Effects of U-74389G, a novel 21-aminosteroid, on small intestinal ischemia and reperfusion injury in horses

American Journal of Veterinary Research

Volumn 57, Issue 5, 1996, Pages 762-770

  Vatistas, Nicholas J ^a   Snyder, Jack R ^a   Hildebrand, Susan V ^a   Harmon, Faye A ^a   Woliner, Michael J ^a   Barry, Sean J ^b   Nieto, J ^a   Henry, Pegeen ^a   Enos, L Reed ^a   Magliano, David ^a   Brown, Scott A ^d   Drake, Christiana ^c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b WF Goodman Center for Comparative Medical Genetics School of Veterinary Medicine   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

21 [4 [2,6 BIS(1 PYRROLIDINYL) 4 PYRIMIDINYL] 1 PIPERAZINYL]PREGNA 1,4,9(11) TRIENE 3,20 DIONE; ANTIOXIDANT; MALONALDEHYDE; PEROXIDASE; PREGNANE DERIVATIVE;

ANIMAL; ANIMAL DISEASE; ARTICLE; CHEMISTRY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE MODEL; DOSE RESPONSE; FEMALE; HORSE; HORSE DISEASE; INTESTINE MUCOSA; INTRAVENOUS DRUG ADMINISTRATION; JEJUNUM; MALE; MESENTERIC BLOOD VESSEL OCCLUSION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; REPERFUSION INJURY; TIME; VASCULARIZATION;

ANIMALS; ANTIOXIDANTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HORSE DISEASES; HORSES; INFUSIONS, INTRAVENOUS; INTESTINAL MUCOSA; JEJUNUM; MALE; MALONDIALDEHYDE; MESENTERIC VASCULAR OCCLUSION; PEROXIDASE; PREGNATRIENES; REPERFUSION INJURY; TIME FACTORS;

