Galectin-3 regulates RasGRP4-mediated activation of N-Ras and H-Ras

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1783, Issue 6, 2008, Pages 985-993

  Shalom Feuerstein, Ruby ^a   Levy, Ran ^a   Makovski, Victoria ^a   Raz, Avraham ^b   Kloog, Yoel ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b WAYNE STATE UNIVERSITY   (United States)

Author keywords

Cancer; Galectin 3; Ras; RasGRP4

Indexed keywords

EPIDERMAL GROWTH FACTOR; GALECTIN 3; K RAS PROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN; RAS GUANINE NUCLEOTIDE RELEASING PROTEIN; SHORT HAIRPIN RNA;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL GROWTH; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; GENE ACTIVATION; GLIOBLASTOMA; HUMAN; HUMAN CELL; NONHUMAN; ONCOGENE H RAS; ONCOGENE N RAS; OVARY CARCINOMA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION;

ANIMALS; BLOTTING, WESTERN; CRICETINAE; EPIDERMAL GROWTH FACTOR; GALECTIN 3; GENES, RAS; GUANOSINE TRIPHOSPHATE; HUMANS; IMMUNOPRECIPITATION; NEOPLASMS; RAS GUANINE NUCLEOTIDE EXCHANGE FACTORS; RAS PROTEINS; RATS; RNA, SMALL INTERFERING; TETRADECANOYLPHORBOL ACETATE; TUMOR CELLS, CULTURED;

EID: 43549094660     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2008.03.009     Document Type: Article

References (38)

