, Simpson ER, Boon WC. Estrogen deficiency leads to apoptosis in dopaminergic neurons in the medial preoptic area and arcuate nucleus of male mice. Mol Cell Neurosci 2004; 27: 466-476.
18. Mayhew TM. A review of recent advances in stereology for quantifying neural structure. J Neurocytol 1992; 21: 313-328.
19. Simmons DM, Arriza JL, Swanson LW. A complete protocol for in situ hybridization of messenger RNAs' in the brain and other tissues with radiolabeled single-stranded RNA probes. J Histotechn 1989; 12: 169-181.
20. Mitchell V, Lecompte F, Beauvillain JC. Regulation of galanin receptor GalR1 mRNA expression by ovarian steroids in oestrogen receptor alpha-immunoreactive neurones: identification of distinct populations of neurones in the preoptic area. J Neuroendocrinol 2004; 16: 138-145.
21. Bloch GJ, Mills R. Prepubertal testosterone treatment of neonatally gonadectomized male rats: defeminization and masculinization of behavioral and endocrine function in adulthood. Neurosci Biobehav Rev 1995; 19: 187-200.
22. Bloch GJ, Butler PC, Eckersell CB, Mills RH. Gonadal steroid-dependent GAL-IR cells within the medial preoptic nucleus (MPN) and the stimulatory effects of GAL within the MPN on sexual behaviors. Ann NYAcad Sci 1998; 863: 188-205.
23. Robertson KM, Simpson ER, Lacham-Kaplan O, Jones ME. Characterization of the fertility of male aromatase knockout mice. J Androl 2001; 22: 825-830.
24. Arendash GW, Gorski RA. Effects of discrete lesions of the sexually dimorphic nucleus of the preoptic area or other medial preoptic regions on the sexual behavior of male rats. Brain Res Bull 1983; 10: 147-154.
25. Anderson RH, Fleming DE, Rhees RW, Kinghorn E. Relationships between sexual activity, plasma testosterone, and the volume of the sexually dimorphic nucleus of the preoptic area in prenatally stressed and non-stressed rats. Brain Res 1986; 370: 1-10.
26. Hennessey AC, Wallen K, Edwards DA. Preoptic lesions increase the display of lordosis by male rats. Brain Res 1986; 370: 21-28.
27. De Jonge FH, Louwerse AL, Ooms MP, Evers P, Endert E, van de Poll NE. Lesions of the SDN-POA inhibit sexual behavior of male Wistar rats. Brain Res Bull 1989; 23: 483-492.
28. Houtsmuller EJ, Brand T, de Jonge FH, Joosten RN, van de Poll NE, Slob AK. SDN-POA volume, sexual behavior, and partner preference of male rats affected by perinatal treatment with ATD. Physiol Behav 1994; 56: 535-541.
29. Nagao T, Saito Y, Usumi K, Kuwagata M, Imai K. Reproductive function in rats exposed neonatally to bisphenol A and estradiol benzoate. Reprod Toxicol 1999; 13: 303-311.
30. Lephart ED, Call SB, Rhees RW, Jacobson NA, Weber KS, Bledsoe J et al. Neuroendocrine regulation of sexually dimorphic brain structure and associated sexual behavior in male rats is genetically controlled. Biol Reprod 2001; 64: 571-578.
31. Roselli CE, Larkin K, Schrunk JM, Stormshak F. Sexual partner preference, hypothalamic morphology and aromatase in rams. Physiol Behav 2004; 83: 233-245.
32. Turkenburg JL, Swaab DF, Endert E, Louwerse AL, van de Poll NE. Effects of lesions of the sexually dimorphic nucleus on sexual behavior of testosterone-treated female Wister rats. Brain Res Bull 1988; 21: 215-224.
33. Taziaux M, Keller M, Bakker J, Balthazart J. Sexual behavior activity tracks rapid changes in brain estrogen concentrations. J Neurosci 2007; 27: 6563-6572.
34. Bakker J, Honda S, Harada N, Balthazart J. Restoration of male sexual behavior by adult exogenous estrogens in male aromatase knockout mice. Horm Behav 2004; 46: 1-10.
35. Honda S, Harada N, Ito S, Takagi Y, Maeda S. Disruption of sexual behavior in male aromatase-deficient mice lacking exons 1 and 2 of the cyp19 gene. Biochem Biophys Res Commun 1998; 252: 445-449.
36. Sato T, Matsumoto T, Kawano H, Watanabe T, Uematsu Y, Sekine K et al. Brain masculinization requires androgen receptor function. Proc Natl Acad Sci USA 2004; 101: 1673-1678.