The site of infection and ethnicity of the patient influence the biological pathways to HPV-induced mucosal cancer

Modern Pathology

Volumn 17, Issue 9, 2004, Pages 1031-1037

  Li, Wei ^a,b   Thompson, Carol H ^b   Cossart, Yvonne E ^b   O'Brien, Christopher J ^a   Liu, Jihong ^b,c   Scolyer, Richard A ^a   Carter, Jonathan R ^a   Dalrymple, Christopher ^a   Rose, Barbara R ^a,b,d  

^a ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^d CANCER INSTITUTE NSW   (Australia)

Author keywords

Cell cycle proteins; Cervical cancer; E6 E7; Human papillomavirus; Tonsillar cancer

Indexed keywords

CELL CYCLE PROTEIN; CYCLIN D1; PROTEIN E6; PROTEIN E7; PROTEIN P16; PROTEIN P21; PROTEIN P53; RETINOBLASTOMA PROTEIN;

ADULT; AGED; ARTICLE; AUSTRALIA; CARCINOGENESIS; CHINESE; ETHNOLOGY; FEMALE; HEAD AND NECK CARCINOMA; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFECTION; MAJOR CLINICAL STUDY; MUCOSA; PAPILLOMA VIRUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; QUANTITATIVE ANALYSIS; SQUAMOUS CELL CARCINOMA; TONSIL CARCINOMA; UTERINE CERVIX CANCER;

ADULT; AGED; AGED, 80 AND OVER; AUSTRALIA; CARCINOMA, SQUAMOUS CELL; CELL CYCLE PROTEINS; CHINA; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; NEOPLASM STAGING; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; RETINOBLASTOMA PROTEIN; TONSILLAR NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS; UTERINE CERVICAL NEOPLASMS;

EID: 4344700645     PISSN: 08933952     EISSN: None     Source Type: Journal    
DOI: 10.1038/modpathol.3800155     Document Type: Article

References (41)

