Improved solid-phase extraction of methadone and its two major metabolites from whole blood

Journal of Analytical Toxicology

Volumn 22, Issue 5, 1998, Pages 389-392

  Cooper, Gail A A ^a   Oliver, John S ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 ETHYL 5 METHYL 3,3 DIPHENYL 1 PYRROLINE; 2 ETHYLIDENE 1,5 DIMETHYL 3,3 DIPHENYLPYRROLIDINE; METHADONE; UNCLASSIFIED DRUG;

ARTICLE; CALIBRATION; DRUG BLOOD LEVEL; DRUG METABOLISM; GAS CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MASS SPECTROMETRY; METHADONE TREATMENT; QUANTITATIVE DIAGNOSIS; SOLID PHASE EXTRACTION;

EID: 0031689142     PISSN: 01464760     EISSN: None     Source Type: Journal    
DOI: 10.1093/jat/22.5.389     Document Type: Article

References (12)

1. G.A.A. Cooper, A. Seymour, J.S. Oliver, and M.T. Cassidy. A study of methadone in fatalities in the Strathclyde Region, 1991-1996. Med. Sci. Law, in press.
2. P. Jacob, III, J.F. Rigod, S.M. Pond, and N.L. Benowitz. Determination of methadone and its primary metabolite in biological fluids using gas chromatography with nitrogen-phosphorus detection. J. Anal. Toxicol. 5: 292-295 (1981).
3. R.K. Lynn, R.M. Leger, W.P. Gordon, G.D. Olsen, and N. Gerber. New gas chromatographic assay for the quantification of methadone: application in human and animal studies. J. Chromatogr. 131: 329-340 (1977).
4. H.B. Greizerstein and I.G. McLaughlin. Sensitive method for the determination of methadone in small blood samples. J. Chromatogr. 264: 312-315 (1983).
5. B.C. Thompson and Y.H. Caplan. A gas chromatographic method for the determination of methadone and its metabolites in biological fluids and tissues. J. Anal. Toxicol. 1: 66-69 (1977).
6. C.E. Inturrisi and K. Verebely. A gas-liquid chromatographic method for the quantitative determination of methadone in human plasma and urine. J. Chromatogr. 65: 361-369 (1972).
7. G. IL Kang and F.S. Abbott. Analysis of methadone and metabolites in biological fluids with gas chromatography-mass spectrometry. J. Chromatogr. 231: 311-319 (1982).
8. M.E. Alburges, W. Huang, R.L. Foltz, and D.E. Moody. Determination of methadone and its N-demethylation metabolites in biological specimens by GC-PICI-MS. J. Anal. Toxicol. 20: 362-368 (1996).
9. D.G. Wilkins, P.R. Nagasawa, S.P. Gygi, R.L. Foltz, and D.E. Rollins. Quantitative analysis of methadone and two major metabolites in hair by positive chemical ionization ion trap mass spectrometry. J. Anal. Toxicol. 20: 355-361 (1996).
10. X.-H. Chen, J.-P. Franke, K. Ensing, J. Wijsbeek, and R.A. de Zeeuw. Pitfalls and solutions in the development of a fully automated solid-phase extraction method for drug screening purposes in plasma and whole blood. J. Anal. Toxicol. 17: 421-426 (1993).
11. P.G.M. Zweipfening, A.H.C.M. Wilderink, P. Horsthuis, J.P. Franke, and R.A. de Zeeuw. Toxicological analysis of whole blood samples by means of Bond-Elut Certify Columns and gas chromatography with nitrogen-phosphorus detection. J. Chromatogr. 674: 87-95 (1994).
12. X.H. Chen, J. Wijsbeek, J.P. Franke, and R.A. de Zeeuw. A single-column procedure on Bond-Elut Certify for systematic toxicological analysis of drugs in plasma and urine. J. Forensic Sci. 37: 61-71 (1992).