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1
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0035141851
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The health economics of asthma and rhinitis. Assessing the economic impact
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Weiss KB, Sullivan SD. The health economics of asthma and rhinitis. Assessing the economic impact. J Allergy Clin Immunol 2001; 107:3-8.
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(2001)
J Allergy Clin Immunol
, vol.107
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Weiss, K.B.1
Sullivan, S.D.2
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2
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0017849188
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Two distinct types of helper T cells involved in the secondary antibody response: Independent and synergistic effects of Ia- and Ia+ helper T cells
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Tada T, Takemori T, Okumura K, et al. Two distinct types of helper T cells involved in the secondary antibody response: independent and synergistic effects of Ia- and Ia+ helper T cells. J Exp Med 1978; 147:446-458.
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J Exp Med
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Tada, T.1
Takemori, T.2
Okumura, K.3
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4
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12344254024
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Regulating the immune system: The induction of regulatory T cells in the periphery
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Buckner JH, Ziegler SF. Regulating the immune system: the induction of regulatory T cells in the periphery. Arthritis Res Ther 2004; 6:215-222.
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(2004)
Arthritis Res Ther
, vol.6
, pp. 215-222
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Buckner, J.H.1
Ziegler, S.F.2
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5
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3042670323
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Altered levels of the soluble IL-1, IL-4, and TNF receptors, as well as the IL-1 receptor antagonist, in intermittent allergic rhinitis
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Benson M, Wennergren G, Frannsson M, Cardell LO. Altered levels of the soluble IL-1, IL-4, and TNF receptors, as well as the IL-1 receptor antagonist, in intermittent allergic rhinitis. Int Arch Allergy Immunol 2004; 134:227-232.
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Int Arch Allergy Immunol
, vol.134
, pp. 227-232
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Benson, M.1
Wennergren, G.2
Frannsson, M.3
Cardell, L.O.4
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7
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34247842880
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Xu G, Mou Z, Jiang H, et al. A possible role of CD4+CD25+ T cells as well as transcription factor FoxP3 in the dysregulation of allergic rhinitis. Laryngoscope 2007; 117:876-880. The present study suggests that decreased expression of FoxP3 in Humans results in impaired and decreased amounts of CD4+CD25+ T-regulatory cells and therefore play a crucial role in immunological imbalance in allergic rhinitis.
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Xu G, Mou Z, Jiang H, et al. A possible role of CD4+CD25+ T cells as well as transcription factor FoxP3 in the dysregulation of allergic rhinitis. Laryngoscope 2007; 117:876-880. The present study suggests that decreased expression of FoxP3 in Humans results in impaired and decreased amounts of CD4+CD25+ T-regulatory cells and therefore play a crucial role in immunological imbalance in allergic rhinitis.
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8
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33847624061
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Lee JH, Yu HH, Wang LC, et al. The levels of CD4+CD25+ regulatory T cells in pediatric patients with allergic rhinitis and bronchial asthma. Clin Exp Immunol 2007; 148:53-63. The present study elucidated the correlation of severity of allergic rhinitis and asthma with the expression of FoxP3 and CD4+CD25+ T-regulatory cells.
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Lee JH, Yu HH, Wang LC, et al. The levels of CD4+CD25+ regulatory T cells in pediatric patients with allergic rhinitis and bronchial asthma. Clin Exp Immunol 2007; 148:53-63. The present study elucidated the correlation of severity of allergic rhinitis and asthma with the expression of FoxP3 and CD4+CD25+ T-regulatory cells.
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9
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15244344608
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Robinson DS, Larche M, Durham SR. Tregs and allergic disease. J Clin Invest 2004; 114:1389-1397.
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Robinson DS, Larche M, Durham SR. Tregs and allergic disease. J Clin Invest 2004; 114:1389-1397.
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10
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0035163909
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X-linked neonatal diabetes mellitus, enteropathy, and endocrinopathy syndrome is human equivalent of mouse scurfy
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Wilden RS, Ramsdell F, Peake J, et al. X-linked neonatal diabetes mellitus, enteropathy, and endocrinopathy syndrome is human equivalent of mouse scurfy. Nat Genet 2001; 27:18-20.
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(2001)
Nat Genet
, vol.27
, pp. 18-20
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Wilden, R.S.1
Ramsdell, F.2
Peake, J.3
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11
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0035167967
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The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutation of FoxP3
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Bennett CL, Christie J, Ramsdell F, et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutation of FoxP3. Nat Genet 2001; 27:20-21.
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(2001)
Nat Genet
, vol.27
, pp. 20-21
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Bennett, C.L.1
Christie, J.2
Ramsdell, F.3
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12
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34247862225
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Severe food allergy as a variant of IPEX syndrome caused by a deletion in a noncoding region of the FoxP3 gene
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Torgerson TR, Linane A, Moes N, et al. Severe food allergy as a variant of IPEX syndrome caused by a deletion in a noncoding region of the FoxP3 gene. Gastroenterology 2007; 132:1705-1717.