EID: 0030147419     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. McDonald MH, Pascoe JR, Stover SM Survival after small intestine resection and anastomosis in horses. Vet Surg 1989;18.415-423.
2. White NA, Moore JN, Trim CM. Mucosal alterations in experimentally induced small intestinal strangulation obstruction in ponies Am J Vet Res 1980,41: 193-138
3. Horne MM, Pascoe PJ, Ducharme NG, et al. Attempts to modify reperfusion injury of equine jejunal mucosa using dimethlysulfoxide, allopurinol and intralauminal oxygen. Vet Surg 1994;23: 241-249
4. Granger DN, Rutili G, McCord JM Superoxide radicals in feline intestinal ischemia. Gastroenterology 1981;81:22-29.
5. Grogaard B, Parks DA, Granger DN, et al Effects of ischemia and oxygen radicals on mucosal albumin clearance in intestine. Am J Physiol 1982:242:G448-G454.
6. Schoenberg MH, Muhl E, Selim D, et al. Post hypotensive generation of superoxide free radicals - possible role in the pathogenesis of intestinal mucosal damage. Acta Chir Scand 1984;150: 301-309
7. Schoenberg MH, Fredholm BB, Haglund U, et al Studies on the oxygen radical mechanism involved in the small intestinal reperfusion damage. Acta Physiol Scand 1985;124.581-589.
8. Younes M, Schoenberg MH, Jung H, et al Oxidative tissue damage following regional intestinal ischemia and reperfusion in the cat. Res Exp Med 1984,184:259-264.
9. Haglind E, Haglund U, Lundgren O, et al. Mucosal lesions of the small intestine after intestinal vascular obstruction in the rat. Acta Chir Scand 1985:151 147-150
10. Parks DA, Granger DN, Bulkey GB et al. Soybean trypsin inhibitor attenuated ischemic injury to the feline small intestine Gastroenterology 1985,89.6-12
11. Parks PO, Haglund U, Bulkley GB. The sequence of development of intestinal tissue injury after strangulation ischemia and reperfusion. Surgery 1990:107 574-580.
12. Parks DA, Bulkley GB, Granger DN. Role of oxygen-derived free radicals in digestive tract diseases. Surgery 1983;94:415-422.
13. Parks DA, Granger DN. Contributions of ischemia and repertusion to mucosal lesion formation. Am J Physiol 1986,250:G749-G753
14. Braughler JM, Pregenzer JF. The 21-aminosteroid inhibitors of lipid peroxidation: reactions with lipid peroxyl and phenoxy radicals. Free Radic Biol Med 1989;7:125-130.
15. Otamiri T. Oxygen radicals, lipid peroxidation, and neutrophil infiltration after small-intestinal ischemia and reperfusion. Surgery 1989;105:593-597.
16. Czyrko C, Steigman C, Turley DL, et al. The role of reperfusion injury in occlusive intestinal ischemia of the neonate: malondeaklehyde-derived fluorescent products and correlation of histology. J Surg Res 1991,51:1-4.
17. Janero DR Malondealdehyde and the thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radie Biol Med 1990;9:515-540.
18. Matsuki N, Tamura S, Ono K, et al. Exercised-induced phospholipid degradation in equine skeletal muscle and erythrocytes. J Vet Med Sci 1991,53:1001-1007.
19. Valenzuela A. The significance of malondealdehyde determination in the assessment of tissue oxidative stress. Life Sci 1991; 48:301-309.
20. Vatistas NJ, Snyder JR, Hildebrand SV, et al. Effects of the 21-aminosteroid U-74389G on ischemia and reperfusion injury of the ascending colon in horses. Am J Vet Res 1993;54:2155-2160.
21. Laws EG, Freeman DE. Significance of reperfusion injury after venous strangulation obstruction of the horse jejunum Vet Surg 1994;23:407
22. Younes M, Mohr A, Schoenhurg MH, et al. Inhibition of lipid peroxidation by Superoxide dismutase following regional intestinal ischemia and reperfusion. Res Exp Med 1987;187:9-17.
23. Krawisz JE, Sharon P, Stenson WF Quantitaive assay for acute intestinal inflammation based on myeloperoxidase activity. Gastroenterology 1984;87:1344-1350.
24. Grisham MB, Benoit JN, Granger DN. Assessment of leukocyte involvement durjng ischemia and reperfusion of intestine. Methods Enzymol 1986,551.729-742.
25. Grisham MB, Hernandez LA, Granger DN, Xanthine oxidase and neutrophil infiltration in intestinal ischemia. Am J Physiol 1986;251:G567-G574
26. Hernandez LA, Grisham MB, Twohig B, et al Role of neutrophils in ischemia-induced microvascular injury. Am J Physiol 1987,253:H699-H703.
27. Simpson PJ, Mickelson J, Fantone JC, et al. Iloprost inhibits neutrophil function in vitro and in vivo and limits experimental infarct size in canine heart. Circ Res 1987;60:666-673.
28. Weiss SJ Tissue destruction by neutrophils. N Engl J Med 1989;320.365-375.
29. Dimlich RVW, Tornheim PA, Kindel RM, et al Effects of a 21-aminosteroid (U-74006F) on cerebral metabolites and edema after severe experimental head trauma. Adv Neurol 1990:32:365-375
