Syntaxin 8 has two functionally distinct di-leucine-based motifs

Cellular and Molecular Biology Letters

Volumn 13, Issue 1, 2008, Pages 144-154

  Kasai, Kazuo ^a,b,c   Suga, Kei ^a   Izumi, Tetsuro ^c   Akagawa, Kimio ^a  

^a KYORIN UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOYAMA CHEMICAL CO LTD   (Japan)

^c GUNMA UNIVERSITY   (Japan)

Author keywords

Di leucine based motif; Endocytosis; Exocytosis; Syntaxin

Indexed keywords

LEUCINE; SYNTAXIN; SYNTAXIN 7; SYNTAXIN 8;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CELL MIGRATION; CONTROLLED STUDY; CYTOPLASM; ENDOCYTOSIS; EXOCYTOSIS; MUTATION; NONHUMAN; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; TRANSPORT KINETICS;

EID: 43549097811     PISSN: 14258153     EISSN: 16891392     Source Type: Journal    
DOI: 10.2478/s11658-007-0043-9     Document Type: Article

References (37)

1. Palade, G. Intracellular aspects of the process of protein synthesis. Science189 (1975) 347–358.
2. Pryer, N.K., Wuestehube, L.J. and Schekman, R. Vesicle-mediated protein sorting. Annu. Rev. Biochem.61 (1992) 471–516.
3. Rothman, J.E. and Warren, G. Implications of the SNARE hypothesis for intracellular membrane topology and dynamics. Curr. Biol.4 (1994) 220–233.
4. Rothman, J.E. and Wieland, F.T. Protein sorting by transport vesicles. Science272 (1996) 227–234.
5. Schekman, R. and Orci, L. Coat proteins and vesicle budding. Science271 (1996) 1526–1533.
6. Clary, D.O., Griff, I.C. and Rothman, J.E. SNAPs, a family of NSF attachment proteins involved in intracellular membrane fusion in animals and yeast. Cell61 (1990) 709–721.
7. Graham, T.R. and Emr, S.D. Compartmental organization of Golgi-specific protein modification and vacuolar protein sorting events defined in a yeast sec18 (NSF) mutant. J. Cell Biol.114 (1991) 207–218.
8. Griff, I.C., Schekman, R., Rothman, J.E. and Kaiser, C.A. The yeast SEC17 gene product is functionally equivalent to mammalian alpha-SNAP protein. J. Biol. Chem.267 (1992) 12106–12115.
9. Bennett, M.K. and Scheller, R.H. The molecular machinery for secretion is conserved from yeast to neurons. Proc. Natl. Acad. Sci. USA90 (1993) 2559–2563.
10. Söllner, T., Bennett, M.K., Whiteheart, S.W., Scheller, R.H. and Rothman, J.E. A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion. Cell75 (1993) 409–418.
11. Söllner, T., Whiteheart, S.W., Brunner, M., Erdjument-Bromage, H., Geromanos, S., Tempst, P. and Rothman, J.E. SNAP receptors implicated in vesicle targeting and fusion. Nature362 (1993) 318–324.
12. McNew, J.A., Parlati, F., Fukuda, R., Johnston, R.J., Paz, K., Paumet, F., Söllner, T.H. and Rothman, J.E. Compartmental specificity of cellular membrane fusion encoded in SNARE proteins. Nature407 (2000) 153–159.
13. Parlati, F., McNew, J.A., Fukuda, R., Miller, R., Söllner, T.H. and Rothman, J.E. Topological restriction of SNARE-dependent membrane fusion. Nature407 (2000) 194–198.
14. Fukuda, R., McNew, J. A., Weber, T., Parlati, F., Engel, T., Nickel, W., Rothman, J.E. and Söllner, T.H. Functional architecture of an intracellular membrane t-SNARE. Nature407 (2000) 198–202.
15. Trowbridge, I.S., Collawn, J.F. and Hopkins, C.R. Signal-dependent membrane protein trafficking in the endocytic pathway. Annu. Rev. Cell Biol.9 (1993) 129–161.
16. Sandoval, I.V. and Bakke, O. Targeting of membrane proteins to endosomes and lysosomes. Trends Cell Biol.4 (1994) 292–297.
17. Letourner, F. and Klausner, R.D. A novel di-leucine motif and a tyrosinebased motif independently mediate lysosomal targeting and endocytosis of CD3 chains. Cell69 (1992) 1143–1157.
18. Bremnes, B., Madsen, T., Gedde-Dahl, M. and Bakke, O. A LI and ML motif in the cytoplasmic tail of MHC-associated invariant chain mediate rapid internalization. J. Cell Sci.107 (1994) 2021–2032.