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(2007)
Gastroenterology
, vol.132
, pp. 1705-1717
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Torgerson, T.R.1
Linane, A.2
Moes, N.3
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13
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34247215187
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FoxP3 controls regulatory T-cell function by interacting with AML1/Runx1
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The present study showed the interaction of AML1/Runx1 with FoxP3 resulting in Treg cell upregulation and suppression of IFN-γ
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Ono MY, Yaguchi H, Ohkura N, et al. FoxP3 controls regulatory T-cell function by interacting with AML1/Runx1. Nature 2007; 446:685-689. The present study showed the interaction of AML1/Runx1 with FoxP3 resulting in Treg cell upregulation and suppression of IFN-γ.
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(2007)
Nature
, vol.446
, pp. 685-689
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Ono, M.Y.1
Yaguchi, H.2
Ohkura, N.3
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15
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2442484053
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Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses
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Sakaguchi S. Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 2004; 22:531-562.
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(2004)
Annu Rev Immunol
, vol.22
, pp. 531-562
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Sakaguchi, S.1
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16
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0037364804
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Natural versus adaptive regulatory T cells
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Bluestone JA, Abbas AK. Natural versus adaptive regulatory T cells. Nat Rev Immunol 2003; 3:253-257.
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(2003)
Nat Rev Immunol
, vol.3
, pp. 253-257
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Bluestone, J.A.1
Abbas, A.K.2
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17
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16844363097
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A well adapted regulatory contrivance: The forkhead family transcription factor Foxp3 and regulatory T cell development
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Fontenot JD, Rudensky A. A well adapted regulatory contrivance: the forkhead family transcription factor Foxp3 and regulatory T cell development. Nat Immunol 2005; 6:331-337.
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(2005)
Nat Immunol
, vol.6
, pp. 331-337
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Fontenot, J.D.1
Rudensky, A.2
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18
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34548699169
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Demonstration of circulating allergen-specific CD4+CD25(high)FoxP3+ T-regulatory cells in both nonatopic and atopic individuals
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The present study shows CD4+25+FoxP3+ cells are capable of recognizing specific exogenous ubiquitous antigens in both atopic and nonatopic individuals
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Maggi L, Santarlasci V, Liotta F, et al. Demonstration of circulating allergen-specific CD4+CD25(high)FoxP3+ T-regulatory cells in both nonatopic and atopic individuals. J Allergy Clin Immunol 2007; 120:429-436. The present study shows CD4+25+FoxP3+ cells are capable of recognizing specific exogenous ubiquitous antigens in both atopic and nonatopic individuals.
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(2007)
J Allergy Clin Immunol
, vol.120
, pp. 429-436
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Maggi, L.1
Santarlasci, V.2
Liotta, F.3
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19
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34247526094
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Hartl D, Koller B, Mehlhorn AT, et al. Quantitative and functional impairment of pulmonary CD4+CD25(high) regulatory T cells in pediatric asthma. J Allergy Clin Immunol 2007; 119:1258-1266. The present study shows a decrease in the number of CD4+CD25+ T-regulatory cells in BALF of children with asthma. Additionally, the use of inhaled corticosteroids allowed for the CD4+CD25+ T-regulatory cells to become functional, indicating a therapeutic mechanism for further research.
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Hartl D, Koller B, Mehlhorn AT, et al. Quantitative and functional impairment of pulmonary CD4+CD25(high) regulatory T cells in pediatric asthma. J Allergy Clin Immunol 2007; 119:1258-1266. The present study shows a decrease in the number of CD4+CD25+ T-regulatory cells in BALF of children with asthma. Additionally, the use of inhaled corticosteroids allowed for the CD4+CD25+ T-regulatory cells to become functional, indicating a therapeutic mechanism for further research.
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20
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2942685507
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Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells
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Akdis M, Verhagen J, Taylor A. Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J Exp Med 2004; 199:1567-1575.
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(2004)
J Exp Med
, vol.199
, pp. 1567-1575
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Akdis, M.1
Verhagen, J.2
Taylor, A.3
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21
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4644227859
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Regulatory CD4+CD25+ T lymphocytes in peripheral blood from patients with atopic asthma
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Shi HZ, Li S, Xie ZF, et al. Regulatory CD4+CD25+ T lymphocytes in peripheral blood from patients with atopic asthma. J Allergy Clin Immunol 2004; 113:172-178.
