Effect of hydrocortisone on reperfusion injury and on mucosal repair after experimental venous ischemia in the equine jejunum;Efeito da hidrocortisona sobre a lesão de reperfusão e reparação da mucosa após isquemia venosa experimental no jejuno de eqüinos

Arquivo Brasileiro de Medicina Veterinaria e Zootecnia

Volumn 55, Issue 5, 2003, Pages 539-549

  Alves, G E S ^a   Matos, J J R T ^b   Faleiros, R R ^a   Santos, R L ^a   Marques Jr , A P ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b Ctro Estud Clin Cir Animais P ^*

Author keywords

Equine; Gastroenterology; Hydrocortisone; Ischemia; Reperfusion

Indexed keywords

HALOTHANE; HYDROCORTISONE SODIUM SUCCINATE; SODIUM CHLORIDE;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DRUG EFFECT; EDEMA; GASTROINTESTINAL HEMORRHAGE; HORSE; INTESTINE BIOPSY; ISCHEMIA; JEJUNUM DISEASE; JEJUNUM MUCOSA; LYMPHOCYTIC INFILTRATION; NONHUMAN; PROPHYLAXIS; REPERFUSION INJURY; SAMPLING; STATISTICAL SIGNIFICANCE; STIMULATION;

ANIMALIA; EQUIDAE; EQUUS CABALLUS;

EID: 4344668607     PISSN: 01020935     EISSN: None     Source Type: Journal    
DOI: 10.1590/s0102-09352003000500005     Document Type: Article

References (59)