1. Boriack-Sjodin P.A., Margarit S.M., Bar-Sagi D., and Kuriyan J. The structural basis of the activation of Ras by Sos. Nature 394 (1998) 337-343
2. Mitin N., Rossman K.L., and Der C.J. Signaling interplay in Ras superfamily function. Curr. Biol. 15 (2005) R563-R574
3. Quilliam L.A., Rebhun J.F., and Castro A.F. A growing family of guanine nucleotide exchange factors is responsible for activation of Ras-family GTPases. Prog. Nucleic Acid Res. Mol. Biol. 71 (2002) 391-444
4. Boguski M.S., and McCormick F. Proteins regulating Ras and its relatives. Nature 366 (1993) 643-654
5. Barbacid M. ras oncogenes: their role in neoplasia. Eur. J. Clin. Investig. 20 (1990) 225-235
6. Shields J.M., Pruitt K., McFall A., Shaub A., and Der C.J. Understanding Ras: 'it ain't over 'til it's over'. Trends Cell Biol. 10 (2000) 147-154
7. Philips M.R. Compartmentalized signalling of Ras. Biochem. Soc. Trans. 33 (2005) 657-661
8. Plowman S.J., and Hancock J.F. Ras signaling from plasma membrane and endomembrane microdomains. Biochim. Biophys. Acta 1746 (2005) 274-283
9. Paz A., Haklai R., Elad-Sfadia G., Ballan E., and Kloog Y. Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anchorage and cell transformation. Oncogene 20 (2001) 7486-7493
10. Elad-Sfadia G., Haklai R., Ballan E., Gabius H.J., and Kloog Y. Galectin-1 augments Ras activation and diverts Ras signals to Raf-1 at the expense of phosphoinositide 3-kinase. J. Biol. Chem. 277 (2002) 37169-37175
11. Rotblat B., Niv H., Andre S., Kaltner H., Gabius H.J., and Kloog Y. Galectin-1(L11A) predicted from a computed galectin-1 farnesyl-binding pocket selectively inhibits Ras-GTP. Cancer Res. 64 (2004) 3112-3118
12. Shalom-Feuerstein R., Cooks T., Raz A., and Kloog Y. Galectin-3 regulates a molecular switch from N-Ras to K-Ras usage in human breast carcinoma cells. Cancer Res. 65 (2005) 7292-7300
13. Elad-Sfadia G., Haklai R., Balan E., and Kloog Y. Galectin-3 augments K-Ras activation and triggers a Ras signal that attenuates ERK but not phosphoinositide 3-kinase activity. J. Biol. Chem. 279 (2004) 34922-34930
14. Takenaka Y., Fukumori T., and Raz A. Galectin-3 and metastasis. Glycoconj. J. 19 (2004) 543-549
15. Nakahara S., and Raz A. On the role of galectins in signal transduction. Methods Enzymol. 417 (2006) 273-289
16. Barbacid M. ras genes. Ann. Rev. Biochem. 56 (1987) 779-827
17. Bos J.L. p21ras: an oncoprotein functioning in growth factor-induced signal transduction. Eur. J. Cancer 31 (1995) 1051-1054
18. Barondes S.H., Cooper D.N., Gitt M.A., and Leffler H. Galectins. Structure and function of a large family of animal lectins. J. Biol. Chem. 269 (1994) 20807-20810
19. Gong H.C., Honjo Y., Nangia-Makker P., Hogan V., Mazurak N., Bresalier R.S., and Raz A. The NH2 terminus of galectin-3 governs cellular compartmentalization and functions in cancer cells. Cancer Res. 59 (1999) 6239-6245
20. Perillo N.L., Marcus M.E., and Baum L.G. Galectins: versatile modulators of cell adhesion, cell proliferation, and cell death. J. Mol. Med. 76 (1998) 402-412
21. Liu F.T., Patterson R.J., and Wang J.L. Intracellular functions of galectins. Biochim. Biophys. Acta 1572 (2002) 263-273
22. Moisa A., Fritz P., Eck A., Wehner H.D., Murdter T., Simon W., and Gabius H.J. Growth/adhesion-regulatory tissue lectin galectin-3: stromal presence but not cytoplasmic/nuclear expression in tumor cells as a negative prognostic factor in breast cancer. Anticancer Res. 27 (2007) 2131-2139
23. Delacour D., Greb C., Koch A., Salomonsson E., Leffler H., Le Bivic A., and Jacob R. Apical sorting by galectin-3-dependent glycoprotein clustering. Traffic 8 (2007) 379-388
24. Yu F., Finley Jr. R.L., Raz A., and Kim H.R. Galectin-3 translocates to the perinuclear membranes and inhibits cytochrome c release from the mitochondria. A role for synexin in galectin-3 translocation. J. Biol. Chem. 277 (2002) 15819-15827
25. Ashery U., Yizhar O., Rotblat B., Elad-Sfadia G., Barkan B., Haklai R., and Kloog Y. Spatiotemporal organization of ras signaling: rasosomes and the galectin switch. Cell. Mol. Neurobiol. 26 (2006) 469-493
26. Niv H., Gutman O., Kloog Y., and Henis Y.I. Activated K-Ras and H-Ras display different interactions with saturable nonraft sites at the surface of live cells. J. Cell Biol. 157 (2002) 865-872
27. Reuther G.W., Lambert Q.T., Rebhun J.F., Caligiuri M.A., Quilliam L.A., and Der C.J. RasGRP4 is a novel Ras activator isolated from acute myeloid leukemia. J. Biol. Chem. 277 (2002) 30508-30514
28. Shalom-Feuerstein R., Lindenboim L., Stein R., Cox A.D., and Kloog Y. Restoration of sensitivity to anoikis in Ras-transformed rat intestinal epithelial cells by a Ras inhibitor. Cell Death Differ. 11 (2004) 244-247
29. Hebert E., and Monsigny M. Galectin-3 mRNA level depends on transformation phenotype in ras-transformed NIH 3T3 cells. Biol. Cell 81 (1994) 73-76
30. Yoshii T., Fukumori T., Honjo Y., Inohara H., Kim H.R., and Raz A. Galectin-3 phosphorylation is required for its anti-apoptotic function and cell cycle arrest. J. Biol. Chem. 277 (2002) 6852-6857
31. Takenaka Y., Inohara H., Yoshii T., Oshima K., Nakahara S., Akahani S., Honjo Y., Yamamoto Y., Raz A., and Kubo T. Malignant transformation of thyroid follicular cells by galectin-3. Cancer Lett. 195 (2003) 111-119
32. Liao J., Planchon S.M., Wolfman J.C., and Wolfman A. Growth factor-dependent AKT activation and cell migration requires the function of c-K(B)-Ras versus other cellular ras isoforms. J. Biol. Chem. 281 (2006) 29730-29738
33. Voice J.K., Klemke R.L., Le A., and Jackson J.H. Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility. J. Biol. Chem. 274 (1999) 17164-17170
34. Keller J.W., Haigis K.M., Franklin J.L., Whitehead R.H., Jacks T., and Coffey R.J. Oncogenic K-RAS subverts the antiapoptotic role of N-RAS and alters modulation of the N-RAS:gelsolin complex. Oncogene 26 (2007) 3051-3059
35. Bivona T.G., Quatela S.E., Bodemann B.O., Ahearn I.M., Soskis M.J., Mor A., Miura J., Wiener H.H., Wright L., Saba S.G., Yim D., Fein A., Perez de Castro I., Li C., Thompson C.B., Cox A.D., and Philips M.R. PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis. Mol. Cell 21 (2006) 481-493
36. Bivona T.G., Perez De Castro I., Ahearn I.M., Grana T.M., Chiu V.K., Lockyer P.J., Cullen P.J., Pellicer A., Cox A.D., and Philips M.R. Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1. Nature 424 (2003) 694-698
37. Yang Y., Li L., Wong G.W., Krilis S.A., Madhusudhan M.S., Sali A., and Stevens R.L. RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function. J. Biol. Chem. 277 (2002) 25756-25774
38. Chen H.Y., Sharma B.B., Yu L., Zuberi R., Weng I.C., Kawakami Y., Kawakami T., Hsu D.K., and Liu F.T. Role of galectin-3 in mast cell functions: galectin-3-deficient mast cells exhibit impaired mediator release and defective JNK expression. J. Immunol. 177 (2006) 4991-4997