Presence of cytochrome P450 enzymes in human CD34+ haematopoietic progenitor cells

General Physiology and Biophysics

Volumn 23, Issue 2, 2004, Pages 251-257

  Kousalova L ^a   Anzenbacherova E ^a   Baranova J ^a   Anzenbacher, Pavel ^a   Skoumalova I ^b   Vondrakova J ^b  

^a PALACKÝ UNIVERSITY   (Czech Republic)

^b UNIVERSITY HOSPITAL OLOMOUC   (Czech Republic)

Author keywords

CYP2E1; CYP3A4; Cytochromes P450; Haematopoietic stem cells; Progenitor cells

Indexed keywords

CHLORZOXAZONE; CYTOCHROME P450; CYTOCHROME P450 2E1; CYTOCHROME P450 3A; CYTOCHROME P450 3A2; CYTOCHROME P450 3A4; NIFEDIPINE;

ARTICLE; BONE MARROW; CELL POPULATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME LOCALIZATION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MALE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANTIGENS, CD34; ARYL HYDROCARBON HYDROXYLASES; CELLS, CULTURED; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 ENZYME SYSTEM; HEMATOPOIETIC STEM CELLS; HUMANS;

STAPHYLOCOCCUS PHAGE 3A;

EID: 4344649039     PISSN: 02315882     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Alison M. R., Poulsom R., Jeffery R., Dhillon A. P., Quaglia A., Jacob J., Novelli M., Prentice G., Williamson J., Wright N. A. (2000): Hepatocytes from non-hepatic adult stem cells. Nature 406, 257
2. Anzenbacher P., Anzenbacherová E. (2001): Cytochromes P450 and metabolism of xenobiotics. Cell. Mol. Life Sci. 58, 737-747
3. Avital I., Inderbitzin D., Aoki T., Tyan D. B., Cohen A. H., Ferraresso C., Rozga J., Arnaout W. S., Demetriou A. A. (2001): Isolation, characterization, and transplantation of bone marrow-derived hepatocyte stem cells. Biochem. Biophys. Res. Commun. 288, 156-164
4. Bernauer U., Vieth B., Ellrich R., Heinrich-Hirsch B., Jänig G.-R., Gundert-Remy, U. (2000): CYP2E1 expression in bone marrow and its intra-and interspecies variability: approaches for a more reliable extrapolation from one species to another in the risk assessment of chemicals. Arch. Toxicol. 73, 618-624
5. Carriere V., Goasduff T., Ratanasavanh D., Morel F., Gautier J. C., Guillouzo A., Beaune P., Berthou F. (1993): Both cytochromes P450 2E1 and 1A1 are involved in metabolism of chlorzoxazone. Chem. Res. Toxicol. 6, 852-857
6. Crespi C. L., Chang T. K. H., Waxman D. J. (1998): Determination of CYP2C9-catalyzed diclofenac 4′-hydroxylation by HPLC. In: Cytochrome P450 Protocols (Eds. I. R. Phillips and E. A. Shephard), pp. 129-133, Humana Press, Totowa, NJ
7. Gorski J. C., Jones D. R., Wrighton S. A., Hall S. D. (1997): Contribution of human CYP3A subfamily members to the 6′ -hydroxylation of chlorzoxazone. Xenobiotica 27, 243-256
8. Guengerich F. P., Martin M. V., Beaune P. H., Kremers P., Wolff T., Waxman D. J. (1986): Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in in oxidative drug metabolism. J. Biol. Chem. 261, 5051-5060
9. Lagasse E., Connors H., Al-Dhalimy M., Reitsma. M., Dohse M., Osborne L., Wang X., Finegold M., Weissman I. L., Grompe M. (2000): Purified haematopoietic stem cells can differentiate into hepatocytes in vivo. Nat. Med. 6, 1229-1234
10. Lieber C. S. (1997): Cytochrome P-450 2E1: its physiological and pathological role. Physiol. Rev. 77, 517-544
11. Lucas D., Berthou F., Girre C., Poitrenaud F., Ménez J.-F. (1993): High-performance liquid chromatographic determination of.chlorzoxazone and 6-hydroxychlorzoxazone in serum: a tool for indirect evaluation of cytochrome P4502E1 activity in humans. J. Chromatogr. 622, 79-86
12. Nissbrandt H., Bergquist F., Jonason J., Engberg G. (2001): Inhibition of cytochrome P450 2E1 induces an increase in extracellular dopamine in rat substantia nigra: a new metabolic pathway? Synapse 40, 294-301
13. Ortiz de Montellano P. R. (1995): Cytochrome P450. Structure, Mechanism and Biochemistry. Plenum Press, New York
14. Schwartz R. E., Reyes M., Koodie L., Jiang Y., Blackstad M., Lund T., Lenvik T., Johnson S., Hu W., Verfaillie C. M. (2002): Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. J. Clin. Invest. 109, 1291-1302
15. Souček P., Martin M. V., Ueng Y. F., Guengerich F. P. (1995): Identification of a common cytochrome P450 epitope near the conserved heme-binding petide with antibodies raised against recombinant cytochrome P450 family 2 proteins. Biochemistry 34, 16013-16021
16. Yamazaki H., Guo Z., Guengerich F. P. (1995): Selectivity of cytochrome P4502E1 in chlorzoxazone 6-hydroxylation. Drug Metab. Dispos. 23, 438-440