Molecular and cytogenetic characterization of plexiform leiomyomata provide further evidence for genetic heterogeneity underlying uterine fibroids

American Journal of Pathology

Volumn 172, Issue 5, 2008, Pages 1403-1410

  Hodge, Jennelle C ^a,b   Quade, Bradley J ^a,b   Rubin, Mark A ^a,b   Stewart, Elizabeth A ^a   Cin, Paola Dal ^a,b   Morton, Cynthia C ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH MOBILITY GROUP A2 PROTEIN; MESSENGER RNA;

ARTICLE; CYTOGENETICS; FLUORESCENCE IN SITU HYBRIDIZATION; GENETIC HETEROGENEITY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KARYOTYPE; LEIOMYOBLASTOMA; LEIOMYOSARCOMA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; UTERUS MYOMA;

EID: 43449112674     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.2353/ajpath.2008.071102     Document Type: Article

References (42)

1. SF Cramer A Patel The frequency of uterine leiomyomas Am J Clin Pathol 94 1990 435 438
2. MS Rein RA Nowak Biology of uterine myomas and myometrium in vitro Semin Reprod Endocrinol 10 1992 310 319
3. GD Coronado LM Marshall SM Schwartz Complications in pregnancy, labor, and delivery with uterine leiomyomas: a population-based study Obstet Gynecol 95 2000 764 769
4. KE Hartmann H Birnbaum R Ben-Hamadi EQ Wu MH Farrell J Spalding P Stang Annual costs associated with diagnosis of uterine leiomyomata Obstet Gynecol 108 2006 930 937
5. LA Lepine SD Hillis PA Marchbanks LM Koonin B Morrow BA Kieke LS Wilcox Hysterectomy surveillance—United States, 1980–1993 MMWR CDC Surveill Summ 46 1997 1 15
6. M Flynn M Jamison S Datta E Myers Health care resource use for uterine fibroid tumors in the United States Am J Obstet Gynecol 195 2006 955 964
7. M Nibert S Heim Uterine leiomyoma cytogenetics Genes Chromosom Cancer 2 1990 3 13
8. MS Rein AJ Friedman RL Barbieri K Pavelka JA Fletcher CC Morton Cytogenetic abnormalities in uterine leiomyomata Obstet Gynecol 77 1991 923 926
9. AM Meloni U Surti AM Contento J Davare AA Sandberg Uterine leiomyomas: cytogenetic and histologic profile Obstet Gynecol 80 1992 209 217
10. KL Gross DM Neskey N Manchanda S Weremowicz MS Kleinman RA Nowak AH Ligon P Rogalla K Drechsler J Bullerdiek CC Morton HMGA2 expression in uterine leiomyomata and myometrium: quantitative analysis and tissue culture studies Genes Chromosom Cancer 38 2003 68 79
11. M Schoenberg Fejzo HR Ashar KS Krauter WL Powell MS Rein S Weremowicz SJ Yoon RS Kucherlapati K Chada CC Morton Translocation breakpoints upstream of the HMGIC gene in uterine leiomyomata suggest dysregulation of this gene by a mechanism different from that in lipomas Genes Chromosom Cancer 17 1996 1 6
12. EF Schoenmakers S Wanschura R Mols J Bullerdiek H Van den Berghe WJ Van de Ven Recurrent rearrangements in the high mobility group protein gene. HMGI-C, in benign mesenchymal tumours Nat Genet 10 1995 436 444
13. R Grosschedl K Giese J Pagel HMG domain proteins: architectural elements in the assembly of nucleoprotein structures Trends Genet 10 1994 94 100
14. AP Wolffe Architectural transcription factors Science 264 1994 1100 1101
15. R Reeves Molecular biology of HMGA proteins: hubs of nuclear function Gene 277 2001 63 81
16. AH Ligon SD Moore MA Parisi ME Mealiffe DJ Harris HL Ferguson BJ Quade CC Morton Constitutional rearrangement of the architectural factor HMGA2: a novel human phenotype including overgrowth and lipomas Am J Hum Genet 76 2005 340 348
17. MN Weedon G Lettre RM Freathy CM Lindgren BF Voight JR Perry KS Elliott R Hackett C Guiducci B Shields E Zeggini H Lango V Lyssenko NJ Timpson NP Burtt NW Rayner R Saxena K Ardlie JH Tobias AR Ness SM Ring CN Palmer AD Morris L Peltonen V Salomaa GD Smith LC Groop AT Hattersley MI McCarthy JN Hirschhorn TM Frayling A common variant of HMGA2 is associated with adult and childhood height in the general population Nat Genet 39 2007 1245 1250
18. MR Nucci BJ Quade Uterine mesenchymal tumors, chapter 20 CP Crum KR Lee Diagnostic Gynecologic and Obstetric Pathology 2005 Elsevier Saunders Frankfurt
19. RJ Kurman HJ Norris Mesenchymal tumors of the uterus. VI. Epithelioid smooth muscle tumors including leiomyoblastoma and clear-cell leiomyoma: a clinical and pathologic analysis of 26 cases Cancer 37 1976 1853 1865