30. Yarbrough TB, Snyder JR, Harmon FA, et al. Evaluation of myeloperoxidase concentrations in experimentally induced equine colonic ischemia and reperfusion Equine Vet J 1994;26(1):67-69.
31. Moore RM, Bertone AL, Bailey MQ, et al. Neutrophil accumulation in the large colon of horses during low-flow ischemia and reperfusion. Am J Vet Res 1994;55:1454-1463
32. Lucchesi BR Modulation of leukocyte-mediated myocardial reperfusion injury. Ann Rev Physiol 1990;52:261-276.
33. Hall ED, Yonkers PA, McCall JM, et al. Effects of the 21-aminosteroid U74006F on experimental head injury in mice. J Neuiosurg 1988,68:456-461
34. Hernandez MC, Walters W, Toledo-Pereyra LH. Effect of a 21-aminosteroid and/or adenosme in the ischemic rat liver Transplant Proc 1991;23:2428-2429
35. Ovize M, de Lorgeril M, Ovize A, et al U-74006F, a novel 21-ammosteroid. inhibits in vivo lipid peroxidation but fails to limit infarct size in a canine model of myocardial ischemia reperfusion. Am Heart J 1991;122:681-689.
36. Thomas PD, Mao GD, Rabinovitch A, et al. Inhibition of superoxide-generatine NADPH oxidase of human neutrophils by lazaroids (21-aminosteroids and 2-methylaminoshromans). Biochem Pharmacol 1993,45 241-251.
37. Johnson G, Lefer AM Protective effects of a novel 21-aminosteroid during splanchnic artery occlusion. Circ Shock 1990;30. 155-164.
38. 2 inhibition prevents mucosal damage associated with small intestinal ischemia in rats. Gut 1988,29:489-494.
39. Carati CJ, Rambaldo S, Gannon BJ Changes in macromolecular permeability of microvessels in rat small intestine after total occlusion ischerma/reperfusion. Microcirc Endothelium Lymphatics 1988;4:69-86
40. Ravid M, Van-Dyk D, Bernheim J, et al. The protective effect of dimethyl sulfoxide in experimental ischemia of the intestine. Ann N Y Acad Sci 1983,41:100-104.
41. Debareiner RM, Snyder JR, White NA, et al Microvascular permeability and endothehal cell morphology with low-flow ischemia/reperfusion injury in the equine jejunum. Am J Vet Res 1995, 56:639-648.
42. Clark ET, Gewertz BL. Intermittent ischemia potentiates intestinal reperfusion. J Vasc Surg 1991,13:601-606.
43. Arden WA, Slocombe RF, Stick JA, et al. Morphologic and ultrastructural evaluation of effect of ischemia and dimethyl sulfoxide on equine jejunum. Am J Vet Res 1990;51:1784-1791
44. Meschter CL, Craig D, Hackett R. Histopathological and ultrastructural changes in simulated large colonic torsion and reperfusion in ponies. Equine Vet J 1991,23:426-433.
45. Reeves MJ, Vansteenhouse J, Stashak TS, et al. Failure to demonstrate reperfusion injury following ischemia of the equine large colon using dimethyl sulphoxide. Equine Vet J 1990;22:126-132.
46. Moore RM, Bertone AL, Muir WW, et al. Histopathologic evidence of reperfusion injury in the large colon of horses after low-flow ischemia Am J Vet Res 1994;55:1434-1443.
47. Recknagel RO, Glende EA Spectrophotometric detection of lipid conjugated dienes. Methods Enzymol 1984;105:331-337.
48. Chiu CJ, McArdle AH, Brown R, et al. Intestinal mucosal lesions in low states. 1. A morphologic, hemodynamic and metabolic reappraisal. Arch Surg 1970;101:478-483.
49. Sullivan KE, Snyder JR, Schiedt MJ, et al. Lipid peroxidation and antioxidative defences during ischemia and reperfusion of the equine ascending colon. Equine Vet J Suppl 1992;13.99-101.
50. Arden WA, Stick JA, Parks AH, et al. Effects of ischemia and dimethyl sulfoxide on equine jejunal vascular resistance, oxygen consumption, intraluminal pressure, and potassium loss. Am J Vet Res 1989;50 380-387.
51. Michel CC. Capillary permeability and how it may change. J Physiol 1988;404:1-29
52. Granger DN, Sennett M, McElearney P, et al Effect of local arterial hypotension on cat intestinal capillary permeability. Gastroenterology 1980,79:474-480.
53. Williams TJ, Yarwood H. Effect of glucocorticoid on microvascular permeability. Am Rev Respir Dis 1990,141:S39-S43.
54. Dabareiner RM, White NA, Lemasters JJ. Effect of a reperfusion solution, "Carolina rinse," on intestinal vascular permeability and blood flow after jejunal ischemia and reperfusion in the horse. Vet Surg 1994;23:399.
55. Dabareiner RM, Sullins KE, Snyder JR, et al. Evaluation of the microcirculation of the equine small intestine after intraluminal distension and subsequent decompression. Am J Vet Res 1993;54: 1673-1682.
56. Moore RM, Muir WW, Bertone AL, et al. Effects of dimethyl sulfoxide, allopurinol, 21-aminosteroid U-74389G, and manganese chloride on Low-flow ischemia and reperfusion of the large colon in horses. Am J Vet Res 1995;56:671-687.
57. Granger DN, Grisham MB, Kvietys PR Mechanisms of microvascular injury In. Johnson LR, ed Physiology of the gastrointestinal tract. New York: Raven Press, 1994;1693-1722.