1. Zur Hausen H. Oncogenic DNA viruses. Oncogene 2001;20:7820-7823.
2. Andl T, Kahn T, Pfuhl A, et al. Etiological involvement of oncogenic human papillomavirus in tonsillar squamous cell carcinomas lacking retinoblastoma cell cycle control. Cancer Res 1998;58:5-13.
3. Wilczynski SP, Lin BT, Xie Y, et al. Detection of human papillomavirus DNA and oncoprotein overexpression are associated with distinct morphological patterns of tonsillar squamous cell carcinoma. Am J Pathol 1998; 152:145-156.
4. Mellin H, Friesland S, Lewensohn R, et al. Human papillomavirus (HPV) DNA in tonsillar cancer: clinical correlates, risk of relapse, and survival. Int J Cancer 2000;89:300-304.
5. Wiest T, Schwarz E, Enders C, et al. Involvement of intact HPV16 E6/E7 gene expression in head and neck cancers with unaltered p53 status and perturbed pRb cell cycle control. Oncogene 2002;21:1510-1517.
6. Skomedal H, Kristensen GB, Lie AK, et al. Aberrant expression of the cell cycle associated proteins TP53, MDM2, p21, p27, cdk4, cyclin D1, RB, and EGFR in cervical carcinomas. Gynecol Oncol 1999;73:223-228.
7. Cheung TH, Lo KW, Yu MM, et al. Aberrant expression of p21(WAF1/CIP1) and p27(KIP1) in cervical carcinoma. Cancer Lett 2001;172:93-98.
8. Kim YT, Cho NH, Park SW, et al. Under expression of cyclin-dependent kinase (CDK) inhibitors in cervical carcinoma. Gynecol Oncol 1998;71:38-45.
9. Milde-Langosch K, Riethdorf S. Role of cell-cycle regulatory proteins in gynecological cancer. J Cell Physiol 2003;196:224-244.
10. Kim YT, Cho NH, Park SW, et al. Underexpression of cyclin-dependent kinase (CDK) inhibitors in cervical carcinoma. Gynecol Oncol 1998;71:38-45.
11. Milde-Langosch K, Albrecht K, Joram S, et al. Presence and persistence of HPV infection and p53 mutation in cancer of the cervix uteri and the vulva. Int J Cancer 1995;63:639-645.
12. Snijders PJ, Steenbergen RD, Top B, et al. Analysis of p53 status in tonsillar carcinomas associated with human papillomavirus. J Gen Virol 1994;75: 2769-2775.
13. Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993;366:704-707.
14. Klussmann JP, Weissenborn SJ, Wieland U, et al. Prevalence, distribution, and viral load of human papillomavirus 16 DNA in tonsillar carcinomas. Cancer 2001;92:2875-2884.
15. Li W, Thompson CH, Cossart YE, et al. The expression of key cell cycle markers and presence of human papillomavirus in squamous cell carcinoma of the tonsil. Head Neck 2004;26:1-9.
16. Lu DW, El-Mofty SK, Wang HL. Expression of p16, Rb, and p53 proteins in squamous cell carcinomas of the anorectal region harboring human papillomavirus DNA. Mod Pathol 2003;16:692-699.
17. Klaes R, Friedrich T, Spitkovsky D, et al. Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int J Cancer 2001;92:276-284.
18. Sano T, Oyama T, Kashiwabara K, et al. Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions. Am J Pathol 1998;153:1741-1748.
19. Salcedo M, Taja L, Utrera D, et al. Changes in retinoblastoma gene expression during cervical cancer progression. Int J Exp Pathol 2002;83:275-286.
20. Parker MF, Arroyo GF, Geradts J, et al. Molecular characterization of adenocarcinoma of the cervix. Gynecol Oncol 1997;64:242-251.
21. Amortegui AJ, Meyer MP, Elborne VL, et al. p53, retinoblastoma gene product, and cyclin protein expression in human papillomavirus virus DNA-positive cervical intraepithelial neoplasia and invasive cancer. Mod Pathol 1995;8:907-912.
22. Werness BA, Wang HQ, Chance J, et al. p53-independent expression of p21waf1/cip1 in preinvasive and invasive squamous neoplasms of the uterine cervix. Mod Pathol 1997;10:578-584.
23. Li W, Thompson CH, O'Brien CJ, et al. Human papillomavirus positivity predicts favourable outcome for squamous carcinoma of the tonsil. Int J Cancer 2003;106:553-558.
24. Rose BR, Thompson CH, Simpson JM, et al. Human papillomavirus deoxyribonucleic acid as a prognostic indicator in early-stage cervical cancer: a possible role for type 18. Am J Obstet Gynecol 1995;173: 1461-1468.
25. Resnick RM, Cornelissen MT, Wright DK, et al. Detection and typing of human papillomavirus in archival cervical cancer specimens by DNA amplification with consensus primers. J Natl Cancer Inst 1990; 82:1477-1484.
26. de Roda Husman AM, Walboomers JM, van den Brule AJ, et al. The use of general primers GP5 and GP6 elongated at their 3′ ends with adjacent highly conserved sequences improves human papillomavirus detection by PCR. J Gen Virol 1995;76:1057-1062.
27. Tieben LM, ter Schegget J, Minnaar RP, et al. Detection of cutaneous and genital HPV types in clinical samples by PCR using consensus primers. J Virol Methods 1993;42:265-279.
28. Li W, Thompson CH, Xin D, et al. Absence of human papillomavirus in tonsillar squamous cell carcinomas from Chinese patients. Am J Pathol 2003; 163:2185-2189.
29. Sano T, Oyama T, Kashiwabara K, et al. Immunohistochemical overexpression of p16 protein associated with intact retinoblastoma protein expression in cervical cancer and cervical intraepithelial neoplasia. Pathol Int 1998;48:580-585.
30. Erber R, Klein W, Andl T, et al. Aberrant p21(CIP1/ WAF1) protein accumulation in head-and-neck cancer. Int J Cancer 1997;74:383-389.
31. Mantel NHW. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959;22:719-748.
32. Deacon JM, Evans CD, Yule R, et al. Sexual behaviour and smoking as determinants of cervical HPV infection and of CIN3 among those infected: a case-control study nested within the Manchester cohort. Br J Cancer 2000;83:1565-1572.
33. Choo KB, Chong KY. Absence of mutation in the p53 and the retinoblastoma susceptibility genes in primary cervical carcinomas. Virology 1993;193: 1042-1046.
34. Klussmann JP, Gultekin E, Weissenborn SJ, et al. Expression of p16 protein identifies a distinct entity of tonsillar carcinomas associated with human papillomavirus. Am J Pathol 2003;162:747-753.
35. Lu DW, El-Mofty SK, Wang HL. Expression of p16, Rb, and p53 proteins in squamous cell carcinomas of the anorectal region harboring human papillomavirus DNA. Mod Pathol 2003;16:692-699.
36. Murphy N, Ring M, Killalea AG, et al. p16INK4A as a marker for cervical dyskaryosis: CIN and cGIN in cervical biopsies and ThinPrep smears. J Clin Pathol 2003;56:56-63.
37. Cho NH, Kim YT, Kim JW. Correlation between G1 cyclins and HPV in the uterine cervix. Int J Gynecol Pathol 1997;16:339-347.
38. Clarke B, Chetty R. Cell cycle aberrations in the pathogenesis of squamous cell carcinoma of the uterine cervix. Gynecol Oncol 2001;82:238-246.
39. Saenz Robles MT, Symonds H, Chen J, et al. Induction versus progression of brain tumor development: differential functions for the pRB- and p53-targeting domains of simian virus 40T antigen. Mol Cell Biol 1994;14:2686-2698.
40. Jones DL, Thompson DA, Suh-Burgmann E, et al. Expression of the HPV E7 oncoprotein mimics but does not evoke a p53-dependent cellular DNA damage response pathway. Virology 1999;258:406-414.
41. Fleming I, Cooper JS, Henson DE, et al. American Joint Committee on Cancer Staging Manual, 5 ed. Lippincott-Raven:Philadelphia, 1997.