Evaluating barriers to bioavailability in vivo: Validation of a technique for separately assessing gastrointestinal absorption and hepatic extraction

Pharmaceutical Research

Volumn 21, Issue 8, 2004, Pages 1457-1462

  Letendre, Laura ^a   Scott, Mark ^a   Dobson, Glenn ^a   Hidalgo, Ismael ^a   Aungst, Bruce ^a  

^a Absorption Systems   (United States)

Author keywords

absorption; bioavailability; hepatic extraction

Indexed keywords

AMOXICILLIN; ATENOLOL; CYTOCHROME P450; PHENAZONE; PROPRANOLOL; TESTOSTERONE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CALCULATION; COLON; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; EXPERIMENTAL RAT; EXTRACTION; GASTROINTESTINAL ABSORPTION; HALF LIFE TIME; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; LIVER; LIVER HILUS; MALE; NONHUMAN; PORTAL VEIN; PRIORITY JOURNAL; RAT; RAT STRAIN; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

AMOXICILLIN; ANIMALS; ANTIPYRINE; AREA UNDER CURVE; ATENOLOL; BIOLOGICAL AVAILABILITY; GASTROINTESTINAL TRACT; INTESTINAL ABSORPTION; LIVER; MALE; MODELS, ANIMAL; PROPRANOLOL; RATS; RATS, SPRAGUE-DAWLEY; TESTOSTERONE;

EID: 4344698275     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:PHAM.0000036921.87928.72     Document Type: Article

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