Differential effect of ginsenoside metabolites of the 5-HT3A receptor-mediated ion current in Xenopus oocytes

Molecules and Cells

Volumn 17, Issue 1, 2004, Pages 51-56

  Lee, Byung Hwan ^d   Jeong, Sang Min ^d   Lee, Jun Ho ^d   Kim, Dong Hyun ^a   Kim, Jong Hoon ^d   Kim, Jai Il ^b   Shin, Ho Chul ^c   Lee, Sang Mok ^d   Nah, Seung yeol ^d  

^a Kyung Hee University   (South Korea)

^b Gwangju Institute of Science and Technology (GIST)   (South Korea)

^c Korea Institute of Toxicology   (South Korea)

^d Konkuk University   (South Korea)

Author keywords

5 HT3A receptor; CK and M4; Ginsenoside metabolites; Ligand gated ion channels; Panax ginseng; Serotonin; Xenopus oocytes

Indexed keywords

20 S PROTOPANAXADIOL 20 O BETA DEXTRO GLUCOPYRANOSIDE; 20 S PROTOPANAXATRIOL; DRUG METABOLITE; GINSENOSIDE; PANAXYTRIOL; RNA; SEROTONIN; SEROTONIN 3 RECEPTOR; SEROTONIN 3A RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; ELECTRODE; FEMALE; IC 50; ION CURRENT; NONHUMAN; OOCYTE; PROTEIN EXPRESSION; VOLTAGE CLAMP; XENOPUS LAEVIS;

ANIMALS; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; GINSENOSIDES; INHIBITORY CONCENTRATION 50; INTESTINES; IONS; MODELS, CHEMICAL; OOCYTES; PANAX; PATCH-CLAMP TECHNIQUES; RECEPTORS, SEROTONIN, 5-HT3; RNA, COMPLEMENTARY; XENOPUS;

PANAX; PANAX GINSENG;