1. ABOOD, S.K.; McLOUGHLIN, M.A.; BAILEY, M.Q. et al. Effect of glutamine on mucosal permeability in a canine model of ischemia and reperfusion injury. Vet. Surg., v.23, p.421, 1994.
2. APPLETON, I.; TOMLINSON, A.T.; WILLOUGHBY, D.A. Induction of cyclo-oxygenase and nitric oxide synthase in inflammation. Adv. Physiol., v.35, p.27-78, 1996.
3. BEHREND, E.N.; KEMPPAINEN, R.J. Glucocorticoid therapy: pharmacology, indications, and complications. Vet. Clin. North Am.: Small Anim. Pract., v.27, p. 187-213, 1997.
4. BLIKSLAGER, A.T.; ROBERTS, M.C. Mechanisms of intestinal mucosal repair. J. Am. Vet. Med. Assoc., v.211, p.1437-1441, 1997b.
5. BLIKSLAGER, A.T.; ROBERTS, M.C.; ARGENZIO, R.A. Prostaglandins I2 and E2 have a synergistic role in rescuing epithelial barrier function in ischemic-injured intestine. In: EQUINE COLIC RESEARCH SYMPOSIUM, 6, 1998, Athens. Proceedings... Athens: 1998, p.40. Abstract.
6. CHIU, C.; McARDLE, A.H.; BROWN, R. et al. Intestinal mucosal lesion in low flow states. Arch. Surg., v.101, p.484-488, 1970.
7. DABAREINER, R.M; WHITE, N. A.; DONALDSON, L.L. et al. Evaluation of Carolina rinse as a treatment for ischemia-reperfusion of the equine jejunum. Vet. Surg., v.27, p.521, 1998.
8. DUBOIS, R.N.; EBERHART, C.E.; WILLIAMS, C.S. Introduction to eicosanoids and the gastroenteric tract. Gastroent. Clin. North Am., v.25, p.267-277, 1996.
9. DUCHARME, N.G.; HACKETT, R.P.; DUCHARME, G.R. et al. Surgical treatment of colic: results in 181 horses. Vet. Surg., v.12, p.206-209, 1983.
10. FALEIROS, R.R. Isquemia e reperfusão experimental no cólon menor de eqüinos. 1997. 70p. Dissertação (Mestrado em Medicina Veterinária). Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte.
11. FALEIROS, R.R.; MACORIS, D.G.; ALESSI, A.C. et al. Effect of intraluminal distension on microvasculaar perfusion in the equine small colon. Am. J. Vet. Res. v.63, p. 1292-1297, 2002.
12. FLAHERTY, J.T.; WEISFELDT, M.L. Reperfusion injury. Free Rad. Biol. Med., v. 5, p. 409-419, 1988.
13. FORSYTH, S.F.; GUILFORD, W.G. Ischaemia-reperfusion injury-a small animal perspective. Br. Vet. J., v. 151, p.281-298, 1995.
14. FOX, A.D.; KRIPKE, S.A.; BERMAN, J.M. et al. Dexamethasone administration induces increased glutaminase specific activity in the jejunum and colon. J. Surg. Res., v.44, p.391-396, 1988.
15. FREEMAN, D.E.; GENTILE, D.G.; RICHARDSON, D.W. et al. Comparision of clinical judgment, doppler ultrasound, and fluorescein fluorescence as methods for predicting intestinal viability in the pony. Am. J. Vet. Res., v.49, p.895-900, 1988a.
16. FREEMAN, D.E.; CIMPRICH, R.E.; RICHARDSON, D.W. et al. Early mucosal healing and chronic changes in pony jejunum after various types of strangulation obstruction. Am. J. Vet. Res., v.49, p.810-818, 1988b.
17. GAFFIN, S.L; GATHIRAM, P.; WELLS, M. et al. Effect of corticosteroid prophylaxis on lipopolysaccharide levels associated with intestinal ischemia in cats. Crit. Care Med., v.14, p.889-891, 1986.
18. HAGLUND, U.; HULTÉN, L.; AHREN, C. et al. Mucosal lesions in the human small intestine in shock. Gut, v. 16, p.979-984, 1975.
19. HAMMERSCHMIDT, D.E.; WHITE, J.G.; CRADDOCK, P.R. et al. Corticosteroids inhibit complement-induced granulocyte aggregation. J. Clin. Invest., v.63, p.798-803, 1979.
20. HARWARD, T.R.S.; COE, D.; SOUBA, W.W. et al. Glutamine preserves gut glutathione levels during intestinal ischemia/reperfusion. J. Surg. Res., v.56, p.351-355, 1994.
21. HIGGINS, A.J.; LEES, P. The acute inflammatory process, arachidonic acid metabolism and the mode of action of antiinflammatory drugs. Equine Vet. J., v.16, p.163-173, 1984.
22. HOOGMOED, L.V.; SNYDER, J. Adjunctive methods in equine gastrointestinal surgery. Vet. Clin. North Am.: Equine Pract., v.13, p.221-242, 1997.
23. HOOGMOED, L.V.; SNYDER, J. Use of pelvic flexure biopsies to predict survivability of horses following large colon torsion. In: EQUINE COLIC RESEARCH SYMPOSIUM, 6, 1998, Athens. Proceedings... Athens: 1998, p.64. Abstract.
24. HORNE, M.M.; PASCOE, P.J.; DUCHARME, N.G. et al. Attempts to modify reperfusion injury of equine jejunal mucosa using dimethylsulfoxide, allopurinol, and intraluminal oxygen. Vet. Surg., v.23, p.241-249, 1994.
25. HUBBELL, J.A.E. Monitoring. In: MUIR, W.W.; HUBBELL, J.A.E. Equine anaesthesia monitoring and emergency therapy. St. Louis: Mosby, 1991. p.153-159.
26. KOOREMAN, K.; BABBS, C.; FESSLER, J. Effect of ischemia and reperfusion on oxidative processes in the large colon and jejunum of horses. Am. J. Vet. Res., v.59, p.340-346, 1998.
27. KUBES, P.; HUNTER, J.; GRANGER, D.N. Ischemia-reperfusion-induced feline intestinal dysfunction: importance of granulocyte recruitment. Gastroenterology, v.103, p.807-812, 1992.
28. LAING, E.J. The effects of chemotherapy and radiation on wound healing. In: HARARI, J. (Ed). Surgical complications and wound healing in the small animal practice. Philadelphia: Saunders, 1993. p.125-141.
29. LUDGREN, O.; HAGLUND, U. The pathophysiology of the intestinal countercurrent exchanger. Life Sci., v.23, p. 1411-1422, 1978.
30. MASFERRER, J.L.; SEIBERT, K.; ZWEIFEL, B. et al. Endogenous glucocorticoids regulate an inducible cyclooxygenase enzyme. Proc. Natl. Acad. Sci. USA, v.89, p.3917-3921, 1992.