19. Pond, L., Kuhn, L., Teyton, L., Schutze, M.P., Tainer, J.A., Jackson, M.R. and Peterson, P.A. A role for acidic residues in di-leucine motif-based targeting to the endocytic pathway. J. Biol. Chem.270 (1995) 19989–19997.
20. Simmen, T., Schmidt, A., Hunziker, W. and Beermann, F. The tyrosinase tail mediates sorting to the lysosomal compartment in MDCK cells via a dileucine and tyrosine-based signal. J. Cell Sci.112 (1999) 45–53.
21. Li, Y., Marzolo, M.P., Van Kerkhof, P., Strous, G.J. and Bu, G. The YXXL motif, but not the two NPXY motifs, serves as the dominant endocytosis signal for low density lipoprotein receptor-related protein. J. Biol. Chem.275 (2000) 17187–17194.
22. Johnson, K. and Kornfeld, S. The cytoplasmic tail of the mannose 6-phosphate/insulin-like growth factor-II receptor has two signals for lysosomal enzyme sorting in the Golgi. J. Cell Biol.119 (1992) 249–257.
23. Wong, S.H., Xu, Y., Zhang, T. and Hong, W. Syntaxin 7, a novel syntaxin member associated with the early endosomal compartment. J. Biol. Chem.273 (1998) 375–380.
24. Nakamura, N., Yamamoto, A., Wada, Y. and Futai, M. Syntaxin 7 mediates endocytic trafficking to late endosomes. J. Biol. Chem.275 (2000) 6523–6529.
25. Prekeris, R., Yang, B., Oorschot, V., Klumperman, J. and Scheller, R.H. Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking. Mol. Biol. Cell10 (1999) 3891–3908.
26. Subramaniam, V.N., Loh, E., Horstmann, H., Habermann, A., Xu, Y., Coe, J., Griffiths, G. and Hong, W. Preferential association of syntaxin 8 with the early endosome. J. Cell Sci.113 (2000) 997–1008.
27. Antonin, W., Holroyd, C., Fasshauer, D., Pabst, S., Von Mollard, G.F. and Jahn, R. A SNARE complex mediating fusion of late endosomes defines conserved propaties of SNARE structure and function. EMBO J.19 (2000) 6453–6464
28. Kasai, K. and Akagawa, K. Roles of the cytoplasmic and transmembrane domains of syntaxins in intracellular localization and trafficking. J. Cell Sci.114 (2001) 3115–3124.
29. Shin, H.W., Shinotsuka, C., Torii, S., Murakami, K. and Nakayama, K. Identification and subcellular localization of a novel mammalian dynamin-related protein homologous to yeast Vps1p and Dnm1p. J. Biochem. (Tokyo)122 (1997) 525–530.
30. Torii, S., Banno, T., Watanabe, T., Ikehara, Y., Murakami, K. and Nakayama, K. Cytotoxicity of brefeldin A correlates with its inhibitory effect on membrane binding of COP coat proteins. J. Biol. Chem.270 (1995) 11574–11580.
31. Thoreau, V., Bergès, T., Callebaut, I., Guillier-Gencik, Z., Gressin, L., Bernheim, A., Karst, F., Mornon, J.P., Kitzis, A. and Chomel, J.C. Molecular cloning, expression analysis, and chromosomal localization of human syntaxin 8 (STX8). Biochem. Biophys. Res. Commun.257 (1999) 577–583.
32. Hong, W. SNAREs and traffic. Biochim. Biophys. Acta1744 (2005) 465–517.
33. Heilker, R., Manning-Krieg, U., Zuber, J.F. and Spiess, M. In vitro binding of clathrin adaptors to sorting signals correlates with endocytosis and basolateral sorting. EMBO J.15 (1996) 2893–2899.
34. Darsow, T., Burd, C.G. and Emr, S.D. Acidic di-leucine motif essential for AP-3-dependent sorting and restriction of the functional specificity of the Vam3p vacuolar t-SNARE. J. Cell Biol.142 (1998) 913–922.
35. Höning, S., Sandoval, I.V. and Von Figura, K.A. Di-leucine-based motif in the cytoplasmic tail of LIMP-II and tyrosinase mediates selective binding of AP-3. EMBO J.17 (1998) 1304–1314.
36. Pearse, B.M. and Robinson, M.S. Clathrin, adaptors, and sorting. Annu. Rev. Cell Biol.6 (1990) 151–171.
37. Chao, D.S., Hay, J.C., Winnick, S., Prekeris, R., Klumperman, J. and Scheller, R.H. SNARE membrane trafficking dynamics in vivo. J. Cell Biol.144 (1999) 869–881.