How shunting inhibition affects the discharge of lumbar motoneurones: A dynamic clamp study in anaesthetized cats

Journal of Physiology

Volumn 558, Issue 2, 2004, Pages 671-683

  Brizzi, L ^a   Meunier, C ^a   Zytnicki, Daniel ^a   Donnet, M ^a   Hansel, D ^a   Lamotte d'Incamps, B ^a   van Vreeswijk, C ^a  

^a CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTION POTENTIAL; ANIMAL TISSUE; ARTICLE; CALIBRATION; CAT; CONTROLLED STUDY; HYPERPOLARIZATION; LUMBAR SPINE; MICROELECTRODE; NERVE CELL INHIBITION; NERVE CELL MEMBRANE CONDUCTANCE; NERVE CELL MEMBRANE POTENTIAL; NERVE CELL MEMBRANE STEADY POTENTIAL; NERVE CELL STIMULATION; NONHUMAN; PERIKARYON; PLOTS AND CURVES; PRIORITY JOURNAL; SHUNTING; SPIKE WAVE; SPINAL CORD MOTONEURON; SYNAPTIC TRANSMISSION; THEORETICAL MODEL; VOLTAGE CLAMP; ADULT; ANIMAL EXPERIMENT; FIRING RATE; FREQUENCY MODULATION; MOTONEURON; NERVE CELL EXCITABILITY; NERVE POTENTIAL; NERVOUS SYSTEM FUNCTION; REPETITIVE DISCHARGE; SHUNTING INHIBITION; SYNAPTIC POTENTIAL;

ACTION POTENTIALS; ANESTHESIA; ANIMALS; CATS; LUMBAR VERTEBRAE; MOTOR NEURONS; NEURAL INHIBITION; PATCH-CLAMP TECHNIQUES; SPINAL CORD;

EID: 4344664669     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2003.059964     Document Type: Article

References (43)