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(2004)
J Allergy Clin Immunol
, vol.113
, pp. 172-178
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Shi, H.Z.1
Li, S.2
Xie, Z.F.3
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22
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1342308180
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Relation of CD4CD25 regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease
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Ling EM, Smith T, Nguyen XD, et al. Relation of CD4CD25 regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease. Lancet 2004; 363:608-615.
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(2004)
Lancet
, vol.363
, pp. 608-615
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Ling, E.M.1
Smith, T.2
Nguyen, X.D.3
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23
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4544256262
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Defective suppression of Th2 cytokines by CD4CD25 regulatory T cells in birch allergics during birch pollen season
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Grindebacke H, Wing K, Andersson AC, et al. Defective suppression of Th2 cytokines by CD4CD25 regulatory T cells in birch allergics during birch pollen season. Clin Exp Allergy 2004; 34:1364-1372.
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(2004)
Clin Exp Allergy
, vol.34
, pp. 1364-1372
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Grindebacke, H.1
Wing, K.2
Andersson, A.C.3
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24
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34250180480
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Histamine 4 receptor activation induces recruitment of FoxP3+ T cells and inhibits allergic asthma in a murine model
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The present study reveals possible future therapeutic approach to treatment of allergic asthma via target of histamine receptors yielding CD4+CD25+ Treg cell recruitment and decreased airway inflammation
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Morgan RK, McAllister B, Cross L, et al. Histamine 4 receptor activation induces recruitment of FoxP3+ T cells and inhibits allergic asthma in a murine model. J Immunol 2007; 178:8081-8089. The present study reveals possible future therapeutic approach to treatment of allergic asthma via target of histamine receptors yielding CD4+CD25+ Treg cell recruitment and decreased airway inflammation.
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(2007)
J Immunol
, vol.178
, pp. 8081-8089
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Morgan, R.K.1
McAllister, B.2
Cross, L.3
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25
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38349096223
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Expansion of circulating FoxP3+CD25bright CD4+ T cells during specific venom immunotherapy
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Pereira-Santos MC, Baptiest AP, Melo A, et al. Expansion of circulating FoxP3+CD25bright CD4+ T cells during specific venom immunotherapy. Clin Exp Allergy 2008; 38:291-297.
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(2008)
Clin Exp Allergy
, vol.38
, pp. 291-297
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Pereira-Santos, M.C.1
Baptiest, A.P.2
Melo, A.3
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26
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34247644785
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Prolonged inhaled allergen exposure can induce persistent tolerance
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The present study utilizing the murine model compares Treg cell numbers during sensitization and tolerance in allergic airway inflammation
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Van Hove CL, Maes T, Joos GF, Tournoy KG. Prolonged inhaled allergen exposure can induce persistent tolerance. Am J Respir Cell Mol Biol 2007; 36:573-584. The present study utilizing the murine model compares Treg cell numbers during sensitization and tolerance in allergic airway inflammation.
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(2007)
Am J Respir Cell Mol Biol
, vol.36
, pp. 573-584
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Van Hove, C.L.1
Maes, T.2
Joos, G.F.3
Tournoy, K.G.4
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27
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3242754344
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Tolerance induced by inhaled antigen involves CD4+ T cells expressing membrane-bound TGF-β and FoxP3
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Troukhova M, Seguin-Devaux C, Oris TB, et al. Tolerance induced by inhaled antigen involves CD4+ T cells expressing membrane-bound TGF-β and FoxP3. J Clin Invest 2005; 114:28-38.
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J Clin Invest
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Troukhova, M.1
Seguin-Devaux, C.2
Oris, T.B.3
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28
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38149057181
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Suppression of allergic inflammation by allergen-DNA-modified dendritic cells depends on the induction of FoxP3+ regulatory T cells
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Wu K, Bi Y, Sun K, et al. Suppression of allergic inflammation by allergen-DNA-modified dendritic cells depends on the induction of FoxP3+ regulatory T cells. Scand J Immunol 2008; 67:140-151.
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Scand J Immunol
, vol.67
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Wu, K.1
Bi, Y.2
Sun, K.3
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29
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34447572925
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Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells
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The present study indicates another possible therapeutic target for treatment of asthma in the future
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Finotto S, Eigenbrod T, Karwot R, et al. Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells. Int Immunol 2007; 19:685-693. The present study indicates another possible therapeutic target for treatment of asthma in the future.
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(2007)
Int Immunol
, vol.19
, pp. 685-693
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Finotto, S.1
Eigenbrod, T.2
Karwot, R.3
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30
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0348223787
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Conversion of peripheral CD4+25- naïve T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor FoxP3
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Chen W, Jin W, Hardegen N, et al. Conversion of peripheral CD4+25- naïve T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor FoxP3. J Exp Med 2003; 198:1875-1886.
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J Exp Med
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, pp. 1875-1886
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Chen, W.1
Jin, W.2
Hardegen, N.3
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