31. MAY, S.A. Anti-inflamatory Agents. In: ROBINSON, N.E. (Ed). Current therapy in equine medicine. 3 ed. Philadelphia: Saunders, 1992. p.14-16.
32. McCORMACK, S.A.; VIAR, M.J.; JOHNSTON, L.R. Migration of IEC-6 cells: a model for mucosal healing. Am. J. Physiol., v.263, p.G426-G435, 1992.
33. MESCHTER, C.L.; TYLER, D.E.; WHITE, N.A. et al. Histologic findings in the gastrointestinal tract of horses with colic. Am. J. Vet. Res., v.47, p.598-606, 1986.
34. MITSUDO, S.; BRANDT, L.J. Pathology of intestinal ischemia. Surg. Clin. North Am., v.72, p.43-63, 1992.
35. MOORE, J.N. Pathophysiology of circulatory shock. In: WHITE, N.A. (Ed). The equine acute abdomen. Philadelphia: Lea & Febiger, 1990. p.89-100.
36. MOORE, R.M.; BERTONE, A.L; BAILEY, M.Q. et al. Neutrophil accumulation in the large colon of horses during low-flow ischemia and reperfusion. Am. J. Vet. Res., v.55, p. 1454-1463, 1994.
37. MOORE, R.M.; MUIR, W.W.; BERTONE, A.L. et al. Effects of dimethyl sulfoxide, allopurinol,21-aminosteroid u-74389G, and manganese cloride on low-flow ischemia and reperfusion of the large colon in horses. Am. J. Vet. Res., v.56, p.671-687, 1995a.
38. MOORE, R.M.; MUIR, W.W.; GRANGER, D.N. Mechanisms of gastrointestinal ischemia-reperfusion injury and therapeutic interventions: a review and its implications in the horse. J. Vet. Int. Med., v.9, p.115-132, 1995b.
39. MUHLBACHER, F.; KAPADIA, C.R.; COLPOYS, M.F. et al. Effects of glucocorticoids on glutamine metabolism in skeletal muscle. Am. J. Physiol., v.247, p.E75-E83, 1984.
40. OTAMIRI, T.; FRANZÉN, L.; LINDMARK, D. et al. Increased phospholipase A2 and decreased lysophospholipase activity in the small intestinal mucosa after ischaemia and revascularisation. Gut, v.28, p.1445-1453, 1987.
41. OTAMIRI, T.; TAGESSON, C. Role of phospholipase A2 and oxygenated free radicals in mucosal damage after small intestinal ischemia and reperfusion. Am. J. Surg., v.157, p.562-566, 1989.
42. REEVES, M.J.; VASTEENHOUSE., J.; STASHAK, T.S. et al. Failure to demonstrate reperfusion injury following ischaemia of the equine large colon using dimethyl sulphoxide. Equine Vet. J., v.22, p. 126-132, 1990.
43. ROBERTSON, J.T.; MUIR, W.W.; SAMS, R. Cardiopulmonary effects of butorphanol, tartarate in horses. Am. J. Vet. Res., v.42, p.41-44, 1981.
44. SALLOUM, R.M.; DUCKWORTH, D.; MADISON, J.B. et al. Characteristics of L-glutamine transport in equine jejunal brush border membrane vesicles. Am. J. Vet. Res., v.54, p.152-157, 1993.
45. SAMPAIO, I.B.M. Estatística aplicada à experimentaç ão animal. Belo Horizonte: FEP-MVZ, 1998. 221p.
46. SARANTOS, P.; ABOUHAMZE, A., SOUBA, W.W. Glucocorticoids regulate intestinal glutaminase expression. Surgery, v.112, p.278-283, 1992.
47. SLAUSON, D.O.; COOPER, B.J. Mechanisms of disease; a textbook of comparative general pathology. 2 ed. Baltimore: Willians & Wilkins, 1990. p. 167-301: Inflammation and repair.
48. SOUBA, W.W.; KLIMBERG, V.S.; PLUMLEY, D.A. et al. The role of glutamine in maintaining a healthy gut and supporting the metabolic response to injury and infection. J. Surg. Res., v.48, p.383-391, 1990.
49. SOUBA, W.W.; SMITH, R.J.; WILMORE, D.W. Effects of glucocorticoids on glutamine metabolism in visceral organs. Metabolism, v.34, p.450-456, 1985.
50. STASHAK, T.S. Equine wound management. Philadelphia: Lea & Febiger, 1991. p. 19-35: Selected factors that affect wound healing.
51. STICK, J.A.; LOEFFLER, B.S.; ARDEN, W.A. Butorphanol tartarate: effects on vascular pressure, jejunal blood flow, vascular resistance, O2 extraction, and O2 uptake in ponies. Vet. Surg., v.18, p.67, 1989.
52. SULLINS, K.E.; STASHAK, T.S.; MERO, K.N. Pathologic changes associated with induced small intestinal strangulation obstruction and nonstrangulating infarction in horses. Am. J. Vet. Res., v.46, p.913-916, 1985.
53. TAGESSON, C.; FRANZÉN, L.; DAHL, G. et al. Lysophosphatidylcholine increases rat ileal permeability to macromolecules. Gut, v.26, p.369-377, 1985.
54. VATISTAS, N.J.; SNYDER, J.R.; HILDEBRAND, S.V. et al. Effects of U-74389G, a novel 21-aminosteroid, an small intestinal ischemia and reperfusion injury in horses. Am. J. Vet. Res., v.57, p.762-770, 1996.
55. WHITE, N.A. Epidemiology and etiology of colic. In: WHITE, N.A. (Ed). The equine acute abdomen. Philadelphia: Lea & Febiger, 1990. p.49-64.
56. WHITE, N.A.; MOORE, J.N.; TRIM, C.M. Mucosal alterations in experimentally induced small intestinal strangulation obstruction in ponies. Am. J. Vet. Res., v.41, p.193-198, 1980.
57. WILSON, D.V.; PATTERSON, J.S.; STICK, J.A. et al. Histologic and ultrastructural changes after large-colon tordsion, with and without use of a specific platelet-activating factor antagonist (WEB 2086), in ponies. Am. J. Vet. Res., v.55, p.681-688, 1994.
58. ZIMMEL, D.N.; BLIKSLAGER, A.T. The role of ciclooxigenases in repair of ischemic-injured intestine. In: EQUINE COLIC RESEARCH SYMPOSIUM, 6, 1998, Athens. Proceedings... Athens: 1998, p. 16, Abstract.
59. ZIMMERMAN, B.J.; GUILLORY, D.J.; GRISHAM, M.B. et al. Role of leukotriene B4 in granulocyte infiltration into the postischemic feline intestine. Gastroentereology, v.99; p.1358-1363, 1990.