Clinical pharmacokinetic data of racemic drugs obtained by the indirect method following precolumn diastereomer formation: Is the influence of racemization during chiral derivatization significant?

Biomedical Chromatography

Volumn 18, Issue 6, 2004, Pages 343-349

  Srinivas, Nuggehally R ^a  

^a DR REDDY'S LABORATORIES LTD   (India)

Author keywords

Direct vs indirect chiral method; Drug discovery and development; Stereoselective analysis

Indexed keywords

CLINICAL PHARMACOKINETICS; DERIVATIZATIONS; DIASTEREOMERS; DIRECT VS INDIRECT CHIRAL METHOD; DRUG DEVELOPMENT; DRUG DISCOVERY; INDIRECT METHODS; PHARMACOKINETIC DATA; STEREO-SELECTIVE; STEREOSELECTIVE ANALYSIS;

STEREOSELECTIVITY;

AMPHETAMINE; ATENOLOL; BETAXOLOL; BEVANTOLOL; BISOPROLOL; CYCLOPHOSPHAMIDE; FENFLURAMINE; FENOPROFEN; FLUOXETINE; FLURBIPROFEN; IBUPROFEN; KETOPROFEN; MEFLOQUINE; METHOXYPHENAMINE; METHYLPHENIDATE; METOPROLOL; MEXILETINE; NORFENFLURAMINE; NORVERAPAMIL; PINDOLOL; PROPAFENONE; PROPRANOLOL; RITALINIC ACID; SOTALOL; TIAPROFENIC ACID; TOCAINIDE; TRANYLCYPROMINE; VENLAFAXINE; VERAPAMIL;

AREA UNDER THE CURVE; CHIRALITY; DATA ANALYSIS; DERIVATIZATION; DIASTEREOISOMER; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; HUMAN; MEDICAL PRACTICE; METHODOLOGY; NONHUMAN; RACEMIC MIXTURE; REVIEW; STEREOCHEMISTRY;

EID: 4344657868     PISSN: 02693879     EISSN: None     Source Type: Journal    
DOI: 10.1002/bmc.376     Document Type: Review

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