1. Baldissera F, Gustafsson B & Parmiggiani F (1976). A model for refractoriness accumulation and secondary range firing in spinal motoneurones. Biol Cyber 24, 61-65.
2. Bennett DJ, Hultborn H, Fedirchuk B & Gorassini M (1998). Synaptic activation of plateaus in hindlimb motoneurones of decerebrate cats. J Neurophysiol 80, 2023-2037.
3. Brizzi L, Hansel D, Meunier D, Van Vreeswijk C & Zytnicki D (2001). Shunting inhibition: a study using in vivo dynamic clamp on cat spinal motoneurons. Soc Neurosci Abstr 27, 934.3.
4. Brownstone RM, Jordan LM, Kriellaars DJ, Noga BR & Schefchyk SJ (1992). On the regulation of repetitive firing in lumbar motoneurones during fictive locomotion in the cat. Exp Brain Res 90, 441-455.
5. Burke RE, Fedina L & Lundberg A (1971). Spatial synaptic distribution of recurrent and group Ia inhibitory systems in cat spinal motoneurones. J Physiol 214, 305-326.
6. Capaday C (2002). A re-examination of the possibility of controlling the firing gain of neurons by balancing excitatory and inhibitory conductances. Exp Brain Res 143, 67-77.
7. Chance FS, Abbott LF & Reyes AD (2002). Gain modulation from background synaptic input. Neuron 35, 773-782.
8. Coombs JS, Eccles JC & Fatt P (1955a). The specific ionic conductances and the ionic movements across the motoneuronal membrane that produce the inhibitory post-synaptic potential. J Physiol 130, 326-373.
9. Coombs JS, Eccles JC & Fatt P (1955b). The inhibitory suppression of reflex discharges from motoneurones. J Physiol 130, 396-413.
10. Cymbalyuk GS, Gaudry Q, Masino MA & Calabrese RL (2002). Bursting in leech heart interneurons: cell-autonomous and network-based mechanisms. J Neurosci 22, 10580-10592.
11. Fyffe RE (1991 ). Spatial distribution of recurrent inhibitory synapses on spinal motoneurons in the cat. J Neurophysiol 65, 1134-1149.
12. Gosnach S, Quevedo J, Fedirbuck B & McCrea DA (2000). Depression of group Ia monosynaptic EPSPs in cat hindlimb motoneurones during fictive locomotion. J Physiol 526, 639-652.
13. Granit R, Kernell D & Lamarre Y (1966a). Algebrical summation in synaptic activation of motoneurones firing within the primary range to injected currents. J Physiol 187, 379-399.
14. Granit R, Kernell D & Lamarre Y (1966b). Synaptic stimulation superimposed on motoneurones firing in the 'secondary range' to injected current. J Physiol 187, 401-415.
15. Graybill FA ( 1961). An Introduction to Linear Statistical Models. McGraw-Hill, New York.
16. Gustafsson B & Pinter J (1984). Relations among passive electrical properties of lumbar α-motoneurones of the cat. J Physiol 356, 401-434.
17. Hansel D, Mato G & Meunier C (1993). Phase reduction and neural modeling. Concepts Neurosci 4, 193-210.
18. Holt GR & Koch C (1997). Shunting inhibition does not have a divisive effect on firing rates. Neural Comput 9, 1001-1013.
19. Hounsgaard J, Hultborn H, Jespersen B & Kiehn O (1988). Bistability of alpha-motoneurones in the decerebrate cat and in the acute spinal cat after intravenous 5-hydroxytryptophan. J Physiol 414, 345-367.
20. Hultborn H, Enriquez-Denton M, Wienecke J & Nielsen JB (2003). Variable amplification of synaptic input to cat spinal motoneurones by dendritic persistent inward current. J Physiol 552, 945-952.
21. Kernell D (1966). The repetitive discharge of motoneurones. In Muscular Afferents and Motor Control, ed. Granit R, pp. 351-362. John Wiley & Sons, New-York, London, Sydney; Almqvist & Wiksell, Stockholm.
22. Kernell D (1968). The repetitive impulse discharge of a simple neurone model compared to that of spinal motoneurones. Brain Res 11, 685-687.
23. Kuo JJ, Lee RH, Johnson MD, Heckman HM & Heckman CJ (2003). Active dendritic integration of inhibitory synaptic inputs in vivo. J Neurophysiol 90, 3617-3624.
24. Le Masson G, Renaud-Le Masson S, Debay D & Bal T (2002). Feedback inhibition controls spike transfer in hybrid thalamic circuits. Nature 417, 854-858.
25. Manor Y, Yarom Y, Chorev E & Devor A (2000). To beat or not to beat: a decision taken at the network level. J Physiol (Paris) 94, 375-390.
26. Mitchell SJ & Silver AR (2003). Shunting inhibition modulates neuronal gain during synaptic excitation. Neuron 38, 433-445.
27. Nelson PG & Frank K (1967). Anomalous rectification in cat spinal motoneurons and effect of polarizing currents on excitatory post-synaptic potentials. J Neurophysiol 30, 1097-1113.
28. Perreault M-C (2002). Motoneurons have different membrane resistance during fictive scratching and weight support. J Neurosci 22, 8259-8265.
29. Poliakov AV, Powers RK & Binder MD (1997). Functional identification of the input-output transforms of motoneurones in the rat and cat. J Physiol 504, 401-424.
30. Powers RK & Binder MD (1995). Effective synaptic current and motoneuron firing rate modulation. J Neurophysiol 74, 793-801.
31. Powers RK & Binder MD (2001). Input-output functions of mammalian motoneurons. Rev Physiol Biochem Pharmacol 143, 137-263.
32. Prinz AA, Abbott LF & Marder E (2004). The dynamic clamp comes of age. Trends Neurosci 27, 218-224.
33. Robinson HP & Kawai N (1993). Injection of digitally synthesized synaptic conductance transients to measure the integrative properties of neurons. J Neurosci Meth 49, 157-165.
34. Schwindt PC (1973). Membrane-potential trajectories underlying motoneuron rhythmic firing at high rates. J Neurophysiol 36, 434-449.
35. Schwindt PC & Calvin WH (1973a). Equivalence of synaptic and injected current in determining the membrane potential trajectory during motoneuron rhythmic firing. Brain Res 59, 389-394.
36. Schwindt PC & Calvin WH (1973b). Nature of conductances underlying rhythmic firing cat spinal motoneurons. J Neurophysiol 36, 955-973.
37. Schwindt PC & Crill WE (1982). Factors influencing motoneuron rythmic firing: results from a voltage-clamp study. J Neurophysiol 48, 875-890.
38. Shapovalov AI & Grantyn AA (1968). Suprasegmental synaptic effect on chromatolyzed motor neurons. Biofizika 13, 260-269.
39. Sharp AA, O'Neil MB, Abbott LF & Marder E (1993). Dynamic clamp: computer-generated conductances in real neurons. J Neurophysiol 69, 992-995.
40. Shefchyk SJ & Jordan LM (1985). Motoneuron input-resistance changes during fictive locomotion produced by stimulation of the mesencephalic locomotor region. J Neurophysiol 54, 1101-1108.
41. Shriki O, Hansel D & Sompolinsky H (2003). Rate models for conductance-based cortical neuronal networks. Neural Comput 15, 1809-1841.
42. Ulrich D (2003). Differential arithmetic of shunting inhibition for voltage and spike rate in neocortical pyramidal cells. Eur J Neurosci 18, 2159-2165.
43. Zhang L & Krnjevic K (1987). Apamin depresses selectively the after-hyperpolarization of cat spinal motoneurons. Neurosci Lett 74, 58-62.