EID: 4344688062     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Abe, T. (1965) Clinical studies of the vitamins. J. Jpn. Soc. Inter. Med. 54, 989-1006.
2. 2 on long-term potentiation in the dentate gyrus of rat. Brain Res. 649, 7-11.
3. Arias, H. R. (1996) Luminal and non-luminal non-competitive inhibitor binding sites on the nicotinic acetylcholine receptor. Mol. Membr. Biol. 13, 1-17.
4. Attele, A. S., Wu, J. A., and Yuan, C. S. (1999) Ginseng pharmacology: multiple constituents and multiple actions. Biochem. Pharmacol. 58, 1685-1693.
5. Choi, S., Jung, S. Y., Lee, J. H., Sala, F., Criado, M., Mulet, J., Valor, L. M., Sala, S., Engel, A. G., and Nah, S. Y. (2002) Effects of ginsenosides, active components of ginseng, on nicotinic acetylcholine receptors expressed in Xenopus oocytes. Eur. J. Pharmacol. 442, 37-45.
6. 3A receptor-mediated ion current in Xenopus oocytes. Mol. Cells 15, 108-113.
7. Dang, H., England, P. M., Farivar, S. S., Dougherty, D. A., and Lester, H. A. (2000) Probing the role of a conserved M1 proline residue in 5-hyroxytryptamine3 receptor gating. Mol. Pharmacol. 57, 1114-1122.
8. Dascal, N. (1987) The use of Xenopus oocytes for the study of ion channels. CRC Crit. Rev. Biochem. 22, 317-387.
9. Fortney, J. T., Gan, T. J., Graczyk, S., Wetchler, B., Melson, T., Kahlil, S., Mckenzie, R., Pamillo, S., Glass, P. S., Moote, C., Wermeling, D., Parasuraman, T. V, Duncan, B., and Creed, M. R. (1998) A comparison of the efficacy, safety, and patient satisfaction of ondansetron versus droperidol as antiemetics for elective outpatient surgical procedures. S3A-409 and S3A-410 Study Groups. Anesth. Analg. 86, 731-738.
10. Hasegawa, H. J., Sung, J. H., Matsumiya, S., and Uchiyama, M. (1996) Main ginseng saponin metabolites formed by intestinal bacteria. Planta Med. 62, 453-457.
11. Hasegawa, H., Suzuki, R., Nagaoka, T., Tezuka, Y., Kadota, S., and Saiki, I. (2002) Prevention of growth and metastasis of murine melanoma through enhanced natural-killer cytotoxicity by fatty acid-conjugate of protopanaxatriol. Biol. Pharm. Bull. 25, 861-866.
12. Heidman, T., Oswald, R. E., and Changeux, J. P. (1983) Multiple sites of action for noncompetitive blockers on acetylcholine receptor rich membrane fragments from Torpedo marmorata. Biochemistry 22, 3112-3127.
13. 3 receptor channel. Annu. Rev. Physiol. 57, 447-468.
14. Kanaoka, M., Akao, T., and Kobashi, K. (1994) Metabolism of ginseng saponins, ginsenosides by human intestinal flora. J. Trad. Med. 11, 241-245.
15. Karikura, M., Miyase, T., Tanizawa, H., Taniyawa, T., and Takino, Y. (1991) Studies on absorption, distribution, excretion and metabolism of ginsenog saponins. VII Comparison of the decomposition modes of ginsenoside Rb1 and Rb2 in the digestive tract of rats. Chem. Pharm. Bull. 39, 400-404.
16. Kim, S., Ahn, K., Oh, T. H., Nah, S. Y., and Rhim, H. (2002) Inhibitory effect of ginsenosides on NMDA receptor-mediated signals in rat hippocampal neurons. Biochem. Biophys. Res. Commun. 296, 247-254.
17. 3 protect cultured rat cortical cells from glutamate-induced neurodegenaration. J. Neurosci. Res. 53, 426-432.
18. Kudo, K., Tachikawa, E., Kashimoto, T., and Takahashi, E. (1998) Properties of ginseng saponin inhibition of catecholamine secretion in bovine chromaffin cells. Eur. J. Pharmacol. 341, 139-144.
19. Lee, J. H., Kim, S. R., Bae, C. S., Kim, D., Hong, H. N., and Nah, S. Y. (2002) Protective effect of ginsenosides, active ingredient of Panax ginseng, on kainic acid-induced neurotoxicity in rat hippocampus. Neurosci. Lett. 325, 129-133.
20. 3 receptor, a serotonin-gated ion channel. Science 254, 432-437.
21. Ortells, M. O. and Lunt, G. G. (1995) Evolutionary history of the ligand-gated ion channel superfamily of receptors. Trends Neurosci. 18, 121-127.
22. Polati, E., Verlato G., Finco, G., Monsaner, W., Grosso, S., Gottin, L., Pinaroli, A. M., and Ischia, S. (1997) Ondansetron versus metoclopramide in the treatment of postoperative nausea and vomiting. Anesth. Analg. 85, 395-399.
23. 2 on human neuronal nicotinic acetylcholine receptors. J. Pharmacol. Exp. Ther. 301, 1052-1059.
24. Seong, Y. H., Shin, C. H., Kim, H. S., and Baba, A. (1995) Inhibitory effect of ginseng total saponins on glutamate-induced swelling of cultured astrocytes. Biol. Pharm. Bull. 18, 1776-1778.
25. Sine, S. M. and Taylor, P. (1982) Local anesthetic and histrionicotoxin are allosteric inhibitors of the acetylcholine receptor. J. Biol. Chem. 257, 8106-8114.
26. + influx and catecholamine secretion in bovine adrenal chromaffin cells. Effects of ginseng saponins on responses induced by various receptor stimuli. J. Pharm. Exp. Ther. 273, 629-636.
27. Wakabayashi, C., Hasegawa, H., Murata, J., and Saiki, I. (1997) In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration. Oncol. Res. 9, 411-417.
28. Wakabayashi, C., Murakami, K., Hasegawa, H., Murata, J., and Saiki, I. (1998) An intestinal bacterial metabolite of ginseng protopanaxadiol saponins has the ability to induce apoptosis in tumor cells. Biochem. Biophys. Res. Commun. 249, 725-730.