20. P Lavin SI Hajdu FW Foote Jr Gastric and extragastric leiomyoblastomas: clinicopathologic study of 44 cases Cancer 29 1972 305 311
21. AP Kyriazis AA Kyriazis Uterine leiomyoblastoma (epithelioid leiomyoma) neoplasm of low-grade malignancy. A histopathologic study Arch Pathol Lab Med 116 1992 1189 1191
22. HL Evans SP Chawla C Simpson KP Finn Smooth muscle neoplasms of the uterus other than ordinary leiomyoma. A study of 46 cases, with emphasis on diagnostic criteria and prognostic factors Cancer 62 1988 2239 2247
23. MT Mazur FT Kraus Histogenesis of morphologic variations in tumors of the uterine wall Am J Surg Pathol 4 1980 59 74
24. H Nagel U Brinck D Luthje L Fuzesi Plexiform leiomyoma of the uterus in a patient with breast carcinoma: case report and review of the literature Pathology 31 1999 292 294
25. PF Kaminski FA Tavassoli Plexiform tumorlet: a clinical and pathologic study of 15 cases with ultrastructural observations Int J Gynecol Pathol 3 1984 124 134
26. JD Seidman RM Thomas Multiple plexiform tumorlets of the uterus Arch Pathol Lab Med 117 1993 1255 1256
27. WW Goodhue M Susin EE Kramer Smooth muscle origin of uterine plexiform tumors Arch Pathol 97 1974 263 268
28. C Nunez-Alonso HA Battifora Plexiform tumors of the uterus: ultrastructural study Cancer 44 1979 1707 1714
29. ER Fisher JD Paulson RM Gregorio The myofibroblastic nature of the uterine plexiform tumor Arch Pathol Lab Med 102 1978 477 480
30. VG Cheung N Nowak W Jang IR Kirsch S Zhao XN Chen TS Furey UJ Kim WL Kuo M Olivier J Conroy A Kasprzyk H Massa R Yonescu S Sait C Thoreen A Snijders E Lemyre JA Bailey A Bruzel WD Burrill SM Clegg S Collins P Dhami C Friedman CS Han S Herrick J Lee AH Ligon S Lowry M Morley S Narasimhan K Osoegawa Z Peng I Plajzer-Frick BJ Quade D Scott K Sirotkin AA Thorpe JW Gray J Hudson D Pinkel T Ried L Rowen GL Shen-Ong RL Strausberg E Birney DF Callen JF Cheng DR Cox NA Doggett NP Carter EE Eichler D Haussler JR Korenberg CC Morton D Albertson G Schuler PJ de Jong BJ Trask Integration of cytogenetic landmarks into the draft sequence of the human genome Nature 409 2001 953 958
31. D Karolchik R Baertsch M Diekhans TS Furey A Hinrichs YT Lu KM Roskin M Schwartz CW Sugnet DJ Thomas RJ Weber D Haussler WJ Kent The UCSC Genome Browser Database Nucleic Acids Res 31 2003 51 54
32. SD Moore SR Herrick TA Ince MS Kleinman PD Cin CC Morton BJ Quade Uterine leiomyomata with t(10;17) disrupt the histone acetyltransferase MORF Cancer Res 64 2004 5570 5577
33. TA Bismar F Demichelis A Riva R Kim S Varambally L He J Kutok JC Aster J Tang R Kuefer MD Hofer PG Febbo AM Chinnaiyan MA Rubin Defining aggressive prostate cancer using a 12-gene model Neoplasia 8 2006 59 68
34. NC Christacos BJ Quade P Dal Cin CC Morton Uterine leiomyomata with deletions of Ip represent a distinct cytogenetic subgroup associated with unusual histologic features Genes Chromosom Cancer 45 2006 304 312
35. BJ Quade TY Wang K Sornberger P Dal Cin GL Mutter CC Morton Molecular pathogenesis of uterine smooth muscle tumors from transcriptional profiling Genes Chromosom Cancer 40 2004 97 108
36. M Bustin Regulation of DNA-dependent activities by the functional motifs of the high-mobility-group chromosomal proteins Mol Cell Biol 19 1999 5237 5246
37. M Klotzbücher A Wasserfall U Fuhrmann Misexpression of wild-type and truncated isoforms of the high-mobility group I proteins HMGI-C and HMGI(Y) in uterine leiomyomas Am J Pathol 155 1999 1535 1542
38. BJ Quade P Dal Cin DM Neskey S Weremowicz CC Morton Intravenous leiomyomatosis: molecular and cytogenetic analysis of a case Mod Pathol 15 2002 351 356
39. P Dal Cin BJ Quade DM Neskey MS Kleinman S Weremowicz CC Morton Intravenous leiomyomatosis is characterized by a der(14)t(12;14)(q15;q24) Genes Chromosom Cancer 36 2003 205 206
40. H Kuroda I Konishi K Nanbu M Mandai T Komatsu S Yamamoto H Yamabe A Kida T Mori Malignant plexiform tumor of the uterus: an unusual variant of epithelioid leiomyosarcoma Gynecol Oncol 63 1996 270 275
41. C Karaiskos N Pandis G Bardi K Sfikas A Tserkezoglou S Fotiou S Heim Cytogenetic findings in uterine epithelioid leiomyomas Cancer Genet Cytogenet 80 1995 103 106
42. MS Sargent S Weremowicz MS Rein CC Morton Translocations in 7q22 define a critical region in uterine leiomyomata Cancer Genet Cytogenet 77 1994 65 68