Validated method for the simultaneous determination of methadone and its main metabolites (EDDP and EMDP) in plasma of umbilical cord blood by gas chromatography-mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 867, Issue 2, 2008, Pages 219-225

  Nikolaou, Panagiota D ^a,b   Papoutsis, Ioannis I ^a   Atta Politou, Julia ^b   Athanaselis, Sotiris A ^a   Spiliopoulou, Chara A ^a   Calokerinos, Antony C ^b   Maravelias, Constantinos P ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b UNIVERSITY OF ATHENS   (Greece)

Author keywords

EDDP; EMDP; GC MS; Methadone; Umbilical cord blood

Indexed keywords

GAS CHROMATOGRAPHY; MASS SPECTROMETRY; MEDICAL PROBLEMS; PLASMA (HUMAN); PRECIPITATION (CHEMICAL); PROTEINS;

METHADONE; PLASMA SAMPLES; UMBILICAL CORD BLOOD;

METABOLITES;

2 ETHYL 5 METHYL 3,3 DIPHENYLPYRROLINE; 2 ETHYLIDENE 1,5 DIMETHYL 3,3 DIPHENYLPYRROLIDINE; ACETONITRILE; DRUG METABOLITE; METHADONE; PROTEIN;

ACCURACY; ANALYTIC METHOD; ARTERIAL BLOOD; ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG DETERMINATION; DRUG DOSE REDUCTION; HUMAN; INTERDAY ACCURACY; INTRADAY ACCURACY; LIMIT OF DETECTION; LIMIT OF QUANTIFICATION; MAINTENANCE THERAPY; MASS FRAGMENTOGRAPHY; MATERNAL BLOOD; PARAMETER; PLASMA; PRECIPITATION; PREGNANCY; PRENATAL PERIOD; PRIORITY JOURNAL; PUERPERIUM; SENSITIVITY AND SPECIFICITY; SINGLE DRUG DOSE; SOLID PHASE EXTRACTION; STATISTICAL ANALYSIS; UMBILICAL CORD BLOOD; VALIDATION PROCESS; VENOUS BLOOD;

CALIBRATION; FETAL BLOOD; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; METHADONE; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 43549115662     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.04.006     Document Type: Article

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